{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,24]],"date-time":"2026-08-24T11:19:32Z","timestamp":1787570372368,"version":"build-2736575974"},"reference-count":36,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2026,8,17]],"date-time":"2026-08-17T00:00:00Z","timestamp":1786924800000},"content-version":"vor","delay-in-days":16,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,8,1]],"date-time":"2026-08-01T00:00:00Z","timestamp":1785542400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Int J of Rheum Dis"],"published-print":{"date-parts":[[2026,8]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Objectives<\/jats:title>\n                    <jats:p>Beh\u00e7et's disease (BD) is a chronic, multisystem immune\u2010mediated vasculitis. A significant number of patients with BD have inflammatory comorbid (IC) disease that can affect the clinical course of the disease. In the current literature, there is no study which investigated IC disease in BD. It was aimed to show the prevalence and clinical spectrum of IC disease in patients with BD.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>A total of 1591 patients diagnosed with BD and followed at five tertiary healthcare facilities were enrolled in the study. Patients were divided according to the presence of IC disease. Demographic characteristics, clinical manifestations, and laboratory parameters were systematically noted from medical records. The activity of the disease was evaluated by Beh\u00e7et's Disease Current Activity Form (BDCAF).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Inflammatory comorbid diseases were identified in 246 (15.3%) patients. The most common comorbidities were axial spondyloarthritis (\n                      <jats:italic>n<\/jats:italic>\n                      \u2009=\u2009115, 7.2%), familial Mediterranean fever (FMF) (\n                      <jats:italic>n<\/jats:italic>\n                      \u2009=\u200938, 2.4%), and hidradenitis suppurativa (\n                      <jats:italic>n<\/jats:italic>\n                      \u2009=\u200937, 2.3%). Patients with IC disease had a greater use of anti\u2010TNF treatment (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.03). In the multivariate analysis, older age, and longer disease duration were found to be significantly associated with IC disease in BD (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.05).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>BD can be associated with other inflammatory conditions. Furthermore, patients with inflammatory comorbidities were more likely to receive anti\u2010TNF therapy, although this may partly reflect treatment indications for the comorbid conditions themselves. Therefore, clinicians should remain vigilant for inflammatory comorbidities, as their recognition may have implications for therapeutic decision\u2010making.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/1756-185x.70826","type":"journal-article","created":{"date-parts":[[2026,8,17]],"date-time":"2026-08-17T12:30:13Z","timestamp":1786969813000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Comorbid Inflammatory Diseases in Beh\u00e7et's Disease: A Multicenter Large Cohort Study"],"prefix":"10.1111","volume":"29","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9749-5585","authenticated-orcid":false,"given":"Emine B\u00fc\u015fra","family":"Ata","sequence":"first","affiliation":[{"name":"Department of Internal Medicine, Division of Rheumatology University of Health Sciences, Gulhane Training and Research Hospital  Ankara Turkiye"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0790-9519","authenticated-orcid":false,"given":"\u0130brahim Yahya","family":"\u00c7ak\u0131r","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, Division of Rheumatology Gazi University Faculty of Medicine  Ankara Turkiye"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Semiha","family":"K\u00f6ro\u011flu","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, Division of Rheumatology Ege University Faculty of Medicine  \u0130zmir Turkiye"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1908-8439","authenticated-orcid":false,"given":"G\u00fclay","family":"Alp","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, Division of Rheumatology U\u015fak University Faculty of Medicine  U\u015fak Turkiye"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4690-610X","authenticated-orcid":false,"given":"Mete","family":"Kara","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, Division of Rheumatology University of Health Sciences, \u0130zmir City Hospital  \u0130zmir Turkiye"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2493-2465","authenticated-orcid":false,"given":"Ebru","family":"Kara\u00e7al\u0131","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, Division of Rheumatology University of Health Sciences, Gulhane Training and Research Hospital  Ankara Turkiye"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fatih Mehmet","family":"Do\u011fan","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, Division of Rheumatology University of Health Sciences, Gulhane Training and Research 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