{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,24]],"date-time":"2026-08-24T11:19:23Z","timestamp":1787570363135,"version":"build-2736575974"},"reference-count":43,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2026,8,10]],"date-time":"2026-08-10T00:00:00Z","timestamp":1786320000000},"content-version":"vor","delay-in-days":9,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,8,1]],"date-time":"2026-08-01T00:00:00Z","timestamp":1785542400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Int J of Rheum Dis"],"published-print":{"date-parts":[[2026,8]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>Rheumatoid arthritis\u2013associated interstitial lung disease (RA\u2010ILD) is a major extra\u2010articular complication contributing to increased morbidity and mortality. Circulating microRNAs (miRNAs) have emerged as potential non\u2010invasive biomarkers in autoimmune diseases. This study aimed to evaluate whether plasma miRNA\u20107\u20105p and miRNA\u2010214\u20105p are associated with the presence of RA\u2010ILD and with radiological and functional indicators of pulmonary involvement.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>In this cross\u2010sectional study, 58 RA patients (29 RA\u2010ILD, 29 without ILD) and 30 matched healthy controls were included. RA\u2010ILD was diagnosed by multidisciplinary assessment (HRCT and pulmonary function tests). Plasma miRNA levels were measured by qRT\u2010PCR and analyzed using the 2^\u2212\u0394\u0394CT method. Diagnostic performance was evaluated by ROC analysis.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Plasma miRNA\u20107\u20105p and miRNA\u2010214\u20105p levels were significantly higher in RA patients compared with healthy controls (\n                      <jats:italic>p<\/jats:italic>\n                      &lt;\u20090.05 for both). Among RA patients, both miRNAs were significantly lower in those with ILD (\n                      <jats:italic>p<\/jats:italic>\n                      &lt;\u20090.05). miRNA\u20107\u20105p demonstrated promising discriminatory performance for identifying RA\u2010ILD (AUC\u2009=\u20090.87, 95% CI: 0.760\u20130.947;\n                      <jats:italic>p<\/jats:italic>\n                      &lt;\u20090.001), whereas miRNA\u2010214\u20105p showed modest accuracy (AUC\u2009=\u20090.676, 95% CI: 0.539\u20130.794;\n                      <jats:italic>p<\/jats:italic>\n                      =\u20090.01). In multivariable analysis, ILD presence was independently associated with decreased levels of both miRNAs. Neither miRNA correlated significantly with DAS28\u2010CRP, disease duration, nor with radiological or functional severity parameters.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Circulating miRNA\u20107\u20105p and miRNA\u2010214\u20105p are associated with the presence of RA\u2010ILD but do not reflect disease severity in this cohort. Larger prospective studies are required to validate their potential role as adjunctive biomarkers for RA\u2010ILD detection and risk stratification.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/1756-185x.70820","type":"journal-article","created":{"date-parts":[[2026,8,10]],"date-time":"2026-08-10T08:16:07Z","timestamp":1786349767000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Association of Plasma\n                    <scp>miRNA<\/scp>\n                    \u20107\u20105p and\n                    <scp>miRNA<\/scp>\n                    \u2010214\u20105p With Rheumatoid Arthritis Associated Interstitial Lung Disease"],"prefix":"10.1111","volume":"29","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4871-6035","authenticated-orcid":false,"given":"Irem","family":"Sahino\u011flu","sequence":"first","affiliation":[{"name":"Division of Rheumatology, Department of Internal Medicine Manisa Celal Bayar 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Medicine  Manisa Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0009-0419","authenticated-orcid":false,"given":"Emre Ali","family":"Acar","sequence":"additional","affiliation":[{"name":"Division of Rheumatology, Department of Internal Medicine Manisa Celal Bayar University School of Medicine  Manisa Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4022-133X","authenticated-orcid":false,"given":"Filiz Cemre","family":"Tasg\u00f6z","sequence":"additional","affiliation":[{"name":"Division of Rheumatology, Department of Internal Medicine Manisa Celal Bayar University School of Medicine  Manisa Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0003-2709-414X","authenticated-orcid":false,"given":"Mevl\u00fct","family":"Kacar","sequence":"additional","affiliation":[{"name":"Division of Rheumatology, Department of Internal Medicine Manisa 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