{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,26]],"date-time":"2026-05-26T06:04:02Z","timestamp":1779775442064,"version":"3.53.1"},"reference-count":58,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2026,5,7]],"date-time":"2026-05-07T00:00:00Z","timestamp":1778112000000},"content-version":"vor","delay-in-days":6,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T00:00:00Z","timestamp":1777593600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Int J of Rheum Dis"],"published-print":{"date-parts":[[2026,5]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    Women bear a disproportionate burden of knee osteoarthritis (KOA), yet global research systematically underrepresents sex\u2010specific and context\u2010sensitive analyses, limiting precision care and equitable interventions. We conducted a scoping review following PRISMA\u2010ScR guidelines, systematically mapping studies on KOA in adults from 2000 to 2024 across PubMed, Embase, Scopus, Web of Science, and Cochrane Library. A predefined, version\u2010controlled protocol was maintained with timestamped revisions and an independent audit to ensure methodological transparency. Dual independent screening, data extraction, and coding achieved high reliability (Cohen's \u03ba\u2009=\u20090.87). A validated weighted gap scoring system assessed four equity domains: sex\u2010disaggregated analysis, women's representation, contextual reporting, and geographic diversity. Integrated descriptive mapping and cross\u2010tabulation quantified structural evidence gaps. Gray literature and non\u2010English studies were excluded, acknowledging potential underrepresentation of low\u2010 and middle\u2010income country (LMIC) data. Among 287 included studies, women were represented in 91%, yet only 22% were women\u2010only cohorts, with high\u2010income countries 2.4\u00d7 more likely to conduct women\u2010focused research than LMICs (\u03c7\n                    <jats:sup>2<\/jats:sup>\n                    \u2009=\u200929.4,\n                    <jats:italic>p<\/jats:italic>\n                    \u2009&lt;\u20090.001). Sex\u2010disaggregated analyses were reported in 38% of mixed\u2010sex studies, with profound neglect of psychosocial, preventive, and mechanistic outcomes. Intersectional analyses combining age, socioeconomic status, and context were extremely rare. Weighted gap scores highlighted very high deficiencies in SES, education, occupation, and LMIC representation, with minimal improvement over 24\u2009years. KOA's evidence base does not merely underrepresent women; it systematically fails to generate clinically validated knowledge for them. As a result, interventions are routinely applied without clear evidence of the effectiveness across the population most affected, without mandatory sex\u2010aggregated, mechanistic, and context\u2010specific research.\n                  <\/jats:p>","DOI":"10.1111\/1756-185x.70657","type":"journal-article","created":{"date-parts":[[2026,5,7]],"date-time":"2026-05-07T10:10:43Z","timestamp":1778148643000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Women's Knees Are Not Gender\u2010Neutral: A Global Scoping Review of Equity, Representation, and Context in Knee Osteoarthritis Research and Evidence"],"prefix":"10.1111","volume":"29","author":[{"ORCID":"https:\/\/orcid.org\/0009-0002-2295-6970","authenticated-orcid":false,"given":"Emmanuel Okon","family":"Enang","sequence":"first","affiliation":[{"name":"Department of Physiotherapy University of Calabar  Calabar Nigeria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ezra Onyedikachi","family":"Madu","sequence":"additional","affiliation":[{"name":"Department of Nursing Sciences State University of Medical and Applied Sciences  Enugu Nigeria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Minha","family":"Awan","sequence":"additional","affiliation":[{"name":"Department of Physiotherapy Bahawalpur Medical and Dental College (BMDC)  Bahawalpur Pakistan"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,5,7]]},"reference":[{"key":"e_1_2_12_2_1","doi-asserted-by":"publisher","DOI":"10.1136\/annrheumdis\u20102019\u2010216515"},{"key":"e_1_2_12_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140\u20106736(20)30925\u20109"},{"key":"e_1_2_12_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.joca.2005.04.014"},{"key":"e_1_2_12_5_1","doi-asserted-by":"publisher","DOI":"10.1002\/art.39600"},{"key":"e_1_2_12_6_1","doi-asserted-by":"publisher","DOI":"10.1002\/art.22214"},{"issue":"120","key":"e_1_2_12_7_1","first-page":"3","article-title":"Osteoarthritis is a Serious Disease","volume":"37","author":"Hawker G. 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