{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,27]],"date-time":"2026-08-27T04:02:08Z","timestamp":1787803328045,"version":"build-2784847793"},"reference-count":31,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2026,3,29]],"date-time":"2026-03-29T00:00:00Z","timestamp":1774742400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,3,29]],"date-time":"2026-03-29T00:00:00Z","timestamp":1774742400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Int J of Rheum Dis"],"published-print":{"date-parts":[[2026,4]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Aim<\/jats:title>\n                    <jats:p>Osteoarthritis (OA) is a common degenerative joint disease that is difficult to diagnose in its early stages, which can easily delay treatment. MicroRNAs (miRNAs) are key regulatory factors in the pathogenesis of OA. This study investigated the clinical diagnostic value of miR\u2010744\u20105p in OA and its regulatory effect on chondrocyte inflammation through modulation of thrombospondin\u20102 (THBS2).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>This study included 108 OA patients and 62 healthy controls. Serum levels of miR\u2010744\u20105p were detected using qRT\u2010PCR. The diagnostic value of miR\u2010744\u20105p was evaluated using the ROC curve and logistic regression. LPS\u2010induced chondrocyte OA models were used to assess the regulatory effect of miR\u2010744\u20105p on chondrocyte inflammation via CCK\u20108 and ELISA. Dual\u2010luciferase assay verified the targeting relationship between miR\u2010744\u20105p and THBS2.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      The serum level of miR\u2010744\u20105p in OA patients was markedly reduced (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.001), showing good diagnostic performance (AUC\u2009=\u20090.860). Logistic regression indicated that it could serve as an independent protective factor for OA (OR\u2009=\u20090.089). miR\u2010744\u20105p mimic significantly restored the viability of chondrocytes induced by LPS (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.001), inhibited the expression of inflammatory factors (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.001), and alleviated oxidative stress damage. Dual\u2010luciferase reporter assay confirmed that miR\u2010744\u20105p directly targets THBS2. Overexpression of THBS2 reversed the protective effects of miR\u2010744\u20105p.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>miR\u2010744\u20105p is significantly downregulated in OA and is a highly promising diagnostic and predictive molecule for OA. It can alleviate inflammation in chondrocytes by targeting THBS2, thereby inhibiting the progression of OA.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/1756-185x.70596","type":"journal-article","created":{"date-parts":[[2026,3,30]],"date-time":"2026-03-30T05:19:52Z","timestamp":1774847992000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["The Clinical Role of\n                    <scp>miR<\/scp>\n                    \u2010744\u20105p in Osteoarthritis and Its Regulation of Chondrocyte Inflammation Through the Modulation of Thrombospondin\u20102 (\n                    <scp>THBS2<\/scp>\n                    ) Expression"],"prefix":"10.1111","volume":"29","author":[{"given":"Baoping","family":"Du","sequence":"first","affiliation":[{"name":"Department of Orthopedic Surgery Linfen Central Hospital  Linfen Shanxi 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