{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,23]],"date-time":"2026-09-23T08:00:54Z","timestamp":1790150454676,"version":"4.0.1"},"reference-count":30,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2026,9,22]],"date-time":"2026-09-22T00:00:00Z","timestamp":1790035200000},"content-version":"vor","delay-in-days":21,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T00:00:00Z","timestamp":1788220800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100004586","name":"Funda\u00e7\u00e3o Carlos Chagas Filho de Amparo \u00e0 Pesquisa do Estado do Rio de Janeiro","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100004586","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002322","name":"Coordena\u00e7\u00e3o de Aperfei\u00e7oamento de Pessoal de N\u00edvel Superior","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100002322","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100006506","name":"Minist\u00e9rio da Sa\u00fade","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100006506","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Int J of Rheum Dis"],"published-print":{"date-parts":[[2026,9]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Objectives<\/jats:title>\n                    <jats:p>This cross\u2010sectional study investigated the occurrence of neuropathic pain features (NP) in individuals with end\u2010stage knee osteoarthritis (KOA) referred to total knee arthroplasty (TKA) and explored its association with functional and quality\u2010of\u2010life outcomes.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      In 902 patients, NP was screened using the Douleur Neuropathique 4 (scores \u2265\u20094). Distribution of NP features (positive\/negative) regarding sex were assessed with\n                      <jats:italic>z<\/jats:italic>\n                      \u2010test for proportions. The influence of NP features on the outcomes (visual analog scale for pain, WOMAC, SF\u201036) were tested with the Mann\u2013Whitney\n                      <jats:italic>U<\/jats:italic>\n                      , followed by a multivariate logistic regression model to identify independent predictors of NP features, using 5% as statistical threshold.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      The cohort was 72.6% female, with a mean\u2009\u00b1\u2009SD\u00a0age of 70\u2009\u00b1\u20098\u2009years. NP\u2010positive features prevalence was 28.6% (95% CI of 25.7%\u201331.6%), which was significantly higher in females (31.5%) than males (21.1%;\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.001). Patients with NP\u2010positive features reported worse scores across all measured domains: higher pain intensity (VAS;\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.001), worse knee\u2010related symptoms\/function (WOMAC pain, function, and total scores; all\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.001), and lower quality\u2010of\u2010life in specific SF\u201036 domains (general health, vitality, role\u2010emotional, mental health; all\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.01). The multivariate model confirmed that higher WOMAC total score and specific SF\u201036 scores were independently associated with NP\u2010positive features.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>NP features are prevalent in approximately one\u2010third of the patients with end\u2010stage KOA awaiting arthroplasty, particularly among females. Its presence is independently associated with poorer joint\u2010related function and reduced quality\u2010of\u2010life, suggesting the potential value of NP features assessment and management into pre\u2010 and postsurgical care.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/1756-185x.70882","type":"journal-article","created":{"date-parts":[[2026,9,22]],"date-time":"2026-09-22T13:07:23Z","timestamp":1790082443000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["<scp>DN4<\/scp>\n                    \u2010Positive Neuropathic Pain Features in End\u2010Stage Knee Osteoarthritis Awaiting Arthroplasty: Prevalence and Relationship With Function and Quality\u2010of\u2010Life"],"prefix":"10.1111","volume":"29","author":[{"given":"Alan P.","family":"Mozella","sequence":"first","affiliation":[{"name":"Centro de Cirurgia Do Joelho Instituto Nacional de Traumatologia e Ortopedia \u2013 INTO  Rio de Janeiro Brazil"},{"name":"Faculdade de Ci\u00eancias M\u00e9dicas Universidade do Estado do Rio de Janeiro \u2013 UERJ  Rio de Janeiro Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2556-3446","authenticated-orcid":false,"given":"Ana Carolina","family":"Leal","sequence":"additional","affiliation":[{"name":"Divis\u00e3o de Ensino e Pesquisa Instituto Nacional de Traumatologia e Ortopedia \u2013 INTO  Rio de Janeiro Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2112-7652","authenticated-orcid":false,"given":"Rafael Erthal","family":"de Paula","sequence":"additional","affiliation":[{"name":"Centro de Cirurgia Do Joelho Instituto Nacional de Traumatologia e Ortopedia \u2013 INTO  Rio de Janeiro Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3762-0890","authenticated-orcid":false,"given":"Aline Cordeiro Fernandes","family":"Ladeira","sequence":"additional","affiliation":[{"name":"Divis\u00e3o de Ensino e Pesquisa Instituto Nacional de Traumatologia e Ortopedia \u2013 INTO  Rio de