{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,25]],"date-time":"2026-07-25T12:00:44Z","timestamp":1784980844198,"version":"3.55.0"},"reference-count":19,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2026,7,11]],"date-time":"2026-07-11T00:00:00Z","timestamp":1783728000000},"content-version":"vor","delay-in-days":10,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T00:00:00Z","timestamp":1782864000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/100010740","name":"Asahi Kasei Pharma Corporation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100010740","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Int J of Rheum Dis"],"published-print":{"date-parts":[[2026,7]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    High\u2010riding vertebral artery (HRVA) at C2 is more prevalent in patients with rheumatoid arthritis (RA) than in the general population, but its clinical significance remains unclear. Recent evidence in non\u2010RA individuals suggests that unilateral HRVA may contribute to atlantoaxial joint degeneration (AAJD) through asymmetric mechanical stress. This study investigated whether unilateral HRVA is similarly associated with the progression of AAJD in RA. We retrospectively analyzed 336 RA patients from the single institutional cohort who underwent CT scans, including C1\u2013C2, between 2011 and 2024. HRVA was defined as a C2 internal height &lt;\u20092\u2009mm and\/or isthmus height &lt;\u20095\u2009mm. Morphological parameters (C1 lateral mass height, C1\/2 coronal inclination, and C1\/2 relative rotation angle) and AAJD grades were evaluated. Logistic regression was used to identify factors associated with moderate\u2010to\u2010severe AAJD (grade \u2265\u20092). HRVA was observed in 147 patients (116 unilateral). Compared with patients without HRVA, those with unilateral HRVA had longer RA duration (17.5 vs. 12.9\u2009years,\n                    <jats:italic>p<\/jats:italic>\n                    \u2009&lt;\u20090.01) and higher ACPA positivity (78.8% vs. 66.9%,\n                    <jats:italic>p<\/jats:italic>\n                    \u2009&lt;\u20090.05), but no differences in disease activity or medication use. Moderate\u2010to\u2010severe AAJD was significantly more frequent in the unilateral HRVA group (62.9% vs. 42.3%,\n                    <jats:italic>p<\/jats:italic>\n                    \u2009&lt;\u20090.001). Multivariate analysis identified older age, longer RA duration, and unilateral HRVA as independent risk factors for AAJD. These findings indicate that unilateral HRVA is independently associated with atlantoaxial facet joint degeneration in patients with RA in addition to aging and disease duration, suggesting a role of asymmetric mechanical loading in cervical joint pathology.\n                  <\/jats:p>","DOI":"10.1111\/1756-185x.70771","type":"journal-article","created":{"date-parts":[[2026,7,11]],"date-time":"2026-07-11T07:53:17Z","timestamp":1783756397000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Unilateral High\u2010Riding Vertebral Artery Associates With the Progression of Atlantoaxial Joint Degeneration in Patients With Rheumatoid Arthritis"],"prefix":"10.1111","volume":"29","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7896-3937","authenticated-orcid":false,"given":"Koichi","family":"Murata","sequence":"first","affiliation":[{"name":"Department of Orthopaedic Surgery Kyoto University Graduate School of Medicine  Kyoto Japan"},{"name":"Department of Advanced Medicine for Rheumatic Diseases Kyoto University Graduate School of Medicine  Kyoto Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6556-1226","authenticated-orcid":false,"given":"Takayuki","family":"Fujii","sequence":"additional","affiliation":[{"name":"Department of Orthopaedic Surgery Kyoto University Graduate School of Medicine  Kyoto Japan"},{"name":"Department of Advanced Medicine for Rheumatic Diseases Kyoto University Graduate School of Medicine  Kyoto Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4749-7830","authenticated-orcid":false,"given":"Bungo","family":"Otsuki","sequence":"additional","affiliation":[{"name":"Department of Orthopaedic Surgery Kyoto University Graduate School of Medicine  Kyoto 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Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9250-1851","authenticated-orcid":false,"given":"Shuichiro","family":"Nakabo","sequence":"additional","affiliation":[{"name":"Department of Advanced Medicine for Rheumatic Diseases Kyoto University Graduate School of Medicine  Kyoto Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5981-4648","authenticated-orcid":false,"given":"Kosaku","family":"Murakami","sequence":"additional","affiliation":[{"name":"Division of Clinical Immunology and Cancer Immunotherapy, Center for Cancer Immunotherapy and Immunobiology Kyoto University Graduate School of Medicine  Kyoto Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8942-2933","authenticated-orcid":false,"given":"Masao","family":"Tanaka","sequence":"additional","affiliation":[{"name":"Department of Advanced Medicine for Rheumatic Diseases Kyoto University Graduate School of Medicine  Kyoto Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4672-638X","authenticated-orcid":false,"given":"Akio","family":"Morinobu","sequence":"additional","affiliation":[{"name":"Department of Rheumatology and Clinical Immunology Kyoto University Graduate School of Medicine  Kyoto Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0802-1255","authenticated-orcid":false,"given":"Shuichi","family":"Matsuda","sequence":"additional","affiliation":[{"name":"Department of Orthopaedic Surgery Kyoto University Graduate School of Medicine  Kyoto 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