{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,15]],"date-time":"2026-09-15T05:25:16Z","timestamp":1789449916151,"version":"build-2803163510"},"reference-count":35,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2026,8,5]],"date-time":"2026-08-05T00:00:00Z","timestamp":1785888000000},"content-version":"vor","delay-in-days":4,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,8,1]],"date-time":"2026-08-01T00:00:00Z","timestamp":1785542400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100004737","name":"National Health Research Institutes","doi-asserted-by":"publisher","award":["NHRI\u2010110A1\u2010MRCO\u201003212101"],"award-info":[{"award-number":["NHRI\u2010110A1\u2010MRCO\u201003212101"]}],"id":[{"id":"10.13039\/501100004737","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100011645","name":"Kaohsiung Medical University Chung-Ho Memorial Hospital","doi-asserted-by":"publisher","award":["KMUH\u2010DK(A)113005"],"award-info":[{"award-number":["KMUH\u2010DK(A)113005"]}],"id":[{"id":"10.13039\/501100011645","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100011645","name":"Kaohsiung Medical University Chung-Ho Memorial Hospital","doi-asserted-by":"publisher","award":["KMUHS11314"],"award-info":[{"award-number":["KMUHS11314"]}],"id":[{"id":"10.13039\/501100011645","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100011645","name":"Kaohsiung Medical University Chung-Ho Memorial Hospital","doi-asserted-by":"publisher","award":["KMUH114\u20104R25"],"award-info":[{"award-number":["KMUH114\u20104R25"]}],"id":[{"id":"10.13039\/501100011645","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Int J of Rheum Dis"],"published-print":{"date-parts":[[2026,8]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Objectives<\/jats:title>\n                    <jats:p>Chikungunya virus (CHIKV) infection might cause chronic chikungunya arthritis resembling rheumatoid arthritis (RA). The purpose of this study is to investigate the potential role of this virus in the pathogenesis of RA in Taiwan, a non\u2010endemic area.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>This cross\u2010sectional study enrolled 98 RA patients and 200 healthy controls. Serum CHIKV IgM and IgG were tested using two commercial enzyme\u2010linked immunosorbent assay (ELISA) kits (Abcam and Euroimmun) and an in\u2010house neutralization assay. ELISA\u2010IgM was performed only in patients with RA. ELISA or neutralization positive samples were further tested for CHIKV RNA by reverse\u2010transcription\u2010polymerase chain reaction. Associations between CHIKV seropositivity and various autoantibodies were analyzed. The agreements among these assays were also evaluated.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Neutralizing antibodies were detected in 2 of 98 RA patients and in none of the controls (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.107, Fisher's exact test;\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.043, chi\u2010square). Both patients were absent from Abcam\u2010IgM and \u2010IgG, as well as Euroimmun\u2010IgM and \u2010IgG testing. There was no association between Abcam\u2010IgM or Euroimmun\u2010IgM and rheumatoid factor, anti\u2010cyclic citrullinated peptide, antinuclear, or anti\u2010extractable nuclear antigen antibodies. Poor agreements were noted between the neutralizing assay and Abcam\u2010IgG or Euroimmun\u2010IgG (\n                      <jats:italic>\u03ba<\/jats:italic>\n                      \u2009=\u20090 and 0, respectively). A similar finding was also found between Abcam\u2010IgM and Euroimmun\u2010IgM (\n                      <jats:italic>\u03ba<\/jats:italic>\n                      \u2009=\u2009\u22120.38).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Our study was not sufficiently powered to establish a causal association between CHIKV infection and RA development. Poor agreements were noted among different commercial ELISA kits and neutralization assays, underscoring the limitations of the serology assay.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/1756-185x.70784","type":"journal-article","created":{"date-parts":[[2026,8,5]],"date-time":"2026-08-05T08:24:01Z","timestamp":1785918241000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Association Between Chikungunya Infection and Rheumatoid Arthritis in Taiwan\u2014A Cross\u2010Sectional Study"],"prefix":"10.1111","volume":"29","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7998-6420","authenticated-orcid":false,"given":"Chang\u2010Yi","family":"Yen","sequence":"first","affiliation":[{"name":"Division of Allergy, Immunology and Rheumatology, Department of Internal Medicine Kaohsiung Medical University Hospital  Kaohsiung Taiwan"},{"name":"Institute of Medical Informatics, College of Electrical Engineering and Computer Science National Cheng Kung University  Tainan Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chang\u2010Chi","family":"Lin","sequence":"additional","affiliation":[{"name":"Institute of Preventive Medicine National Defense Medical Center  Taipei Taiwan"},{"name":"Department and Graduate Institute of Microbiology and Immunology National Defense Medical Center  Taipei Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ping\u2010Chang","family":"Lin","sequence":"additional","affiliation":[{"name":"Tropical Medicine Center, Kaohsiung Medical University Hospital  Kaohsiung Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ching\u2010Yi","family":"Tsai","sequence":"additional","affiliation":[{"name":"Tropical Medicine Center, Kaohsiung Medical University Hospital  Kaohsiung Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7993-7263","authenticated-orcid":false,"given":"Li\u2010Teh","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Medical Laboratory Science and Biotechnology College of Medical Technology, Chung\u2010Hwa University of Medical Technology  Tainan City Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0005-1656-7188","authenticated-orcid":false,"given":"Chen\u2010Hsuan","family":"Lin","sequence":"additional","affiliation":[{"name":"School of Medicine, College of Medicine, Kaohsiung Medical University  Kaohsiung Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3028-5508","authenticated-orcid":false,"given":"Chun\u2010Hong","family":"Chen","sequence":"additional","affiliation":[{"name":"National Mosquito\u2010Borne Diseases Control Research Center National Health 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