{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,23]],"date-time":"2026-09-23T08:00:41Z","timestamp":1790150441484,"version":"4.0.1"},"reference-count":21,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T00:00:00Z","timestamp":1788220800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T00:00:00Z","timestamp":1788220800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Int J of Rheum Dis"],"published-print":{"date-parts":[[2026,9]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>\n                      Rheumatoid Arthritis (\n                      <jats:styled-content style=\"fixed-case\">RA<\/jats:styled-content>\n                      ) is a Prevalent Autoimmune Disorder Affecting Millions of People Worldwide. A Thorough Understanding of Its Clinical and Pathological Features Is Essential to Improve Patient Outcomes.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      This Study Combined Data\u2010Independent Acquisition Proteomics and Enzyme\u2010Linked Immunosorbent Assay (\n                      <jats:styled-content style=\"fixed-case\">ELISA<\/jats:styled-content>\n                      ) to Identify and Validate Potential Plasma Protein Biomarkers for the Early Diagnosis of\n                      <jats:styled-content style=\"fixed-case\">RA.<\/jats:styled-content>\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Differential Proteomic Analysis Identified Differentially Expressed Proteins Between Patients With\n                      <jats:styled-content style=\"fixed-case\">RA<\/jats:styled-content>\n                      and Healthy Controls and Characterized Their Functions. Gene Ontology and Kyoto Encyclopedia of Genes and Genomes Enrichment Analyses Were Performed to Explore Protein Functions and Associated Biological Pathways. The\n                      <jats:styled-content style=\"fixed-case\">STRING<\/jats:styled-content>\n                      Database and the Metascape Platform Were Used to Conduct an in\u2010Depth Analysis of the Protein\u2013Protein Interaction Network, Highlighting the Functional Attributes and Interconnections of Upregulated Proteins and Identifying Key Protein Complexes Involved in\n                      <jats:styled-content style=\"fixed-case\">RA<\/jats:styled-content>\n                      .\n                      <jats:styled-content style=\"fixed-case\">ELISA<\/jats:styled-content>\n                      Analysis of Plasma Samples Revealed Significantly Elevated\n                      <jats:styled-content style=\"fixed-case\">SERPINA3<\/jats:styled-content>\n                      Levels in Patients With\n                      <jats:styled-content style=\"fixed-case\">RA<\/jats:styled-content>\n                      , Which Were Positively Correlated With Disease Activity Indicators\u2014Including Erythrocyte Sedimentation Rate, C\u2010Reactive Protein, and Disease Activity Score 28\u2014But Were Not Correlated With Rheumatoid Factor or Its Subtypes.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>\n                      This Study Provides New Insights and Identifies Potential Biomarkers for the Early Diagnosis of\n                      <jats:styled-content style=\"fixed-case\">RA.<\/jats:styled-content>\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/1756-185x.70766","type":"journal-article","created":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T08:47:46Z","timestamp":1788252466000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["A Comprehensive Analysis of Differential Protein Expression in the Plasma of Rheumatoid Arthritis Patients Utilizing Data\u2010Independent Acquisition (\n                    <scp>DIA<\/scp>\n                    ) Proteomics Technology"],"prefix":"10.1111","volume":"29","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0711-6535","authenticated-orcid":false,"given":"Yang","family":"Zhao","sequence":"first","affiliation":[{"name":"Department of Rheumatology and Immunology Tianjin First Central Hospital  Tianjin China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuan","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Rheumatology and Immunology Tianjin First Central Hospital  Tianjin China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Meng","family":"Qi","sequence":"additional","affiliation":[{"name":"Department of Rheumatology and Immunology Tianjin First Central Hospital  Tianjin China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Junhua","family":"Xu","sequence":"additional","affiliation":[{"name":"Department of Rheumatology and Immunology Tianjin First Central Hospital  Tianjin China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fengwei","family":"Ji","sequence":"additional","affiliation":[{"name":"Department of Rheumatology and Immunology Tianjin First Central Hospital  Tianjin China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yan","family":"Kan","sequence":"additional","affiliation":[{"name":"Department of Rheumatology and Immunology Tianjin First Central Hospital  Tianjin China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chunyu","family":"Kong","sequence":"additional","affiliation":[{"name":"Department of Rheumatology and Immunology Tianjin First Central Hospital  Tianjin 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Stimulator or Inhibitor of Pathological Changes","volume":"11","author":"Mezer M.","year":"2023","journal-title":"Biomedicine"},{"key":"e_1_2_10_13_1","doi-asserted-by":"publisher","DOI":"10.1002\/mas.21781"},{"key":"e_1_2_10_14_1","doi-asserted-by":"publisher","DOI":"10.1002\/pmic.201900276"},{"key":"e_1_2_10_15_1","doi-asserted-by":"publisher","DOI":"10.1002\/pmic.202200046"},{"key":"e_1_2_10_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.molp.2020.06.009"},{"key":"e_1_2_10_17_1","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/gkac1000"},{"key":"e_1_2_10_18_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41467\u2010019\u201009234\u20106"},{"key":"e_1_2_10_19_1","first-page":"24","article-title":"Global Profiling of Lactylation Proteomics and Specific Lactylated Site Validation in Rheumatoid Arthritis Patients","volume":"4","author":"Hu J.","year":"2025","journal-title":"Journal of Proteome 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