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A total of 499 patients with SLE were recruited to explore the association between mtDNA CNVs and depression and anxiety. Meanwhile, the patients were followed up for 12\u2009weeks to observe the improvement of depression and anxiety. The levels of reactive oxygen species (ROS), adenosine triphosphate (ATP), interleukin\u20106 (IL\u20106), and interleukin\u20101\u03b2 (IL\u20101\u03b2) were detected.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Two mtDNA SNVs (C16291T, A16399G) in the displacement loop (D\u2010loop) region were associated with depression in patients with SLE (\n                      <jats:italic>P<\/jats:italic>\n                      <jats:sub>BH<\/jats:sub>\n                      \u2009=\u20090.003,\n                      <jats:italic>P<\/jats:italic>\n                      <jats:sub>BH<\/jats:sub>\n                      \u2009=\u20090.007). Two mtDNA SNVs (T9950C, T16140C) in the cytochrome c oxidase subunit III (COX3) gene and D\u2010loop region were associated with anxiety in patients with SLE (\n                      <jats:italic>P<\/jats:italic>\n                      <jats:sub>BH<\/jats:sub>\n                      \u2009=\u20090.001;\n                      <jats:italic>P<\/jats:italic>\n                      <jats:sub>BH<\/jats:sub>\n                      \u2009=\u20090.003). Associations of mtDNA CNVs with depression and anxiety in SLE were observed in several subgroups (\n                      <jats:italic>P<\/jats:italic>\n                      <jats:sub>adj<\/jats:sub>\n                      \u2009&lt;\u20090.05). T9950C and T16140C variants were related to the improvement of anxiety in SLE (\n                      <jats:italic>P<\/jats:italic>\n                      <jats:sub>BH<\/jats:sub>\n                      &lt;\u20090.05). An inverse U\u2010shaped non\u2010linear association was observed between mtDNA CNVs and the improvement of anxiety in the body mass index (BMI) \u2265\u200924 subgroup of SLE (\n                      <jats:italic>P<\/jats:italic>\n                      <jats:sub>non\u2010linear<\/jats:sub>\n                      \u2009=\u20090.038). The levels of ROS (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.040) and IL\u20106 (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.039) were increased and ATP level (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.034) was decreased in the COX3 gene variation group.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>mtDNA genetic variants may be associated with depression and anxiety in Chinese patients with SLE. This study provides a new idea for improving depression and anxiety in SLE.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/1756-185x.70595","type":"journal-article","created":{"date-parts":[[2026,3,8]],"date-time":"2026-03-08T15:13:52Z","timestamp":1772982832000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Association of Mitochondrial\n                    <scp>DNA<\/scp>\n                    Genetic Variants With Depression and Anxiety in Chinese Patients With Systemic Lupus Erythematosus"],"prefix":"10.1111","volume":"29","author":[{"given":"Qiqun","family":"Zong","sequence":"first","affiliation":[{"name":"Department of Epidemiology and Biostatistics, School of Public Health Anhui Medical University  Hefei Anhui China"},{"name":"Inflammation and Immune Mediated Diseases Laboratory of Anhui Province  Hefei Anhui 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