{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,20]],"date-time":"2026-10-20T07:39:17Z","timestamp":1792481957629,"version":"4.5.0"},"reference-count":88,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2026,4,12]],"date-time":"2026-04-12T00:00:00Z","timestamp":1775952000000},"content-version":"vor","delay-in-days":11,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,4,1]],"date-time":"2026-04-01T00:00:00Z","timestamp":1775001600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100001745","name":"Asia Pacific League of Associations for Rheumatology","doi-asserted-by":"publisher","award":["APLAR SIG 2023"],"award-info":[{"award-number":["APLAR SIG 2023"]}],"id":[{"id":"10.13039\/501100001745","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Int J of Rheum Dis"],"published-print":{"date-parts":[[2026,4]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Introduction<\/jats:title>\n                    <jats:p>Juvenile idiopathic arthritis (JIA) is one of the most common chronic rheumatic diseases and requires coordinated and targeted treatment strategies to avoid long\u2010term disability. Existing guidelines from Western countries may not address region\u2010specific factors, including genetic heterogeneity, limited treatment availability, and limitations in healthcare infrastructure, in the Asia Pacific region. The aim of this systematic literature review (SLR) and meta\u2010analysis was to provide up\u2010to\u2010date evidence for the Asia Pacific League of Associations for Rheumatology (APLAR) recommendations for managing polyarticular course JIA (pcJIA) and temporomandibular joint (TMJ) arthritis.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>This systematic review followed PRISMA guidelines, with searches conducted on MEDLINE, Embase, Web of Science, Scopus, and CENTRAL through January 2025. Included studies addressed pharmacologic or non\u2010pharmacologic treatments for pcJIA and TMJ involvement. Studies were limited to publications not already covered in existing guidelines. The Cochrane Rob2 tool and GRADE approach were used to assess quality and evidence certainty. Meta\u2010analyses were performed where applicable.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Of the initial 9424 records, 86 studies were included in the qualitative analysis. Methotrexate remains the csDMARD of choice, and subcutaneous administration may be more advantageous. Biological DMARDs, particularly abatacept and tocilizumab, have evidence for good efficacy and acceptable safety profiles. Emerging evidence supports the use of JAK inhibitors. Biosimilars were reported to have efficacy and safety comparable to those of originator biologics in observational studies. Limited evidence suggests that gradual medication tapering after achieving inactive disease status reduces the risk of flares. Evidence for physiotherapy, occupational therapy, and complementary medicine was of very low certainty due to methodological heterogeneity.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>This SLR offers new evidence to support region\u2010specific clinical practice in JIA. While many findings support global recommendations, important evidence gaps remain, particularly in tapering, biosimilar use, TMJ management, and non\u2010pharmacological therapies. These insights will directly inform APLAR's upcoming clinical practice guideline for pcJIA and TMJ arthritis.