{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,26]],"date-time":"2026-05-26T06:04:11Z","timestamp":1779775451031,"version":"3.53.1"},"reference-count":14,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2026,5,9]],"date-time":"2026-05-09T00:00:00Z","timestamp":1778284800000},"content-version":"vor","delay-in-days":8,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T00:00:00Z","timestamp":1777593600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Int J of Rheum Dis"],"published-print":{"date-parts":[[2026,5]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Updated, country\u2010specific burden curves for rheumatoid arthritis (RA) across the Asia\u2010Pacific region remain limited. We aimed to quantify long\u2010term trends in RA prevalence, incidence, mortality, and disability\u2010adjusted life\u2010years (DALYs) from 1990 to 2023, and to project short\u2010term burden to 2025.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>We extracted age\u2010standardized rates (ASRs) and absolute counts for rheumatoid arthritis from the Global Burden of Disease (GBD) 2023 study for 27 Asia\u2010Pacific countries and territories. Temporal trends were summarized using average annual percent change (AAPC) estimated from joinpoint regression, and short\u2010term projections to 2025 were generated using Bayesian age\u2010period\u2010cohort models. Decomposition analysis quantified the relative contributions of population aging, population growth, and changes in age\u2010specific rates to observed increases in prevalent cases.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Between 1990 and 2023, the regional age\u2010standardized prevalence rate of rheumatoid arthritis increased by approximately 16%, reaching 126 per 100\u2009000 population in 2023, and is projected to rise further to 131 per 100\u2009000 (95% uncertainty interval [UI] 124\u2013138) by 2025. Age\u2010standardized incidence increased from 10.0 to 11.6 per 100\u2009000, with a projected rate of 12.1 per 100\u2009000 (95% UI 11.2\u201313.0) in 2025. In contrast, age\u2010standardized mortality declined by 43% (from 0.75 to 0.43 per 100\u2009000), and DALY rates decreased modestly (from 45.3 to 41.8 per 100\u2009000), although absolute DALYs increased due to demographic expansion. Decomposition analysis indicated that 84% of the net increase in prevalent RA cases was attributable to population aging and growth, with only 16% associated with rising age\u2010specific prevalence rates. Female\u2010to\u2010male prevalence ratios remained stable at approximately 2.3\u20132.4 throughout the study period. The fastest relative increases were observed in lower\u2010middle\u2010income South\u2010East Asian countries, while several high\u2010income Western\u2010Pacific countries showed stable or declining rates.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>The expanding burden of rheumatoid arthritis in the Asia\u2010Pacific region is driven predominantly by demographic momentum rather than worsening per\u2010capita risk. Although mortality and per\u2010capita disability are declining, absolute health loss will continue to rise under population aging. Integrating early RA care with population\u2010level prevention targeting modifiable risk factors may mitigate future burden growth.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/1756-185x.70674","type":"journal-article","created":{"date-parts":[[2026,5,10]],"date-time":"2026-05-10T03:29:41Z","timestamp":1778383781000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Epidemiology of Rheumatoid Arthritis in the Asia\u2010Pacific Region: A Systematic Analysis of the Global Burden of Disease Study 1990\u20132023 and Forecasts to 2025"],"prefix":"10.1111","volume":"29","author":[{"given":"Shuyi","family":"Song","sequence":"first","affiliation":[{"name":"Department of Rheumatology Affiliated Hospital of Qingdao University  Qingdao Shandong China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2064-8440","authenticated-orcid":false,"given":"Lin","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Epidemiology and Preventive Medicine, The School of Public Health and Preventive Medicine Monash University  Melbourne Victoria Australia"},{"name":"Suzhou Industrial Park Monash Research Institute of Science and Technology Monash University  Suzhou Jiangsu China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0938-6168","authenticated-orcid":false,"given":"Jibo","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Rheumatology Affiliated Hospital of Qingdao University  Qingdao Shandong China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,5,9]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(16)30173-8"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1136\/annrheumdis-2013-204627"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(20)30925-9"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.1136\/annrheumdis-2019-215920"},{"key":"e_1_2_10_6_1","volume-title":"World Population Prospects 2022","year":"2022"},{"key":"e_1_2_10_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(14)60460-8"},{"key":"e_1_2_10_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(20)30752-2"},{"key":"e_1_2_10_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(18)32279-7"},{"key":"e_1_2_10_10_1","doi-asserted-by":"publisher","DOI":"10.1002\/art.27584"},{"key":"e_1_2_10_11_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13075-015-0601-x"},{"key":"e_1_2_10_12_1","doi-asserted-by":"publisher","DOI":"10.1002\/acr.22783"},{"key":"e_1_2_10_13_1","doi-asserted-by":"publisher","DOI":"10.1136\/ard-2022-223356"},{"key":"e_1_2_10_14_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.k1036"},{"key":"e_1_2_10_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2020.11.010"}],"container-title":["International Journal of Rheumatic Diseases"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/1756-185x.70674","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/1756-185x.70674","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/1756-185x.70674","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,5,26]],"date-time":"2026-05-26T05:32:39Z","timestamp":1779773559000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/1756-185x.70674"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,5]]},"references-count":14,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2026,5]]}},"alternative-id":["10.1111\/1756-185x.70674"],"URL":"https:\/\/doi.org\/10.1111\/1756-185x.70674","archive":["Portico"],"relation":{},"ISSN":["1756-1841","1756-185X"],"issn-type":[{"value":"1756-1841","type":"print"},{"value":"1756-185X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,5]]},"assertion":[{"value":"2026-01-19","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-04-18","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-05-09","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e70674"}}