Janeiro Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8815-2161","authenticated-orcid":false,"given":"Sandra","family":"Minamoto","sequence":"additional","affiliation":[{"name":"Centro de Cirurgia Do Joelho Instituto Nacional de Traumatologia e Ortopedia \u2013 INTO  Rio de Janeiro Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Matheus","family":"Carvalho","sequence":"additional","affiliation":[{"name":"Divis\u00e3o de Ensino e Pesquisa Instituto Nacional de Traumatologia e Ortopedia \u2013 INTO  Rio de Janeiro Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jordanna Franco","family":"Sucupira","sequence":"additional","affiliation":[{"name":"Divis\u00e3o de Ensino e Pesquisa Instituto Nacional de Traumatologia e Ortopedia \u2013 INTO  Rio de Janeiro Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0002-4539-6435","authenticated-orcid":false,"given":"Ricardo","family":"Kobayashi","sequence":"additional","affiliation":[{"name":"Centro de Dor Universidade de S\u00e3o Paulo \u2013 USP  S\u00e3o Paulo Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6657-5689","authenticated-orcid":false,"given":"Thiago","family":"Lemos","sequence":"additional","affiliation":[{"name":"Divis\u00e3o de Ensino e Pesquisa Instituto Nacional de Traumatologia e Ortopedia \u2013 INTO  Rio de Janeiro Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,9,22]]},"reference":[{"key":"e_1_2_13_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.joca.2013.03.018"},{"key":"e_1_2_13_3_1","doi-asserted-by":"publisher","DOI":"10.1186\/s42358\u2010021\u201000225\u20100"},{"key":"e_1_2_13_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/papr.12220"},{"key":"e_1_2_13_5_1","doi-asserted-by":"publisher","DOI":"10.1152\/physrev.00045.2019"},{"key":"e_1_2_13_6_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41572\u2010023\u201000484\u20109"},{"key":"e_1_2_13_7_1","doi-asserted-by":"publisher","DOI":"10.1097\/00002508\u2010200211000\u201000001"},{"key":"e_1_2_13_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.kjms.2016.12.007"},{"key":"e_1_2_13_9_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0199165"},{"key":"e_1_2_13_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.semarthrit.2017.02.008"},{"key":"e_1_2_13_11_1","doi-asserted-by":"publisher","DOI":"10.21608\/mjmr.2022.221406"},{"key":"e_1_2_13_12_1","doi-asserted-by":"publisher","DOI":"10.1097\/AJP.0000000000000504"},{"key":"e_1_2_13_13_1","doi-asserted-by":"publisher","DOI":"10.31609\/jpmrs.2019\u201070004"},{"key":"e_1_2_13_14_1","doi-asserted-by":"publisher","DOI":"10.1055\/s\u20100043\u20101776986"},{"key":"e_1_2_13_15_1","doi-asserted-by":"publisher","DOI":"10.1111\/os.13491"},{"key":"e_1_2_13_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.joca.2018.01.002"},{"key":"e_1_2_13_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.semarthrit.2014.05.011"},{"key":"e_1_2_13_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.pain.2004.12.010"},{"key":"e_1_2_13_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpain.2009.09.014"},{"key":"e_1_2_13_20_1","doi-asserted-by":"publisher","DOI":"10.5812\/amh\u2010154462"},{"key":"e_1_2_13_21_1","doi-asserted-by":"publisher","DOI":"10.52312\/jdrs.2025.1979"},{"key":"e_1_2_13_22_1","doi-asserted-by":"publisher","DOI":"10.1136\/ard.56.8.493"},{"key":"e_1_2_13_23_1","doi-asserted-by":"publisher","DOI":"10.1590\/S1413\u201078522012000100005"},{"key":"e_1_2_13_24_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12891\u2010023\u201006696\u20100"},{"issue":"3","key":"e_1_2_13_25_1","first-page":"143","article-title":"Brazilian\u2010Portuguese Version of the SF\u201036 Questionnaire: A Reliable and Valid Quality of Life Outcome Measure","volume":"39","author":"Ciconelli R.","year":"1999","journal-title":"Revista Brasileira de Reumatologia"},{"key":"e_1_2_13_26_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.joca.2021.03.021"},{"key":"e_1_2_13_27_1","doi-asserted-by":"publisher","DOI":"10.1155\/2020\/7408508"},{"key":"e_1_2_13_28_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00167\u2010013\u20102409\u2010z"},{"key":"e_1_2_13_29_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10072\u2010017\u20103092\u20105"},{"key":"e_1_2_13_30_1","doi-asserted-by":"publisher","DOI":"10.1212\/01.wnl.0000259085.61898.9e"},{"key":"e_1_2_13_31_1","doi-asserted-by":"publisher","DOI":"10.1155\/prm\/6417337"}],"container-title":["International Journal of Rheumatic Diseases"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/1756-185x.70882","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/1756-185x.70882","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/1756-185x.70882","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,9,23]],"date-time":"2026-09-23T07:05:39Z","timestamp":1790147139000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/1756-185x.70882"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,9]]},"references-count":30,"journal-issue":{"issue":"9","published-print":{"date-parts":[[2026,9]]}},"alternative-id":["10.1111\/1756-185x.70882"],"URL":"https:\/\/doi.org\/10.1111\/1756-185x.70882","archive":["Portico"],"relation":{},"ISSN":["1756-1841","1756-185X"],"issn-type":[{"value":"1756-1841","type":"print"},{"value":"1756-185X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,9]]},"assertion":[{"value":"2026-06-11","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-09-14","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-09-22","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e70882"}}