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Here, we investigated the impact of\n                    <jats:styled-content style=\"fixed-case\">HCN<\/jats:styled-content>\n                    as a signal in cell\u2010cell communication by comparing the transcriptome of the wild\u2010type strain\n                    <jats:styled-content style=\"fixed-case\">PAO<\/jats:styled-content>\n                    1 to that of an\n                    <jats:styled-content style=\"fixed-case\">HCN<\/jats:styled-content>\n                    \u2010negative mutant under cyanogenic conditions.\n                    <jats:styled-content style=\"fixed-case\">HCN<\/jats:styled-content>\n                    repressed four genes and induced 12 genes. While the individual functions of these genes are unknown, with one exception (i.e. a ferredoxin\u2010dependent reductase), a highly inducible six\u2010gene cluster (\n                    <jats:styled-content style=\"fixed-case\">PA<\/jats:styled-content>\n                    4129\u2010\n                    <jats:styled-content style=\"fixed-case\">PA<\/jats:styled-content>\n                    4134) was found to be crucial for protection of\n                    <jats:italic>\n                      <jats:styled-content style=\"fixed-case\">P<\/jats:styled-content>\n                      .\u2009aeruginosa\n                    <\/jats:italic>\n                    from external\n                    <jats:styled-content style=\"fixed-case\">HCN<\/jats:styled-content>\n                    intoxication. A double mutant deleted for\n                    <jats:styled-content style=\"fixed-case\">PA<\/jats:styled-content>\n                    4129\u2010\n                    <jats:styled-content style=\"fixed-case\">PA<\/jats:styled-content>\n                    4134 and\n                    <jats:styled-content style=\"fixed-case\">\n                      <jats:italic>cioAB<\/jats:italic>\n                    <\/jats:styled-content>\n                    (encoding cyanide\u2010insensitive oxidase) did not grow with 100\u2009\u03bc\n                    <jats:styled-content style=\"fixed-case\">M KCN<\/jats:styled-content>\n                    , whereas the corresponding single mutants were essentially unaffected, suggesting a synergistic action of the\n                    <jats:styled-content style=\"fixed-case\">PA<\/jats:styled-content>\n                    4129\u2010\n                    <jats:styled-content style=\"fixed-case\">PA<\/jats:styled-content>\n                    4134 gene products and cyanide\u2010insensitive oxidase.\n                  <\/jats:p>","DOI":"10.1111\/1758-2229.12105","type":"journal-article","created":{"date-parts":[[2013,10,11]],"date-time":"2013-10-11T17:57:00Z","timestamp":1381514220000},"page":"28-34","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":29,"title":["A novel cyanide\u2010inducible gene cluster helps protect\n                    <i>\n                      <scp>P<\/scp>\n                      seudomonas aeruginosa\n                    <\/i>\n                    from cyanide"],"prefix":"10.1111","volume":"6","author":[{"given":"Emanuela","family":"Frangipani","sequence":"first","affiliation":[{"name":"D\u00e9partement de Microbiologie Fondamentale Universit\u00e9 de Lausanne  CH\u20101015 Lausanne 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