{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,24]],"date-time":"2026-08-24T11:19:23Z","timestamp":1787570363064,"version":"build-2736575974"},"reference-count":38,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2026,8,21]],"date-time":"2026-08-21T00:00:00Z","timestamp":1787270400000},"content-version":"vor","delay-in-days":20,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,8,1]],"date-time":"2026-08-01T00:00:00Z","timestamp":1785542400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100000646","name":"Japan Society for the Promotion of Science London","doi-asserted-by":"publisher","award":["JP20K11597"],"award-info":[{"award-number":["JP20K11597"]}],"id":[{"id":"10.13039\/501100000646","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Int J of Rheum Dis"],"published-print":{"date-parts":[[2026,8]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Aim<\/jats:title>\n                    <jats:p>Diet may influence the clinical course of rheumatoid arthritis (RA). Consumption of fish, the main source of n\u20103 polyunsaturated fatty acids (PUFAs), has been linked to decreased disease activity. We investigated the association between fish intake and disease activity in two different cohorts of RA patients receiving molecular\u2010targeted therapies.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>This retrospective cross\u2010sectional study included RA patients treated with biologics or Janus kinase inhibitors at Hokkaido University Hospital (Japan) and Virgen de las Nieves Hospital (Spain). Patients completed the validated brief\u2010type self\u2010administered diet history questionnaire (BDHQ, used with permission) and a custom\u2010designed detailed fish frequency questionnaire (DFFQ). Demographic, clinical, and laboratory data were obtained from medical records. Minimal disease activity (MDA) was defined as DAS28\u2010ESR &lt;\u20092.6 and DAS28\u2010CRP &lt;\u20092.4. Group comparisons and multivariate logistic regression analyses were performed.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>In the Japanese cohort of 205 RA patients, 59% of patients met MDA criteria. Patients with MDA had a higher estimated daily intake of n\u20103 PUFAs than those with non\u2010MDA. Multivariate logistic regression analysis identified weekly intake of n\u20103 PUFA\u2010rich fish as an independent factor associated with MDA. In the Spanish RA cohort of 74 patients, 37% met MDA criteria. No significant differences in n\u20103 PUFA intake or fish consumption were observed between MDA and non\u2010MDA groups.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Consumption of n\u20103 PUFA\u2010rich fish was associated with MDA in patients with RA receiving molecular\u2010targeted therapies.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/1756-185x.70834","type":"journal-article","created":{"date-parts":[[2026,8,21]],"date-time":"2026-08-21T23:50:48Z","timestamp":1787356248000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Association Between Fish Consumption and Minimal Disease Activity in Patients With Rheumatoid Arthritis Receiving Molecular\u2010Targeted Therapies"],"prefix":"10.1111","volume":"29","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9524-3608","authenticated-orcid":false,"given":"Masato","family":"Tarumi","sequence":"first","affiliation":[{"name":"Department of Rheumatology, Endocrinology and Nephrology, Faculty of Medicine and Graduate School of Medicine Hokkaido University  Sapporo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Olga","family":"Amengual","sequence":"additional","affiliation":[{"name":"Department of Rheumatology, Endocrinology and Nephrology, Faculty of Medicine and Graduate School of Medicine Hokkaido University  Sapporo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M\u00edriam","family":"Navidad","sequence":"additional","affiliation":[{"name":"Department of Rheumatology Hospital Virgen de las Nieves  Granada Spain"},{"name":"Department of Rheumatology Hospital Torrec\u00e1rdenas  Almer\u00eda 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Hokkaido University  Sapporo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8601-6377","authenticated-orcid":false,"given":"Kuniyuki","family":"Aso","sequence":"additional","affiliation":[{"name":"Department of Rheumatology, Endocrinology and Nephrology, Faculty of Medicine and Graduate School of Medicine Hokkaido University  Sapporo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4225-1639","authenticated-orcid":false,"given":"Ryo","family":"Hisada","sequence":"additional","affiliation":[{"name":"Department of Rheumatology, Endocrinology and Nephrology, Faculty of Medicine and Graduate School of Medicine Hokkaido University  Sapporo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2149-7573","authenticated-orcid":false,"given":"Hiroyuki","family":"Nakamura","sequence":"additional","affiliation":[{"name":"Department of 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