{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,20]],"date-time":"2026-10-20T07:39:13Z","timestamp":1792481953714,"version":"4.5.0"},"reference-count":55,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2026,4,17]],"date-time":"2026-04-17T00:00:00Z","timestamp":1776384000000},"content-version":"vor","delay-in-days":16,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,4,1]],"date-time":"2026-04-01T00:00:00Z","timestamp":1775001600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Int J of Rheum Dis"],"published-print":{"date-parts":[[2026,4]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Aim<\/jats:title>\n                    <jats:p>To summarize the evidence of efficacy and safety of romosozumab compared to teriparatide for postmenopausal osteoporosis.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>A literature search was performed in Medline, the Cochrane Library, CRD, and LILACS until November 2023. We included systematic reviews with meta\u2010analyses on the use of romosozumab compared to teriparatide in women with postmenopausal osteoporosis. Two authors performed study selection, data extraction, and quality assessment using AMSTAR\u20102 and GRADE tools.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>A total of 725 records were identified, and 13 studies fully met the eligibility criteria. Regarding efficacy, romosozumab did not show a significant difference in risk of falls (12\/24\u2009months), vertebral fractures (12\/36\u2009months), non\u2010vertebral fractures (12\/36\u2009months), and hip fractures compared to teriparatide. For the safety profile, romosozumab did not show significant change compared to teriparatide for serious adverse events (12\/26\u2009months) and composite cardiovascular outcomes (3PMACE and 4PMACE). The overall quality of evidence in the reviews ranged from very low to moderate, primarily due to indirectness and imprecision in the outcomes. Additionally, the reviews were classified as having \u201clow\u201d or \u201ccritically low\u201d methodological quality.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Romosozumab demonstrated efficacy and safety similar to teriparatide. However, this overview revealed substantial overlap among primary studies, with most outcomes assessed through indirect comparisons and poor methodological quality. Future research should confirm these findings.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/1756-185x.70658","type":"journal-article","created":{"date-parts":[[2026,4,18]],"date-time":"2026-04-18T05:29:47Z","timestamp":1776490187000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Romosozumab Versus Teriparatide for the Treatment of Postmenopausal Osteoporosis: An Overview of Systematic Reviews With Direct and Indirect Meta\u2010Analyses"],"prefix":"10.1111","volume":"29","author":[{"ORCID":"https:\/\/orcid.org\/0009-0001-5032-8325","authenticated-orcid":false,"given":"Tayna Felicissimo Gomes de Souza","family":"Bandeira","sequence":"first","affiliation":[{"name":"Faculty of Pharmacy Fluminense Federal University  Niteroi RJ Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3957-4533","authenticated-orcid":false,"given":"Patricia Melo","family":"Aguiar","sequence":"additional","affiliation":[{"name":"Department of Pharmacy, Faculty of Pharmaceutical Sciences University of Sao Paulo  Sao Paulo SP Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0252-1144","authenticated-orcid":false,"given":"Cid Manso de Mello","family":"Vianna","sequence":"additional","affiliation":[{"name":"Institute of Social Medicine State University of Rio de Janeiro (UERJ)  Rio de Janeiro RJ Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5954-684X","authenticated-orcid":false,"given":"Gabriela Bittencourt Gonzalez","family":"Mosegui","sequence":"additional","affiliation":[{"name":"Institute of Collective Health Fluminense Federal University  Niteroi RJ Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4395-2098","authenticated-orcid":false,"given":"T\u00e1cio de Mendon\u00e7a","family":"Lima","sequence":"additional","affiliation":[{"name":"Department of Pharmacy and Pharmaceutical Administration Fluminense Federal University  Niteroi RJ Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,4,17]]},"reference":[{"key":"e_1_2_12_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ecl.2012.04.006"},{"key":"e_1_2_12_3_1","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2019\u201000192"},{"key":"e_1_2_12_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/S2666\u20107568(21)00172\u20100"},{"key":"e_1_2_12_5_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00198\u2010022\u201006454\u20103"},{"key":"e_1_2_12_6_1","doi-asserted-by":"publisher","DOI":"10.4158\/GL\u20102020\u20100524SUPPL"},{"key":"e_1_2_12_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/S2213\u20108587(17)30188\u20102"},{"key":"e_1_2_12_8_1","doi-asserted-by":"publisher","DOI":"10.3310\/hta24290"},{"key":"e_1_2_12_9_1","doi-asserted-by":"publisher","DOI":"10.1097\/GME.0000000000001831"},{"key":"e_1_2_12_10_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00198\u2010018\u20104704\u20105"},{"key":"e_1_2_12_11_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmj\u20102022\u2010070849"},{"key":"e_1_2_12_12_1","unstructured":"A. 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