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The results demonstrated that cocaine esterase genes were widely distributed in 1142 global wastewater samples collected from 64 countries and linked to several bacterial species. In addition,\n                    <jats:italic>in silico<\/jats:italic>\n                    predictions indicated that carfentanil, 4F\u2010MDMB\u2010BINACA, 5F\u2010MDMB\u2010PICA, MDMB\u20104en\u2010PINACA and mitragynine might also undergo microbial hydrolysis, in a similar fashion of cocaine degradation by cocaine esterase. 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