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/1756-185x.70639","type":"journal-article","created":{"date-parts":[[2026,4,13]],"date-time":"2026-04-13T06:38:54Z","timestamp":1776062334000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Management of Polyarticular Course Juvenile Idiopathic Arthritis and Temporomandibular Joint Arthritis: A Systematic Literature Review and Meta\u2010Analysis Informing the\n                    <scp>APLAR<\/scp>\n                    Consensus Recommendations"],"prefix":"10.1111","volume":"29","author":[{"given":"Kai Liang","family":"Teh","sequence":"first","affiliation":[{"name":"Rheumatology and Immunology Service KK Women's and Children's Hospital  Singapore Singapore"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mariel B.","family":"Valmonte","sequence":"additional","affiliation":[{"name":"Bataan General Hospital  Balanga City Bataan Philippines"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Taqdees","family":"Khaliq","sequence":"additional","affiliation":[{"name":"Rheumatology Service Federal Government Polyclinic Hospital  Islamabad Pakistan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ma Theresa","family":"Collante","sequence":"additional","affiliation":[{"name":"University of Santo Tomas Hospital  Manila Philippines"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chester Junjie","family":"Huang","sequence":"additional","affiliation":[{"name":"Rheumatology and Immunology Service KK Women's and Children's Hospital  Singapore Singapore"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chao\u2010Yi","family":"Wu","sequence":"additional","affiliation":[{"name":"Division of Allergy, Asthma and Rheumatology, Department of Pediatrics Chang Gung Memorial Hospital  Taoyuan Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3161-848X","authenticated-orcid":false,"given":"Pauline Poh Lin","family":"Chan","sequence":"additional","affiliation":[{"name":"Department of Paediatrics, Khoo Teck Phuat\u2010National University Children's Medical Institute National University Health System  Singapore Singapore"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Butsabong","family":"Lerkvaleekul","sequence":"additional","affiliation":[{"name":"Division of Rheumatology, Department of Pediatrics, Faculty of Medicine Ramathibodi Hospital Mahidol University  Bangkok Thailand"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6824-8788","authenticated-orcid":false,"given":"Watchareewan","family":"Sontichai","sequence":"additional","affiliation":[{"name":"Division of Rheumatology, Department of Pediatrics, Faculty of Medicine Chiang Mai University  Chiang Mai Thailand"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Narendra Kumar","family":"Bagri","sequence":"additional","affiliation":[{"name":"Pediatric Rheumatology, Department of Pediatrics All India Institute of Medical Sciences  New Delhi India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marian Crisal M.","family":"Celindro\u2010Chan","sequence":"additional","affiliation":[{"name":"Institute of Pediatrics and Child Health St. Luke's Medical Center Quezon City  Manila Philippines"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria Janina H.","family":"Lebrudo","sequence":"additional","affiliation":[{"name":"Department of Pediatrics Manila Doctors Hospital  Manila Philippines"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sern Chin","family":"Lim","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, Faculty of Medicine Universiti Teknologi MARA (UiTM)  Shah Alam Malaysia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9711-7189","authenticated-orcid":false,"given":"Kosar","family":"Asnasshari","sequence":"additional","affiliation":[{"name":"Department of Pediatrics Tehran University of Medical Sciences  Tehran Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carla Marie","family":"Asis","sequence":"additional","affiliation":[{"name":"Division of Pediatric Rheumatology, Department of Pediatrics, Philippine General Hospital University of the Philippines College of Medicine  Manila Philippines"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nathalie Gail U.","family":"Choi","sequence":"additional","affiliation":[{"name":"Institute of Pediatrics and Child Health St. Luke's