{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,24]],"date-time":"2026-08-24T11:19:33Z","timestamp":1787570373645,"version":"build-2736575974"},"reference-count":32,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2026,8,12]],"date-time":"2026-08-12T00:00:00Z","timestamp":1786492800000},"content-version":"vor","delay-in-days":11,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,8,1]],"date-time":"2026-08-01T00:00:00Z","timestamp":1785542400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Int J of Rheum Dis"],"published-print":{"date-parts":[[2026,8]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Introduction<\/jats:title>\n                    <jats:p>Knee osteoarthritis (OA) causes chronic pain and disability, with limited benefit from conventional treatments. Platelet\u2010rich plasma (PRP) has been proposed as a biologic therapy with potential tissue\u2010repair properties; however, its clinical efficacy remains uncertain.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>To assess the effectiveness of intra\u2010articular PRP injections in reducing pain and improving function in patients with knee OA.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methodology<\/jats:title>\n                    <jats:p>This systematic review and meta\u2010analysis included randomized controlled trials comparing intra\u2010articular PRP with placebo or no treatment. Pain outcomes were measured using the Visual Analog Scale (VAS), while functional outcomes were assessed using the Western Ontario and McMaster Universities Osteoarthritis Index (WOMAC) or Knee injury and Osteoarthritis Outcome Score (KOOS).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>PRP significantly reduced pain and improved function compared with placebo across short\u2010, mid\u2010, and long\u2010term follow\u2010up. The magnitude of benefit varied but remained clinically relevant.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>PRP provides significant improvements in pain relief and functional outcomes compared with placebo or no treatment in patients with knee OA, supporting its potential as a therapeutic option. Standardized protocols and larger RCTs are warranted to further confirm its clinical effectiveness.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/1756-185x.70827","type":"journal-article","created":{"date-parts":[[2026,8,13]],"date-time":"2026-08-13T06:16:59Z","timestamp":1786601819000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Effectiveness of Platelet\u2010Rich Plasma in Knee Osteoarthritis: A Systematic Review and Meta\u2010Analysis"],"prefix":"10.1111","volume":"29","author":[{"ORCID":"https:\/\/orcid.org\/0009-0006-6866-0410","authenticated-orcid":false,"given":"Hsuan\u2010Wei","family":"Liu","sequence":"first","affiliation":[{"name":"Department of Public Health China Medical University  Taichung Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,8,12]]},"reference":[{"key":"e_1_2_13_2_1","doi-asserted-by":"publisher","DOI":"10.5312\/wjo.v5.i3.351"},{"key":"e_1_2_13_3_1","doi-asserted-by":"publisher","DOI":"10.1097\/PR9.0000000000001017"},{"key":"e_1_2_13_4_1","volume-title":"StatPearls","author":"Hsu H.","year":"2024"},{"key":"e_1_2_13_5_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12178-018-9527-7"},{"key":"e_1_2_13_6_1","doi-asserted-by":"publisher","DOI":"10.2147\/JPR.S154002"},{"key":"e_1_2_13_7_1","doi-asserted-by":"publisher","DOI":"10.3389\/fphar.2021.661805"},{"key":"e_1_2_13_8_1","doi-asserted-by":"publisher","DOI":"10.3390\/jfmk6010015"},{"key":"e_1_2_13_9_1","unstructured":"American Physical Therapy Association Western Ontario and McMaster Universities Osteoarthritis Index (WOMAC)n.d. https:\/\/www.apta.org\/patient\u2010care\/evidence\u2010based\u2010practice\u2010resources\/test\u2010measures\/womac."},{"key":"e_1_2_13_10_1","unstructured":"WOMAC\u2010AUSCAN Osteoarthritis Global Indexn.d. https:\/\/womac.com\/womac\/index.php."},{"key":"e_1_2_13_11_1","doi-asserted-by":"publisher","DOI":"10.46658\/JBIMES-24-01"},{"key":"e_1_2_13_12_1","volume-title":"Comparative Effectiveness Review Methods: Clinical and Statistical Issues","author":"West S. 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