{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,8]],"date-time":"2026-03-08T23:10:47Z","timestamp":1773011447188,"version":"3.50.1"},"reference-count":50,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2026,2,11]],"date-time":"2026-02-11T00:00:00Z","timestamp":1770768000000},"content-version":"vor","delay-in-days":10,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,2,1]],"date-time":"2026-02-01T00:00:00Z","timestamp":1769904000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100001691","name":"Japan Society for the Promotion of Science","doi-asserted-by":"publisher","award":["JP22K16348"],"award-info":[{"award-number":["JP22K16348"]}],"id":[{"id":"10.13039\/501100001691","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Int J of Rheum Dis"],"published-print":{"date-parts":[[2026,2]]},"abstract":"ABSTRACT<\/jats:title>\n \n Background<\/jats:title>\n \n Bronchiectasis is known to be more frequently observed in patients with microscopic polyangiitis (\n MPA<\/jats:styled-content>\n ) and granulomatosis with polyangiitis (\n GPA<\/jats:styled-content>\n ) compared to the general population. However, its association with patient outcomes and the potential influence of immunosuppressive treatment on this association remain unclear.\n <\/jats:p>\n <\/jats:sec>\n \n Methods<\/jats:title>\n \n We conducted a multicenter observational study using data from the Japan Collaborative Registry of\n ANCA<\/jats:styled-content>\n \u2010Associated Vasculitis (J\u2010\n CANVAS<\/jats:styled-content>\n ). Adult patients with newly diagnosed or relapsing\n MPA<\/jats:styled-content>\n or\n GPA<\/jats:styled-content>\n between January 2017 and March 2023 were included. The exposure was clinically apparent bronchiectasis at baseline. Primary outcomes were serious infections and all\u2010cause mortality; relapses were examined as a secondary outcome over 52\u2009weeks. For each outcome, incidence rate ratios (\n IRRs<\/jats:styled-content>\n ) were estimated using multivariable Poisson regression models conditioned on confounding factors, incorporating follow\u2010up time as an offset term. Interactions between initial treatment (prednisone dose, rituximab, cyclophosphamide, intravenous methylprednisolone, and plasma exchange) and bronchiectasis were also evaluated.\n <\/jats:p>\n <\/jats:sec>\n \n Results<\/jats:title>\n \n Among 844 patients (\n MPA<\/jats:styled-content>\n : 614;\n GPA<\/jats:styled-content>\n : 230), 68 (8.1%) had bronchiectasis. During the follow\u2010up period, there were 122 serious infections among 101 patients, 48 deaths, and 85 relapses among 72 patients. Adjusted\n IRRs<\/jats:styled-content>\n for patients with bronchiectasis were 2.18 (95%\n CI<\/jats:styled-content>\n : 1.25\u20133.83) for serious infections, 3.07 (1.41\u20136.66) for mortality, and 1.58 (0.77\u20133.24) for relapse. No clear interaction was detected between specific treatments and bronchiectasis.\n <\/jats:p>\n <\/jats:sec>\n \n Conclusions<\/jats:title>\n \n Bronchiectasis was associated with increased risks of serious infections and mortality in patients with\n MPA<\/jats:styled-content>\n and\n GPA<\/jats:styled-content>\n . However, we did not detect clear interaction by initial treatment, suggesting that avoiding specific therapies may not be necessary.\n <\/jats:p>\n <\/jats:sec>","DOI":"10.1111\/1756-185x.70570","type":"journal-article","created":{"date-parts":[[2026,2,12]],"date-time":"2026-02-12T03:41:41Z","timestamp":1770867701000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Association Between Bronchiectasis and Serious Infections in Microscopic Polyangiitis and Granulomatosis With Polyangiitis From the J\u2010\n CANVAS<\/scp>"],"prefix":"10.1111","volume":"29","author":[{"given":"Satoshi","family":"Omura","sequence":"first","affiliation":[{"name":"Inflammation and Immunology, Graduate School of Medical Science Kyoto Prefectural University of Medicine Kyoto 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