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This microbiome continuum provides a mechanistic perspective for One Health by linking microbial cells with the movement of metabolites, genes, signalling molecules and ecological functions across environmental boundaries. Here, we critically examined the biological processes that maintain this continuity, including dispersal, horizontal gene transfer (HGT), metabolic exchange, environmental exposure and host\u2013microbe communication. We consider how climate change and anthropogenic disturbance reshape these interactions and influence antimicrobial resistance (AMR), non\u2010communicable disease, ecosystem function and pathogen emergence. We further evaluate how artificial intelligence (AI), including machine learning and deep learning, can integrate multi\u2010omics and longitudinal data, while emphasizing that predictive performance does not establish causality and that AI remains dependent on data quality, biological knowledge and experimental validation. Engineered microbiomes offer opportunities for targeted intervention, but ecological stability, biosafety, HGT and translational uncertainty remain important constraints. We propose a One Health Microbiome Intelligence Framework (OH\u2010MIF) as a conceptual architecture for cross\u2010domain integration, with emphasis on standardized data, causal validation, equitable participation and human oversight.<\/jats:p>","DOI":"10.1111\/1758-2229.70445","type":"journal-article","created":{"date-parts":[[2026,10,24]],"date-time":"2026-10-24T02:06:19Z","timestamp":1792807579000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Microbiome Continuum: Connecting Environmental, Host\u2010Associated and Engineered Microbiomes Through One Health and Artificial Intelligence"],"prefix":"10.1111","volume":"18","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0175-6881","authenticated-orcid":false,"given":"Mohammad Nazrul Islam","family":"Bhuiyan","sequence":"first","affiliation":[{"name":"BCSIR Chattogram Laboratories BCSIR  Chattogram Bangladesh"},{"name":"Institute of Food Science and Technology 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