Medical Center Quezon City  Manila Philippines"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Leonila","family":"Dans","sequence":"additional","affiliation":[{"name":"Program on Health Systems Development \u2010 Philippine Primary Care Studies, Center for Integrative and Development Studies University of the Philippines Diliman  Quezon City Philippines"},{"name":"Clinical Epidemiology University of the Philippines Manila College of Medicine  Manila Philippines"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thaschawee","family":"Arkachaisri","sequence":"additional","affiliation":[{"name":"Rheumatology and Immunology Service KK Women's and Children's Hospital  Singapore Singapore"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,4,12]]},"reference":[{"issue":"2","key":"e_1_2_13_2_1","first-page":"390","article-title":"International League of Associations for Rheumatology Classification of Juvenile Idiopathic Arthritis: Second Revision, Edmonton, 2001","volume":"31","author":"Petty R. E.","year":"2004","journal-title":"Journal of Rheumatology"},{"key":"e_1_2_13_3_1","doi-asserted-by":"publisher","DOI":"10.1097\/MD.0000000000037567"},{"key":"e_1_2_13_4_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMra2402073"},{"issue":"3","key":"e_1_2_13_5_1","first-page":"390","article-title":"Paediatric Rheumatology Clinic Population in Southeast Asia: Are We Different?","volume":"56","author":"Arkachaisri T.","year":"2017","journal-title":"Rheumatology"},{"key":"e_1_2_13_6_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.n71"},{"key":"e_1_2_13_7_1","article-title":"PRISMA 2020 Explanation and Elaboration: Updated Guidance and Exemplars for Reporting Systematic Reviews","volume":"372","author":"Page M. J.","year":"2021","journal-title":"BMJ"},{"key":"e_1_2_13_8_1","doi-asserted-by":"publisher","DOI":"10.1503\/cmaj.090449"},{"key":"e_1_2_13_9_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1398-9995.2009.01973.x"},{"key":"e_1_2_13_10_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmjebm-2022-112102"},{"issue":"1","key":"e_1_2_13_11_1","first-page":"49","article-title":"Piroxicam in Juvenile Rheumatoid Arthritis","volume":"8","author":"Garc\u00eda\u2010Morteo O.","year":"1987","journal-title":"European Journal of Rheumatology and Inflammation"},{"issue":"5","key":"e_1_2_13_12_1","first-page":"1079","article-title":"High Response Rate in the Phase I\/II Study of Meloxicam in Juvenile Rheumatoid Arthritis","volume":"29","author":"Foeldvari I.","year":"2002","journal-title":"Journal of Rheumatology"},{"key":"e_1_2_13_13_1","doi-asserted-by":"publisher","DOI":"10.3899\/jrheum.080073"},{"key":"e_1_2_13_14_1","doi-asserted-by":"publisher","DOI":"10.1093\/rheumatology\/keab914"},{"key":"e_1_2_13_15_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12969\u2010017\u20100138\u20104"},{"key":"e_1_2_13_16_1","doi-asserted-by":"publisher","DOI":"10.1136\/annrheumdis\u20102018\u2010213902"},{"key":"e_1_2_13_17_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12969\u2010023\u201000874\u2010z"},{"key":"e_1_2_13_18_1","doi-asserted-by":"publisher","DOI":"10.5114\/reum\/161317"},{"key":"e_1_2_13_19_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12969\u2010019\u20100319\u20104"},{"key":"e_1_2_13_20_1","doi-asserted-by":"publisher","DOI":"10.1002\/acr.25156"},{"key":"e_1_2_13_21_1","doi-asserted-by":"publisher","DOI":"10.1002\/acr.24989"},{"key":"e_1_2_13_22_1","doi-asserted-by":"publisher","DOI":"10.1002\/art.40466"},{"key":"e_1_2_13_23_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13075\u2010020\u201002303\u2010y"},{"key":"e_1_2_13_24_1","doi-asserted-by":"publisher","DOI":"10.1002\/acr.24384"},{"key":"e_1_2_13_25_1","doi-asserted-by":"publisher","DOI":"10.1136\/annrheumdis\u20102014\u2010205351"},{"key":"e_1_2_13_26_1","doi-asserted-by":"publisher","DOI":"10.1093\/rheumatology