{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,24]],"date-time":"2026-08-24T11:19:31Z","timestamp":1787570371167,"version":"build-2736575974"},"reference-count":21,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2026,8,5]],"date-time":"2026-08-05T00:00:00Z","timestamp":1785888000000},"content-version":"vor","delay-in-days":4,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,8,1]],"date-time":"2026-08-01T00:00:00Z","timestamp":1785542400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100018542","name":"Natural Science Foundation of Sichuan Province","doi-asserted-by":"publisher","award":["2024NSFSC0615"],"award-info":[{"award-number":["2024NSFSC0615"]}],"id":[{"id":"10.13039\/501100018542","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Int J of Rheum Dis"],"published-print":{"date-parts":[[2026,8]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Objectives<\/jats:title>\n                    <jats:p>BTN3A1 has been associated with systemic lupus erythematosus (SLE) and psoriasis; however, its relationship with rheumatoid arthritis (RA) risk, particularly regarding BTN3A1 polymorphisms and RA susceptibility remains unclear.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>A total of 390 age\u2010 and sex\u2010matched participants, including RA patients and healthy controls, were enrolled. Demographic, laboratory, and clinical data were collected. Five BTN3A1 polymorphisms (rs1796520, rs3857550, rs3208733, rs6912853, rs10456045) were genotyped. Allele and genotype associations between the groups were analyzed, as well as their associations with clinical and laboratory features in RA patients.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Among RA patients, 79.74% were female and 20.26% were male; among controls, 84.36% were female and 15.64% were male. For rs3208733, the frequencies of the CC genotype and C allele differed significantly between RA patients and controls. For rs6912853, the frequency of the TC genotype differed significantly. For rs10456045, the frequencies of the GG, AG, and GG\u2009+\u2009AG genotypes differed significantly. Regarding clinical and laboratory associations: for rs1796520, antinuclear antibody (ANA)\u2010positive patients showed higher frequencies of the CC\u2009+\u2009TC genotype and C allele; anti\u2010Rib\u2010positive patients showed a higher frequency of the C allele. RA patients carrying the CC\u2009+\u2009TC genotype had fewer swollen joints and higher levels of IL\u201012p70 and IFN\u2010\u03b1 than TT carriers. For rs6912853, CC\u2009+\u2009TC carriers had fewer tender joints and higher levels of C\u2010reactive protein (CRP) and IFN\u2010\u03b3 than TT carriers.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>BTN3A1 gene polymorphisms are associated with RA risk, suggesting future therapeutic exploration of BTN3A1 in RA.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/1756-185x.70792","type":"journal-article","created":{"date-parts":[[2026,8,5]],"date-time":"2026-08-05T08:28:49Z","timestamp":1785918529000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Genetic Association Between\n                    <scp>BTN3A1<\/scp>\n                    Polymorphisms and the Risk of Rheumatoid Arthritis in a Chinese Population"],"prefix":"10.1111","volume":"29","author":[{"given":"Qingxue","family":"Shu","sequence":"first","affiliation":[{"name":"Department of Rheumatology and Immunology The Affiliated Hospital, Southwest Medical University  Luzhou Sichuan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3860-8383","authenticated-orcid":false,"given":"Anfang","family":"Huang","sequence":"additional","affiliation":[{"name":"Department of Rheumatology and Immunology The Affiliated Hospital, Southwest Medical University  Luzhou Sichuan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0004-9843-1454","authenticated-orcid":false,"given":"Chengsong","family":"He","sequence":"additional","affiliation":[{"name":"Department of Rheumatology and Immunology The Affiliated Hospital, Southwest Medical University  Luzhou Sichuan 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