{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,15]],"date-time":"2026-02-15T06:07:50Z","timestamp":1771135670086,"version":"3.50.1"},"reference-count":44,"publisher":"Wiley","issue":"12","license":[{"start":{"date-parts":[[2025,11,28]],"date-time":"2025-11-28T00:00:00Z","timestamp":1764288000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2025,11,28]],"date-time":"2025-11-28T00:00:00Z","timestamp":1764288000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Int J of Rheum Dis"],"published-print":{"date-parts":[[2025,12]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>In systemic lupus erythematosus (SLE), thrombocytopenia is a common hematological complication associated with severe disease manifestations and increased mortality.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objectives<\/jats:title>\n                    <jats:p>The study aimed to investigate the prevalence of thrombocytopenia in the Oman lupus cohort and explore its correlation with clinical, immunological, and epidemiological characteristics, as well as mortality and survival outcomes.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>The study forms a section of the Oman Lupus Study, which is a longitudinal research initiative that includes 1 160 patients diagnosed with SLE between January 2006 and February 2020. The patients were evaluated for the prevalence of thrombocytopenia, which was further analyzed in relation to epidemiological and clinical characteristics, laboratory profile, survival, and mortality outcomes.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Thrombocytopenia was found in 22.5% of patients (262\/1 160), with no significant difference between males (12%) and females (88%,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.642). There were significant correlations between thrombocytopenia and antiphospholipid antibodies, as well as organ involvement, such as renal (5.3% vs. 0.6%,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.000), neuropsychiatric (30.9% vs. 17.9%,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.000), and respiratory complications (25.6% vs. 16.4%,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.001). A similar prevalence rate was identified between pediatric and adult patients (20.2% vs. 22.8%,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.490). It has been demonstrated that the mortality rate in thrombocytopenia patients was significantly higher (11.1% vs. 2.9%,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.000), translating to a nearly fourfold increased risk. The Kaplan\u2013Meier curve indicated that patients with thrombocytopenia had a reduced survival rate.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Thrombocytopenia impacts nearly a quarter of lupus patients and is strongly associated with organ involvement and increased mortality risk, irrespective of gender or age. These findings underscore the necessity for additional research and specialized guidelines to enhance outcomes in this high\u2010risk group.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/1756-185x.70490","type":"journal-article","created":{"date-parts":[[2025,11,29]],"date-time":"2025-11-29T02:04:31Z","timestamp":1764381871000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Comprehensive Analysis of Thrombocytopenia in Systemic Lupus Erythematosus: Prevalence, Immunological Correlations, and Mortality Outcomes in the Oman Lupus Cohort"],"prefix":"10.1111","volume":"28","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7448-9019","authenticated-orcid":false,"given":"Nasra K.","family":"Al\u2010Adhoubi","sequence":"first","affiliation":[{"name":"Rheumatology Unit Royal Hospital  Muscat Oman"},{"name":"Internal Medicine, Oman Medical Specialty Board  Muscat Oman"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Juma","family":"Al Kaabi","sequence":"additional","affiliation":[{"name":"Rheumatology Unit Al Buraimi Hospital  Al Buraimi Oman"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Issa","family":"Al Salmi","sequence":"additional","affiliation":[{"name":"Internal Medicine, Oman Medical Specialty Board  Muscat Oman"},{"name":"Nephrology Department Royal Hospital  Muscat Oman"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1189-1959","authenticated-orcid":false,"given":"Reem","family":"Abdwani","sequence":"additional","affiliation":[{"name":"Pediatric Rheumatology Unit Sultan Qaboos University  Muscat Oman"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Farida","family":"Al\u2010Balushi","sequence":"additional","affiliation":[{"name":"Rheumatology Unit Royal Hospital  Muscat Oman"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Maha","family":"Ali","sequence":"additional","affiliation":[{"name":"Rheumatology Unit Al Nahdha Hospital  Muscat Oman"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Talal","family":"Al Lawati","sequence":"additional","affiliation":[{"name":"Adult Rheumatology Unit Sultan Qaboos University Hospital  Muscat Oman"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"B. 