{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T12:46:44Z","timestamp":1777639604890,"version":"3.51.4"},"reference-count":38,"publisher":"Wiley","issue":"12","license":[{"start":{"date-parts":[[2025,12,21]],"date-time":"2025-12-21T00:00:00Z","timestamp":1766275200000},"content-version":"vor","delay-in-days":20,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2025,12,1]],"date-time":"2025-12-01T00:00:00Z","timestamp":1764547200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Int J of Rheum Dis"],"published-print":{"date-parts":[[2025,12]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Objectives<\/jats:title>\n                    <jats:p>\n                      This study aimed to assess the risk factors for\n                      <jats:italic>Pneumocystis<\/jats:italic>\n                      pneumonia (PCP) in patients with rheumatoid arthritis (RA) and investigate the potential of salazosulfapyridine (SASP) as a prophylactic agent.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>The present study analyzed data from the Japanese Diagnosis Procedure Combination database, which provides comprehensive inpatient data (including diagnoses, procedures, and medications) covering a large portion of the population. We identified patients with RA who developed PCP among 14\u2009190 patients diagnosed with RA at admission with a treatment history. Patients with RA who were receiving therapeutic doses of drugs for PCP were defined as having PCP. A nested case\u2013control analysis was performed to compare patients with RA and PCP with age\u2010 and sex\u2010matched control patients with RA without PCP in a ratio of 1:20.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>The cohort comprised 132 patients with PCP and 2575 controls. The risk factors for PCP in RA were chronic obstructive pulmonary disease, methotrexate (MTX), biological\/targeted synthetic DMARDs (b\/tsDMARDs), and high\u2010dose glucocorticoids. SASP may have a protective effect against PCP, particularly in patients with RA treated with MTX and\/or b\/tsDMARDs.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>The large sample size of the present study suggests that SASP may be associated with a reduced PCP risk in RA patients.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/1756-185x.70516","type":"journal-article","created":{"date-parts":[[2025,12,22]],"date-time":"2025-12-22T06:07:38Z","timestamp":1766383658000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Risk of\n                    <i>Pneumocystis<\/i>\n                    Pneumonia in Patients With Rheumatoid Arthritis and the Role of Prophylactic Salazosulfapyridine"],"prefix":"10.1111","volume":"28","author":[{"given":"Ryo","family":"Sato","sequence":"first","affiliation":[{"name":"Department of Orthopedic Surgery and Rheumatology Nagoya University Graduate School of Medicine  Aichi Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6469-1312","authenticated-orcid":false,"given":"Kenya","family":"Terabe","sequence":"additional","affiliation":[{"name":"Department of Orthopedic Surgery and Rheumatology Nagoya University Graduate School of Medicine  Aichi Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Takahiro","family":"Imaizumi","sequence":"additional","affiliation":[{"name":"Department of Advanced Medicine Nagoya University Hospital  Aichi Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1794-576X","authenticated-orcid":false,"given":"Koji","family":"Sakamoto","sequence":"additional","affiliation":[{"name":"Department of Respiratory Medicine Nagoya University Graduate School of Medicine  Aichi Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kikue","family":"Sato","sequence":"additional","affiliation":[{"name":"Medical IT Center Nagoya University Hospital  Aichi Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0006-6499-2573","authenticated-orcid":false,"given":"Junya","family":"Hasegawa","sequence":"additional","affiliation":[{"name":"Department of Orthopedic Surgery and Rheumatology Nagoya University Graduate School of Medicine  Aichi Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Takaya","family":"Sugiura","sequence":"additional","affiliation":[{"name":"Department of Orthopedic Surgery and Rheumatology Nagoya University Graduate School of Medicine  Aichi Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yusuke","family":"Ono","sequence":"additional","affiliation":[{"name":"Department of Orthopedic Surgery and Rheumatology Nagoya University Graduate School of Medicine  Aichi Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4895-5028","authenticated-orcid":false,"given":"Mochihito","family":"Suzuki","sequence":"additional","affiliation":[{"name":"Department of Orthopedic Surgery and Rheumatology Nagoya University Graduate School of Medicine  Aichi Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shuji","family":"Asai","sequence":"additional","affiliation":[{"name":"Department of Orthopedic Surgery and Rheumatology Nagoya University Graduate School of Medicine  Aichi Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shiro","family":"Imagama","sequence":"additional","affiliation":[{"name":"Department of Orthopedic Surgery and Rheumatology Nagoya University Graduate School of Medicine  Aichi Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2025,12,21]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.3109\/14397595.2013.854059"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(16)30173-8"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1136\/annrheumdis-2019-216655"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1093\/rheumatology\/key207"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMra032588"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1093\/mr\/roac088"},{"issue":"1","key":"e_1_2_9_8_1","first-page":"29","article-title":"Pneumocystis jirovecii Pneumonia in Rheumatoid Arthritis Patients: Risks and Prophylaxis Recommendations","volume":"9","author":"Mori S.","year":"2015","journal-title":"Clinical Medicine Insights. 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