\/kez291"},{"key":"e_1_2_13_27_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10067\u2010008\u20100995\u20109"},{"key":"e_1_2_13_28_1","doi-asserted-by":"publisher","DOI":"10.1093\/rheumatology\/key306"},{"key":"e_1_2_13_29_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12969\u2010020\u201000488\u20109"},{"key":"e_1_2_13_30_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12969\u2010019\u20100370\u20101"},{"key":"e_1_2_13_31_1","doi-asserted-by":"publisher","DOI":"10.1136\/ard.2010.143347"},{"key":"e_1_2_13_32_1","doi-asserted-by":"publisher","DOI":"10.1002\/art.41888"},{"key":"e_1_2_13_33_1","doi-asserted-by":"publisher","DOI":"10.1080\/03009742.2018.1488182"},{"key":"e_1_2_13_34_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140\u20106736(21)01255\u20101"},{"key":"e_1_2_13_35_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140\u20106736(23)00921\u20102"},{"key":"e_1_2_13_36_1","doi-asserted-by":"publisher","DOI":"10.1002\/acr.25465"},{"key":"e_1_2_13_37_1","doi-asserted-by":"publisher","DOI":"10.1111\/1756\u2010185X.14324"},{"key":"e_1_2_13_38_1","doi-asserted-by":"publisher","DOI":"10.1002\/art.21384"},{"key":"e_1_2_13_39_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.joms.2017.12.030"},{"key":"e_1_2_13_40_1","doi-asserted-by":"publisher","DOI":"10.1093\/rheumatology\/kes318"},{"key":"e_1_2_13_41_1","doi-asserted-by":"publisher","DOI":"10.3899\/jrheum.150308"},{"key":"e_1_2_13_42_1","doi-asserted-by":"publisher","DOI":"10.15537\/SMJ.2021.42.4.20200470"},{"key":"e_1_2_13_43_1","doi-asserted-by":"publisher","DOI":"10.1002\/art.24516"},{"key":"e_1_2_13_44_1","doi-asserted-by":"publisher","DOI":"10.1136\/annrheumdis\u20102011\u2010200237"},{"key":"e_1_2_13_45_1","doi-asserted-by":"publisher","DOI":"10.1002\/acr.22393"},{"key":"e_1_2_13_46_1","doi-asserted-by":"publisher","DOI":"10.1093\/rap\/rky044"},{"key":"e_1_2_13_47_1","doi-asserted-by":"publisher","DOI":"10.1093\/rheumatology\/kev353"},{"key":"e_1_2_13_48_1","doi-asserted-by":"publisher","DOI":"10.1002\/art.41879"},{"key":"e_1_2_13_49_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2010.375"},{"key":"e_1_2_13_50_1","doi-asserted-by":"publisher","DOI":"10.1002\/msc.1239"},{"key":"e_1_2_13_51_1","doi-asserted-by":"publisher","DOI":"10.3390\/cells13050442"},{"key":"e_1_2_13_52_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12969\u2010021\u201000527\u2010z"},{"key":"e_1_2_13_53_1","doi-asserted-by":"publisher","DOI":"10.1136\/ard.2003.005686"},{"key":"e_1_2_13_54_1","doi-asserted-by":"publisher","DOI":"10.1136\/annrheumdis\u20102017\u2010211968"},{"key":"e_1_2_13_55_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00296\u2010022\u201005108\u20101"},{"key":"e_1_2_13_56_1","doi-asserted-by":"publisher","DOI":"10.20953\/1817\u20107646\u20102023\u20102\u201022\u201036"},{"key":"e_1_2_13_57_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10067\u2010024\u201006928\u20101"},{"key":"e_1_2_13_58_1","doi-asserted-by":"publisher","DOI":"10.1002\/acr.22477"},{"key":"e_1_2_13_59_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.pedhc.2024.08.003"},{"key":"e_1_2_13_60_1","doi-asserted-by":"publisher","DOI":"10.1016\/S2665\u20109913(24)00087\u20100"},{"key":"e_1_2_13_61_1","doi-asserted-by":"publisher","DOI":"10.1093\/rheumatology\/keab572"},{"key":"e_1_2_13_62_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00296\u2010020\u201004774\u20103"},{"key":"e_1_2_13_63_1","doi-asserted-by":"publisher","DOI":"10.1080\/14712598.2022.2123703"},{"key":"e_1_2_13_64_1","doi-asserted-by":"publisher","DOI":"10.1093\/rheumatology\/keg386"},{"key":"e_1_2_13_65_1","doi-asserted-by":"publisher","DOI":"10.2340\/16501977\u20101051"},{"key":"e_1_2_13_66_1","doi-asserted-by":"publisher","DOI":"10.1186\/1546\u20100096\u201011\u20107"},{"key":"e_1_2_13_67_1","doi-asserted-by":"publisher","DOI":"10.1002\/art.23008"},{"key":"e_1_2_13_68_1","doi-asserted-by":"publisher","DOI":"10.2340\/16501977\u20101130"},{"key":"e_1_2_13_69_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12969-018-0283-4"},{"key":"e_1_2_13_70_1","doi-asserted-by":"publisher","DOI":"10.1002\/1529\u20100131(199902)12:1<52::aid\u2010art9>3.0.co;2\u2010x"},{"issue":"5","key":"e_1_2_13_71_1","first-page":"943","article-title":"Efficacy