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H.","family":"Al Lawati","sequence":"additional","affiliation":[{"name":"Adult Rheumatology Unit Sultan Qaboos University Hospital  Muscat Oman"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ali","family":"Al Shamsi","sequence":"additional","affiliation":[{"name":"Rheumatology Unit Al Buraimi Hospital  Al Buraimi Oman"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Musallam","family":"Al Mashaani","sequence":"additional","affiliation":[{"name":"Rheumatology Unit Sultan Qaboos Hospital  Dhofar Oman"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Divij Krishna","family":"Jha","sequence":"additional","affiliation":[{"name":"Rheumatology Unit Royal Hospital  Muscat Oman"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sherin","family":"Sayed","sequence":"additional","affiliation":[{"name":"Rheumatology Unit Royal Hospital  Muscat Oman"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tariq","family":"Al\u2010Araimi","sequence":"additional","affiliation":[{"name":"Rheumatology Unit Royal Hospital  Muscat Oman"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Prabha","family":"Liyanage","sequence":"additional","affiliation":[{"name":"Rheumatology Unit Royal Hospital  Muscat Oman"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hilal","family":"Al Kalbani","sequence":"additional","affiliation":[{"name":"Internal Medicine, Ibri Hospital  Muscat Oman"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0005-7980-9877","authenticated-orcid":false,"given":"Humaid A.","family":"Al Wahshi","sequence":"additional","affiliation":[{"name":"Rheumatology Unit Royal Hospital  Muscat Oman"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2025,11,28]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.autrev.2023.103297"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaut.2022.102887"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.1136\/annrheumdis\u20102018\u2010214819"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.autrev.2024.103721"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.1155\/2024\/6650921"},{"key":"e_1_2_10_7_1","doi-asserted-by":"publisher","DOI":"10.31138\/mjr.28.1.20"},{"key":"e_1_2_10_8_1","doi-asserted-by":"publisher","DOI":"10.1182\/bloodadvances.2019000966"},{"key":"e_1_2_10_9_1","doi-asserted-by":"publisher","DOI":"10.1136\/ard\u20102023\u2010224762"},{"key":"e_1_2_10_10_1","doi-asserted-by":"publisher","DOI":"10.1136\/annrheumdis\u20102017\u2010211631"},{"key":"e_1_2_10_11_1","doi-asserted-by":"publisher","DOI":"10.1002\/art.40439"},{"key":"e_1_2_10_12_1","doi-asserted-by":"publisher","DOI":"10.1093\/mrcr\/rxad055"},{"key":"e_1_2_10_13_1","doi-asserted-by":"publisher","DOI":"10.1177\/09612033241241576"},{"key":"e_1_2_10_14_1","doi-asserted-by":"publisher","DOI":"10.1093\/rheumatology\/kead171"},{"key":"e_1_2_10_15_1","doi-asserted-by":"publisher","DOI":"10.3324\/haematol.2020.259481"},{"issue":"6","key":"e_1_2_10_16_1","article-title":"The Safety and Efficacy of Rituximab and Belimumab in Systemic Lupus Erythematosus: A Systematic Review","volume":"15","author":"Abid N.","year":"2023","journal-title":"Cureus"},{"key":"e_1_2_10_17_1","doi-asserted-by":"publisher","DOI":"10.3324\/haematol.2019.218883"},{"key":"e_1_2_10_18_1","doi-asserted-by":"publisher","DOI":"10.1111\/bjh.16672"},{"key":"e_1_2_10_19_1","doi-asserted-by":"publisher","DOI":"10.1177\/0961203312463621"},{"key":"e_1_2_10_20_1","doi-asserted-by":"publisher","DOI":"10.1080\/14740338.2024.2416540"},{"key":"e_1_2_10_21_1","doi-asserted-by":"publisher","DOI":"10.1111\/1756\u2010185X.14130"},{"key":"e_1_2_10_22_1","doi-asserted-by":"publisher","DOI":"10.1080\/09537104.2021.1988547"},{"key":"e_1_2_10_23_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2249.2006.03122.x"},{"issue":"3","key":"e_1_2_10_24_1","article-title":"A Practical Perspective of the Hematologic Manifestations of Systemic Lupus Erythematosus","volume":"14","author":"Santacruz J. 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