{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,3]],"date-time":"2026-09-03T10:58:30Z","timestamp":1788433110081,"version":"build-2803163510"},"reference-count":66,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2021,8,30]],"date-time":"2021-08-30T00:00:00Z","timestamp":1630281600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["enviromicro-journals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Environ Microbiol Rep"],"published-print":{"date-parts":[[2022,6]]},"abstract":"<jats:title>Summary<\/jats:title>\n                  <jats:p>\n                    <jats:italic>Vibrio parahaemolyticus<\/jats:italic>\n                    is a marine bacterium and causes opportunistic gastroenteritis in humans. Clinical strains of\n                    <jats:italic>V. parahaemolyticus<\/jats:italic>\n                    contain haemolysin and type III secretion systems (T3SS) that define their pathotype. A growing number of strains isolated recently from the environment have acquired these virulence genes constituting a pool of potential pathogens. This study used comparative genomics to identify genetic factors that delineate environmental and clinical\n                    <jats:italic>V. parahaemolyticus<\/jats:italic>\n                    population and understand the similarities and differences between the T3SS2 phylotypes. The comparative analysis revealed the presence of a cluster of genes belonging to bacterial cellulose synthesis (\n                    <jats:italic>bcs<\/jats:italic>\n                    ) in isolates of environmental origin. This cluster, previously unreported in\n                    <jats:italic>V. parahaemolyticus<\/jats:italic>\n                    , exhibit significant similarity to that of\n                    <jats:italic>Aliivibrio fischeri<\/jats:italic>\n                    , and might dictate a potentially new mechanism of its environmental adaptation and persistence. The study also identified many genes predicted\n                    <jats:italic>in silico<\/jats:italic>\n                    to be T3SS effectors that are unique to T3SS2\u03b2 of\n                    <jats:italic>tdh<\/jats:italic>\n                    <jats:sup>\u2212<\/jats:sup>\n                    <jats:italic>trh<\/jats:italic>\n                    <jats:sup>+<\/jats:sup>\n                    and\n                    <jats:italic>tdh<\/jats:italic>\n                    <jats:sup>+<\/jats:sup>\n                    <jats:italic>trh<\/jats:italic>\n                    <jats:sup>+<\/jats:sup>\n                    pathotype and having no identifiable homologue in\n                    <jats:italic>tdh<\/jats:italic>\n                    <jats:sup>+<\/jats:sup>\n                    <jats:italic>trh<\/jats:italic>\n                    <jats:sup>\u2212<\/jats:sup>\n                    T3SS2\u03b1. Overall, these findings highlight the importance of understanding the genes and strategies\n                    <jats:italic>V. parahaemolyticus<\/jats:italic>\n                    utilize for the myriad interactions with its hosts, either marine invertebrates or humans.\n                  <\/jats:p>","DOI":"10.1111\/1758-2229.13000","type":"journal-article","created":{"date-parts":[[2021,8,30]],"date-time":"2021-08-30T18:40:02Z","timestamp":1630348802000},"page":"365-375","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":9,"title":["Genomic attributes differ between\n                    <scp>\n                      <i>Vibrio parahaemolyticus<\/i>\n                    <\/scp>\n                    environmental and clinical isolates including pathotypes"],"prefix":"10.1111","volume":"14","author":[{"given":"Divya","family":"Meparambu Prabhakaran","sequence":"first","affiliation":[{"name":"Cholera and Biofilm Research Lab 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