of Custom Foot Orthotics in Improving Pain and Functional Status in Children With Juvenile Idiopathic Arthritis: A Randomized Trial","volume":"32","author":"Powell M.","year":"2005","journal-title":"Journal of Rheumatology"},{"key":"e_1_2_13_72_1","doi-asserted-by":"publisher","DOI":"10.1093\/jpepsy\/22.5.607"},{"key":"e_1_2_13_73_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ctim.2021.102696"},{"key":"e_1_2_13_74_1","doi-asserted-by":"publisher","DOI":"10.3892\/etm.2019.8133"},{"key":"e_1_2_13_75_1","doi-asserted-by":"publisher","DOI":"10.1620\/tjem.237.183"},{"issue":"4","key":"e_1_2_13_76_1","first-page":"317","article-title":"Radix Tripterygium Wilfordii Hook F in Rheumatoid Arthritis, Ankylosing Spondylitis and Juvenile Rheumatoid Arthritis","volume":"99","author":"Gao Z. G.","year":"1986","journal-title":"Chinese Medical Journal"},{"key":"e_1_2_13_77_1","doi-asserted-by":"publisher","DOI":"10.1089\/jmf.2013.0169"},{"key":"e_1_2_13_78_1","doi-asserted-by":"publisher","DOI":"10.1002\/art.1790050209"},{"key":"e_1_2_13_79_1","doi-asserted-by":"publisher","DOI":"10.3899\/jrheum.081295"},{"key":"e_1_2_13_80_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12969-018-0255-8"},{"key":"e_1_2_13_81_1","doi-asserted-by":"publisher","DOI":"10.1002\/art.40884"},{"key":"e_1_2_13_82_1","article-title":"Tumor Necrosis Factor (TNF) Inhibitors for Juvenile Idiopathic Arthritis","volume":"2","author":"Cagnotto G.","year":"2025","journal-title":"Cochrane Database of Systematic Reviews"},{"key":"e_1_2_13_83_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10067-018-4304-y"},{"key":"e_1_2_13_84_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2012-04-425744"},{"issue":"5","key":"e_1_2_13_85_1","article-title":"Therapeutic Equivalence of Biosimilar and Reference Biologic Drugs in Rheumatoid Arthritis: A Systematic Review and Meta\u2010Analysis","volume":"6","author":"Oliveira Ascef B.","year":"2023","journal-title":"JAMA Network Open"},{"key":"e_1_2_13_86_1","doi-asserted-by":"publisher","DOI":"10.1080\/14397595.2021.1899591"},{"key":"e_1_2_13_87_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13643-024-02715-w"},{"key":"e_1_2_13_88_1","doi-asserted-by":"publisher","DOI":"10.1002\/art.34373"},{"key":"e_1_2_13_89_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11926-017-0702-4"}],"container-title":["International Journal of Rheumatic Diseases"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/1756-185x.70639","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/1756-185x.70639","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/1756-185x.70639","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,10,20]],"date-time":"2026-10-20T06:56:33Z","timestamp":1792479393000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/1756-185x.70639"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,4]]},"references-count":88,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2026,4]]}},"alternative-id":["10.1111\/1756-185x.70639"],"URL":"https:\/\/doi.org\/10.1111\/1756-185x.70639","archive":["Portico"],"relation":{},"ISSN":["1756-1841","1756-185X"],"issn-type":[{"value":"1756-1841","type":"print"},{"value":"1756-185X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,4]]},"assertion":[{"value":"2025-12-05","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-03-30","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-04-12","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e70639"}}