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Here, a bacterium designated\n                    <jats:italic>Pseudoalteromonas<\/jats:italic>\n                    sp. MT33b possessing strong Cd resistance was isolated from the Mariana Trench sediments. Supplement of cysteine significantly increased bacterial Cd resistance and removal rate. Biofilm formation was demonstrated to play a positive role toward bacterial Cd resistance. Transcriptome analysis showed the supplement of cysteine effectively prevented Cd\n                    <jats:sup>2+<\/jats:sup>\n                    from entering bacterial cells, promoted saccharide metabolism and thereby facilitating energy production, which consists well with bacterial growth trend analysed under the same conditions. Notably, the expressions of many biofilm formation related genes including flagellar assembly, signal transduction, bacterial secretion and TonB\u2010dependent transfer system were significantly upregulated when facing Cd stress, indicating their important roles in determining bacterial biofilm formation and enhancing Cd resistance. Overall, this study indicates the formation of insoluble CdS precipitates and massive biofilm is the major strategy adopted by\n                    <jats:italic>Pseudoalteromonas<\/jats:italic>\n                    sp. MT33b to eliminate Cd stress. Our results provide a good model to investigate how heavy metals impact biofilm formation in the deep\u2010sea ecosystems, which may facilitate a deeper understanding of microbial environmental adaptability and better utilization of these microbes for bioremediation purposes in the future.\n                  <\/jats:p>","DOI":"10.1111\/1758-2229.12933","type":"journal-article","created":{"date-parts":[[2021,1,28]],"date-time":"2021-01-28T23:49:11Z","timestamp":1611877751000},"page":"325-336","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":29,"title":["Cadmium sulfide nanoparticle biomineralization and biofilm formation mediate cadmium resistance of the deep\u2010sea bacterium\n                    <i>Pseudoalteromonas<\/i>\n                    sp.\u2009MT33b"],"prefix":"10.1111","volume":"13","author":[{"given":"Ning","family":"Ma","sequence":"first","affiliation":[{"name":"CAS Key Laboratory of Experimental Marine Biology 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