{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,20]],"date-time":"2026-10-20T07:39:28Z","timestamp":1792481968463,"version":"4.5.0"},"reference-count":21,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2026,4,13]],"date-time":"2026-04-13T00:00:00Z","timestamp":1776038400000},"content-version":"vor","delay-in-days":12,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,4,1]],"date-time":"2026-04-01T00:00:00Z","timestamp":1775001600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Int J of Rheum Dis"],"published-print":{"date-parts":[[2026,4]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>The objective of this study is to perform a cross\u2010cultural validation of the Work Productivity and Activity Impairment (WPAI\u2010Lupus v2.0) questionnaire in Latin American individuals with systemic lupus erythematosus (SLE), using data from the GLADEL cohort.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      GLADEL 2.0 is an observational cohort of SLE patients \u2265\u200918\u2009years old. Clinical data, disease activity (SLEDAI\u20102\u2009K), damage index (SDI), physician's global assessment (PGA) and patient\u2010reported outcomes (WPAI\u2010Lupus v2.0, LupusQoL), were assessed at baseline and during follow\u2010up. Construct validity was evaluated through Spearman correlations with SLEDAI\u20102\u2009K, SDI and LupusQoL. Internal consistency was assessed using Cronbach's alpha and responsiveness over 12\u2009months was analyzed using the Wilcoxon signed\u2010rank test. Appropriate statistical tests (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.05) were performed using R software, version 4.4.0.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Among 1083 patients, 684 were evaluated at baseline and at 12\u2009months. Cronbach's alpha values were: absenteeism 0.54; presenteeism 0.64; overall work impairment 0.62; activity impairment 0.62. WPAI\u2010Lupus v2.0 scores correlated with SLEDAI\u20102\u2009K (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.001) and negatively with LupusQoL domains. Moderate correlations were observed between activity impairment and physical health, pain and planning (\n                      <jats:italic>r<\/jats:italic>\n                      \u2009\u2248\u2009\u22120.52 to \u22120.58). Presenteeism and overall work impairment also showed moderate correlations with physical health and pain domains (\n                      <jats:italic>r<\/jats:italic>\n                      \u2009\u2248\u2009\u22120.49 to \u22120.53). WPAI\u2010Lupus v2.0 was sensitive to change over 12\u2009months (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.001) for all domains except intimate relationship.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>WPAI\u2010Lupus v2.0 demonstrated good validity, internal consistency, and responsiveness. It correlated with disease activity and quality of life, supporting the WPAI\u2010Lupus v2.0 as a valid tool to assess work and activity impairment in Latin American patients with SLE.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/1756-185x.70641","type":"journal-article","created":{"date-parts":[[2026,4,14]],"date-time":"2026-04-14T02:08:01Z","timestamp":1776132481000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Cross Cultural Validation of Work Productivity and Activity Impairment Questionnaire in Lupus Patients From Latin America"],"prefix":"10.1111","volume":"29","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2895-3060","authenticated-orcid":false,"given":"Romina E.","family":"Nieto","sequence":"first","affiliation":[{"name":"Centro Regional de Enfermedades Autoinmunes y Reum\u00e1ticas. GO\u2010CREAR  Rosario Argentina"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lucia","family":"Hern\u00e1ndez","sequence":"additional","affiliation":[{"name":"GLADEL External Consultant  Rosario Argentina"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rosana","family":"Quintana","sequence":"additional","affiliation":[{"name":"Centro Regional de Enfermedades Autoinmunes y Reum\u00e1ticas. 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