{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,15]],"date-time":"2026-02-15T06:07:54Z","timestamp":1771135674014,"version":"3.50.1"},"reference-count":26,"publisher":"Wiley","issue":"12","license":[{"start":{"date-parts":[[2025,12,17]],"date-time":"2025-12-17T00:00:00Z","timestamp":1765929600000},"content-version":"vor","delay-in-days":16,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2025,12,1]],"date-time":"2025-12-01T00:00:00Z","timestamp":1764547200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Int J of Rheum Dis"],"published-print":{"date-parts":[[2025,12]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>This study aims to assess the incidence and factors linked to venous thromboembolic events (VTE) in a large national cohort of antineutrophil cytoplasmic autoantibody (ANCA)\u2010associated vasculitis (AAV) from the Turkish Vasculitis Study Group (TR\u2010VaS).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Method<\/jats:title>\n                    <jats:p>This retrospective analysis included patients with granulomatosis with polyangiitis, microscopic polyangiitis, renal\u2010limited vasculitis, and eosinophilic granulomatosis with polyangiitis. VTE that occurred within 3\u2009months before the diagnosis of AAV or during the follow\u2010up period was classified as AAV\u2010associated VTE (AAV\u2010VTE). Demographic, clinical, and disease\u2010related features, along with the presence of well\u2010known VTE risk factors, were compared between AAV patients with and without VTE. Multivariate analyses were performed to identify independent risk factors linked to the development of AAV\u2010VTE.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      A total of 559 patients were included, and VTE was detected in 43 (7.7%). In univariate analysis, baseline body mass index (BMI) (HR: 1.13, 95% CI: 1.02\u20131.25,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.01), erythrocyte sedimentation rate (HR: 1.01, 95% CI: 1.00\u20131.02,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.04), BVAS score (HR: 1.05, 95% CI: 1.01\u20131.09,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.01), renal involvement (HR: 2.01, CI: 0.96\u20134.20,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.06), the presence of immobilization (HR: 11.4, 95% CI: 5.64\u201323.37,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.001), and trauma (HR: 28.84, 95% CI: 3.5\u2013215.7,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.001) were identified as risk factors for VTE\u2010AAV. In multivariate analysis, baseline BMI (HR: 1.14, CI: 1.02\u20131.26,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.002) was the only independent risk factor for the development of VTE.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Our findings suggest that physicians caring for AAV patients should be cautious about the risk of VTE in patients with an elevated BMI and active disease, along with other recognized risk factors for VTE.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/1756-185x.70506","type":"journal-article","created":{"date-parts":[[2025,12,18]],"date-time":"2025-12-18T04:46:19Z","timestamp":1766033179000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Venous Thromboembolism May Be Increased in the Early Phases of\n                    <scp>ANCA<\/scp>\n                    \u2010Associated Vasculitis and Could Be Associated With a High Body Mass Index:\n                    <scp>TR<\/scp>\n                    \u2010\n                    <scp>VaS<\/scp>\n                    Experience"],"prefix":"10.1111","volume":"28","author":[{"ORCID":"https:\/\/orcid.org\/0009-0001-5169-0633","authenticated-orcid":false,"given":"Hasan","family":"Kocaayan","sequence":"first","affiliation":[{"name":"Division of Rheumatology, Department of Internal Medicine, Faculty of Medicine Izmir Katip Celebi University  Izmir Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5504-1094","authenticated-orcid":false,"given":"Elif Durak","family":"Ediboglu","sequence":"additional","affiliation":[{"name":"Division of Rheumatology, Department of Internal Medicine, Faculty of Medicine Izmir Katip Celebi University  Izmir Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tuba Demirci","family":"Y\u0131ld\u0131r\u0131m","sequence":"additional","affiliation":[{"name":"Division of Rheumatology and Immunology, Department of Internal Medicine, Faculty of Medicine Dokuz Eylul University  Izmir Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bahar Ozdemir","family":"Ulusoy","sequence":"additional","affiliation":[{"name":"Division of Rheumatology, Department of Internal Medicine Ankara Bilkent City Hospital, University of Health Sciences  Ankara Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4189-3717","authenticated-orcid":false,"given":"Tahir Saygin","family":"Ogut","sequence":"additional","affiliation":[{"name":"Division of Rheumatology, Department of Internal Medicine, Vasculitis Research Centre, Faculty of Medicine Akdeniz University  Antalya Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9072-5683","authenticated-orcid":false,"given":"Busra","family":"Firlatan","sequence":"additional","affiliation":[{"name":"Division of Rheumatology, Department of Internal Medicine, Vasculitis Research Centre, Faculty of Medicine Hacettepe University  Ankara Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Duygu Sevinc","family":"Ozgur","sequence":"additional","affiliation":[{"name":"Division of Rheumatology, Department of Internal Medicine Basaksehir Cam and Sakura City Hospital, University of Health Sciences  Istanbul Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0047-1019","authenticated-orcid":false,"given":"Senar","family":"San","sequence":"additional","affiliation":[{"name":"Division of Rheumatology, Department of Internal Medicine, Faculty of Medicine Kocaeli University  Kocaeli 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