{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T05:12:23Z","timestamp":1790745143514,"version":"4.1.0"},"reference-count":57,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2015,9,10]],"date-time":"2015-09-10T00:00:00Z","timestamp":1441843200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"French National Center for Scientific Research (CNRS)"},{"DOI":"10.13039\/100015872","name":"University of Lille","doi-asserted-by":"crossref","id":[{"id":"10.13039\/100015872","id-type":"DOI","asserted-by":"crossref"}]},{"name":"French Ministry of the Higher Education and Research"},{"name":"National Institute for Allergy and Infectious Diseases, National Institutes of Health"}],"content-domain":{"domain":["enviromicro-journals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Environ Microbiol Rep"],"published-print":{"date-parts":[[2015,10]]},"abstract":"Summary<\/jats:title>\n \n This review emphasizes the biological roles of the osmoregulated periplasmic glucans (\n OPGs<\/jats:styled-content>\n ). Osmoregulated periplasmic glucans occur in almost all\n \u03b1<\/jats:styled-content>\n \u2010,\n \u03b2<\/jats:styled-content>\n \u2010 and\n \u03b3<\/jats:styled-content>\n \u2010Proteobacteria. This polymer of glucose is required for full virulence. The roles of the\n OPGs<\/jats:styled-content>\n are complex and vary depending on the species. Here, we outline the four major roles of the\n OPGs<\/jats:styled-content>\n through four different pathogenic and one symbiotic bacterial models (\n \n D<\/jats:italic>\n <\/jats:styled-content>\n ickeya dadantii<\/jats:italic>\n ,\n \n S<\/jats:italic>\n <\/jats:styled-content>\n almonella enterica<\/jats:italic>\n ,\n \n P<\/jats:italic>\n <\/jats:styled-content>\n seudomonas aeruginosa<\/jats:italic>\n ,\n \n B<\/jats:italic>\n <\/jats:styled-content>\n rucella abortus<\/jats:italic>\n and\n \n S<\/jats:italic>\n <\/jats:styled-content>\n inorhizobium meliloti<\/jats:italic>\n ). When periplasmic, the\n OPGs<\/jats:styled-content>\n are a part of the signal transduction pathway and indirectly regulate genes involved in virulence. The\n OPGs<\/jats:styled-content>\n can also be secreted. When outside of the cell, they interact directly with antibiotics to protect the bacterial cell or interact with the host cell to facilitate the invasion process. When\n OPGs<\/jats:styled-content>\n are not found, as in the \u03b5\u2010Proteobacteria,\n OPG<\/jats:styled-content>\n \u2010like oligosaccharides are present. Their presence strengthens the evidence that\n OPGs<\/jats:styled-content>\n play an important role in virulence.\n <\/jats:p>","DOI":"10.1111\/1758-2229.12325","type":"journal-article","created":{"date-parts":[[2015,8,11]],"date-time":"2015-08-11T23:49:06Z","timestamp":1439336946000},"page":"690-697","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":53,"title":["New insights into the biological role of the osmoregulated periplasmic glucans in pathogenic and symbiotic bacteria"],"prefix":"10.1111","volume":"7","author":[{"given":"S\u00e9bastien","family":"Bontemps\u2010Gallo","sequence":"first","affiliation":[{"name":"Rocky Mountain Laboratories Laboratory of Zoonotic Pathogens National Institute of Allergy and Infectious Diseases National Institutes of Health Hamilton MT USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jean\u2010Marie","family":"Lacroix","sequence":"additional","affiliation":[{"name":"Structural and Functional Glycobiology Unit University of Lille Villeneuve d'Ascq France"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2015,9,10]]},"reference":[{"key":"e_1_2_4_2_1","doi-asserted-by":"publisher","DOI":"10.1038\/ni1202"},{"key":"e_1_2_4_3_1","doi-asserted-by":"publisher","DOI":"10.1128\/JB.06178-11"},{"key":"e_1_2_4_4_1","doi-asserted-by":"publisher","DOI":"10.1099\/mic.0.023747-0"},{"key":"e_1_2_4_5_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1574-6968.2000.tb09075.x"},{"key":"e_1_2_4_6_1","first-page":"325","volume-title":"The Periplasm","author":"Bohin J.P.","year":"2006"},{"key":"e_1_2_4_7_1","first-page":"371429","article-title":"Biosynthesis of osmoregulated periplasmic glucans in Escherichia coli: the phosphoethanolamine transferase is encoded by opgE","author":"Bontemps\u2010Gallo S.","year":"2013","journal-title":"Biomed Res Int"},{"key":"e_1_2_4_8_1","doi-asserted-by":"publisher","DOI":"10.1111\/1462-2920.12054"},{"key":"e_1_2_4_9_1","doi-asserted-by":"publisher","DOI":"10.1099\/mic.0.074484-0"},{"key":"e_1_2_4_10_1","unstructured":"Bouchart F.(2006)Impact des mutations OPG chezErwinia chrysanthemi: recherche de suppresseurs et analyse prot\u00e9omique des mutants impact of OPG mutations ofErwinia chrysanthemi. 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