{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,15]],"date-time":"2026-01-15T01:57:23Z","timestamp":1768442243688,"version":"3.49.0"},"reference-count":17,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2014,1,2]],"date-time":"2014-01-02T00:00:00Z","timestamp":1388620800000},"content-version":"vor","delay-in-days":1,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Thoracic Cancer"],"published-print":{"date-parts":[[2014,1]]},"abstract":"Abstract<\/jats:title>Primary extranodal natural killer\/T<\/jats:styled-content>\u2010 cell lymphoma, nasal type (NK\/TCL<\/jats:styled-content>) in the lung is extremely rare and associated with E<\/jats:styled-content>pstein\u2010B<\/jats:styled-content>arr virus (EBV<\/jats:styled-content>) infection. An 80\u2010year\u2010old male presented with hemoptysis, which had lasted three days. Physical examination revealed inspiratory crackles at the left lung base and massive splenomegaly. Chest radiograph shows a mass\u2010like lesion in the left lower lung but no active lesion six months earlier. Computed tomography demonstrated a soft tissue mass (size: 6.6 \u00d7 5.1\u2009cm) with increased ground\u2010glass opacities in the left lower lobe, several pulmonary nodules, and mediastinal lymphadenopathy. Transthoracic needle biopsy of the left\u2010lower\u2010lobe lung mass was performed. The pathology revealed atypical lymphoid cell infiltration, which is immunoreactive for cytoplasmic CD3<\/jats:styled-content>, CD30<\/jats:styled-content> and CD56<\/jats:styled-content>, but not reactive for CK<\/jats:styled-content> and CD20<\/jats:styled-content>. EBV<\/jats:styled-content>\u2010encoded RNA<\/jats:styled-content> (EBER<\/jats:styled-content>) was also detected in these atypical lymphoid cells. The serum EBV DNA<\/jats:styled-content> level was 7.03 \u00d7 106<\/jats:sup>\u2009copies\/mL and subtype 1 EBV<\/jats:styled-content> was identified. No evidence of lymphoma involvement was found in the extrathoracic site. Primary pulmonary lymphoma showing nasal\u2010type NK\/T<\/jats:styled-content>\u2010cell subtype was diagnosed. Chemotherapy with cyclophosphamide and prednisolone was initiated immediately but the patient deteriorated and died three weeks later. In conclusion, patients presenting with rapidly growing lung mass and massive splenomegaly raise the possibility of aggressive pulmonary lymphoma. Extranodal NK\/T<\/jats:styled-content>\u2010cell lymphoma with high baseline plasma EBV DNA<\/jats:styled-content> levels signifies poor prognosis. Identifying young high\u2010risk patients may have benefits for early aggressive and successful treatment.<\/jats:p>","DOI":"10.1111\/1759-7714.12021","type":"journal-article","created":{"date-parts":[[2012,12,21]],"date-time":"2012-12-21T19:30:02Z","timestamp":1356118202000},"page":"93-96","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":14,"title":["Primary extranodal NK\/T<\/scp>\u2010cell lymphoma of the lung: Mimicking bronchogenic carcinoma"],"prefix":"10.1111","volume":"5","author":[{"given":"Chia\u2010Hsin","family":"Liu","sequence":"first","affiliation":[{"name":"Division of Pulmonary and Critical Care Department of Internal Medicine Tri\u2010Service General Hospital National Defense Medical Center Taipei Taiwan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hong\u2010Hau","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Radiology Tri\u2010Service General Hospital National Defense Medical Center Taipei Taiwan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Cherng\u2010Lih","family":"Perng","sequence":"additional","affiliation":[{"name":"Division of Clinical Pathology Department of Pathology Tri\u2010Service General Hospital Taipei Taiwan"},{"name":"Graduate Institute of Pathology National Defense Medical Center Taipei Taiwan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chung\u2010Kan","family":"Peng","sequence":"additional","affiliation":[{"name":"Division of Pulmonary and Critical Care Department of Internal Medicine Tri\u2010Service General Hospital National Defense Medical Center Taipei Taiwan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chih\u2010Feng","family":"Chian","sequence":"additional","affiliation":[{"name":"Division of Pulmonary and Critical Care Department of Internal Medicine Tri\u2010Service General Hospital National Defense Medical Center Taipei Taiwan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chih\u2010Hao","family":"Shen","sequence":"additional","affiliation":[{"name":"Division of Pulmonary and Critical Care Department of Internal Medicine Tri\u2010Service General Hospital National Defense Medical Center Taipei Taiwan"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2014,1,2]]},"reference":[{"key":"e_1_2_5_2_1","doi-asserted-by":"publisher","DOI":"10.1183\/09031936.02.00404102"},{"key":"e_1_2_5_3_1","doi-asserted-by":"crossref","first-page":"140","DOI":"10.1093\/oxfordjournals.jjco.a039766","article-title":"Primary pulmonary lymphoma: relationship between clinical features and pathologic findings in 24 cases. 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