{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,20]],"date-time":"2026-10-20T07:39:28Z","timestamp":1792481968548,"version":"4.5.0"},"reference-count":13,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2026,4,8]],"date-time":"2026-04-08T00:00:00Z","timestamp":1775606400000},"content-version":"vor","delay-in-days":7,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,4,1]],"date-time":"2026-04-01T00:00:00Z","timestamp":1775001600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82360325"],"award-info":[{"award-number":["82360325"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82371773"],"award-info":[{"award-number":["82371773"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["62363028"],"award-info":[{"award-number":["62363028"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Int J of Rheum Dis"],"published-print":{"date-parts":[[2026,4]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Objectives<\/jats:title>\n                    <jats:p>A single\u2010center, prospective, random, open\u2010label study of acute gout patients treated with etanercept.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>The treatment protocol involved subcutaneous administration of etanercept at a dose of 25\u2009mg twice in five days. The control group received 20\u2009mg of methylprednisolone administered intravenously every day for a total of five days. Baseline assessments, conducted at the initiation of etanercept included visual analogue scale (VAS) scores and C\u2010reactive protein (CRP) levels. The levels of CRP and VAS in the gout patient after being injected with etanercept or methylprednisolone for 5\u2009days. Adverse events were diligently recorded throughout the study period.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Etanercept demonstrated rapid and substantial alleviation of pain and inflammatory responses in all 12 acute gout patients. Its effect is comparable to that of methylprednisolone.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Etanercept might be contemplated for \u201coff\u2010label\u201d use in gout patients who do not respond to standard therapy or glucocorticoid therapy, encounter severe side\u2010effects and contraindications.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/1756-185x.70638","type":"journal-article","created":{"date-parts":[[2026,4,8]],"date-time":"2026-04-08T13:20:21Z","timestamp":1775654421000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Recombinant Human Tumor Necrosis Factor Receptor Fusion Protein as Treatment for Gout Flare"],"prefix":"10.1111","volume":"29","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8649-7916","authenticated-orcid":false,"given":"Jiao","family":"Luo","sequence":"first","affiliation":[{"name":"Department of Rheumatology and Clinical Immunology Jiangxi Provincial People's Hospital, the First Affiliated Hospital of Nanchang Medical College  Nanchang P.R. 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China"},{"name":"Jiangxi Province Key Laboratory of Immunity and Inflammation  China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"sijia","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Rheumatology and Clinical Immunology Jiangxi Provincial People's Hospital, the First Affiliated Hospital of Nanchang Medical College  Nanchang P.R. China"},{"name":"Jiangxi Province Key Laboratory of Immunity and Inflammation  China"},{"name":"Medical College of Nanchang University  Nanchang China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1631-4675","authenticated-orcid":false,"given":"Lihua","family":"Duan","sequence":"additional","affiliation":[{"name":"Department of Rheumatology and Clinical Immunology Jiangxi Provincial People's Hospital, the First Affiliated Hospital of Nanchang Medical College  Nanchang P.R. 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