{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,22]],"date-time":"2026-06-22T10:49:55Z","timestamp":1782125395589,"version":"3.54.5"},"reference-count":17,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2025,11,19]],"date-time":"2025-11-19T00:00:00Z","timestamp":1763510400000},"content-version":"vor","delay-in-days":18,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2025,11,1]],"date-time":"2025-11-01T00:00:00Z","timestamp":1761955200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Int J of Rheum Dis"],"published-print":{"date-parts":[[2025,11]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Objectives<\/jats:title>\n                    <jats:p>Patients with refractory lupus nephritis (LN) may benefit from the addition of anti\u2010lupus drugs to standard remission induction therapy; however, which patients require additional treatment remains unclear. This study aimed to identify the predictive factors for renal outcomes during standard remission induction treatment for LN.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      This retrospective observational study included 85 LN patients with standard remission induction therapy between 2006 and 2020. The baseline was the day of the initiation of remission induction therapy. Clinical and laboratory data were collected at 0, 2, 4, 8, 12 and 52\u2009weeks after baseline. Complete renal remission (CRR) was defined as proteinuria &lt;\u20090.5\u2009g\/gCr plus estimated glomerular filtration rate no worse than 10% below preflare value or\u2009\u2265\u200990\u2009mL\/min\/1.73\u2009m\n                      <jats:sup>2<\/jats:sup>\n                      at 52\u2009weeks.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Among 85 patients, 48 (56.5%) achieved CRR at 52\u2009weeks. Baseline serum creatinine (Cr) and proteinuria levels were not significantly different between the CRR and non\u2010CRR groups. In the CRR group, the rate of decrease (%) in serum Cr at each period from baseline was significantly higher, while proteinuria at 12\u2009weeks was significantly lower. Multivariate logistic regression identified the rate of decrease in serum Cr from baseline to 12\u2009weeks (odds ratio\u2009=\u20091.25 [CI 1.03\u20131.55],\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.03) and proteinuria at 12\u2009weeks (odds ratio\u2009=\u20090.71 [CI 0.49\u20130.95],\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.05) as independent predictive factors for CRR. Receiver operating characteristic curve analysis suggested proteinuria \u2264\u20090.8\u2009g\/gCr at 12\u2009weeks as the best cutoff to predict CRR.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>The serum Cr decrease and proteinuria \u2264\u20090.8\u2009g\/gCr at 12\u2009weeks were predictors of CRR.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/1756-185x.70470","type":"journal-article","created":{"date-parts":[[2025,11,20]],"date-time":"2025-11-20T06:24:41Z","timestamp":1763619881000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Predictive Factors for Renal Outcome During Remission Induction Treatment Period in Lupus Nephritis"],"prefix":"10.1111","volume":"28","author":[{"given":"Kazuro","family":"Kamada","sequence":"first","affiliation":[{"name":"Department of Rheumatology, Endocrinology and Nephrology, Faculty of Medicine and Graduate School of Medicine Hokkaido University  Sapporo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7663-534X","authenticated-orcid":false,"given":"Michihito","family":"Kono","sequence":"additional","affiliation":[{"name":"Department of Rheumatology, Endocrinology and Nephrology, Faculty of Medicine and Graduate School of Medicine Hokkaido University  Sapporo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shuhei","family":"Takeyama","sequence":"additional","affiliation":[{"name":"Department of Rheumatology, Endocrinology and Nephrology, Faculty of Medicine and Graduate School of Medicine Hokkaido University  Sapporo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ryo","family":"Hisada","sequence":"additional","affiliation":[{"name":"Department of Rheumatology, Endocrinology and Nephrology, Faculty of Medicine and Graduate School of Medicine Hokkaido University  Sapporo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuichiro","family":"Fujieda","sequence":"additional","affiliation":[{"name":"Department of Rheumatology, Endocrinology and Nephrology, Faculty of Medicine and Graduate School of Medicine Hokkaido University  Sapporo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2023-6585","authenticated-orcid":false,"given":"Masaru","family":"Kato","sequence":"additional","affiliation":[{"name":"Department of Rheumatology, Endocrinology and Nephrology, Faculty of Medicine and Graduate School of Medicine Hokkaido University  Sapporo Japan"},{"name":"The First Department of Internal Medicine University of Toyama Faculty of Medicine  Toyama Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Olga","family":"Amengual","sequence":"additional","affiliation":[{"name":"Department of Rheumatology, Endocrinology and Nephrology, Faculty of Medicine and Graduate School of Medicine Hokkaido University  Sapporo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tatsuya","family":"Atsumi","sequence":"additional","affiliation":[{"name":"Department of Rheumatology, Endocrinology and Nephrology, Faculty of Medicine and Graduate School of Medicine Hokkaido University  Sapporo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2025,11,19]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41590\u2010020\u20100677\u20106"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.ajkd.2019.10.017"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41572\u2010019\u20100141\u20109"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.2215\/cjn.03230319"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.1093\/rheumatology\/keaa381"},{"key":"e_1_2_10_7_1","doi-asserted-by":"publisher","DOI":"10.1177\/0961203314536246"},{"key":"e_1_2_10_8_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa2001180"},{"key":"e_1_2_10_9_1","doi-asserted-by":"publisher","DOI":"10.7326\/m14\u20101030"},{"key":"e_1_2_10_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/s0140\u20106736(21)00578\u2010x"},{"key":"e_1_2_10_11_1","doi-asserted-by":"publisher","DOI":"10.1136\/ard\u20102023\u2010224762"},{"key":"e_1_2_10_12_1","doi-asserted-by":"publisher","DOI":"10.1093\/mr\/roac007"},{"key":"e_1_2_10_13_1","doi-asserted-by":"publisher","DOI":"10.1136\/lupus\u20102020\u2010000389"},{"key":"e_1_2_10_14_1","doi-asserted-by":"publisher","DOI":"10.1002\/art.39026"},{"key":"e_1_2_10_15_1","doi-asserted-by":"publisher","DOI":"10.1136\/lupus\u20102015\u2010000123"},{"key":"e_1_2_10_16_1","doi-asserted-by":"publisher","DOI":"10.1136\/annrheumdis\u20102020\u2010216924"},{"key":"e_1_2_10_17_1","doi-asserted-by":"publisher","DOI":"10.1093\/rheumatology\/keab126"},{"key":"e_1_2_10_18_1","doi-asserted-by":"publisher","DOI":"10.1002\/acr.20397"}],"container-title":["International 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