{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2024,8,6]],"date-time":"2024-08-06T06:01:01Z","timestamp":1722924061939},"reference-count":17,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2014,7,3]],"date-time":"2014-07-03T00:00:00Z","timestamp":1404345600000},"content-version":"vor","delay-in-days":2,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Thoracic Cancer"],"published-print":{"date-parts":[[2014,7]]},"abstract":"Abstract<\/jats:title>Background<\/jats:title>The aim of this study was to confirm the association between the response to docetaxel combined with platinum as first\u2010line chemotherapy and prognosis and subsequent treatment for patients with non\u2010small cell lung cancer (NSCLC<\/jats:styled-content>).<\/jats:p><\/jats:sec>Methods<\/jats:title>This study enrolled 224 patients with NSCLC<\/jats:styled-content> diagnosed at our institution between J<\/jats:styled-content>anuary 2001 and A<\/jats:styled-content>ugust 2012. All patients received more than two cycles of docetaxel combined with platinum as first\u2010line chemotherapy and were reassessed after two cycles. The association between the response to first\u2010line treatment and prognosis and subsequent treatment were statistically analyzed.<\/jats:p><\/jats:sec>Results<\/jats:title>Among the 224 patients, 70 (31.25%) achieved partial response (PR<\/jats:styled-content>), 90 (40.18%) stable disease (SD<\/jats:styled-content>), and 64 (28.57%) progressive disease (PD<\/jats:styled-content>). The overall survival (OS<\/jats:styled-content>) of NSCLC<\/jats:styled-content> patients with PR<\/jats:styled-content>, SD<\/jats:styled-content> and PR<\/jats:styled-content>+SD<\/jats:styled-content> was significantly longer than those with PD<\/jats:styled-content> (P<\/jats:italic> = 0.043; P<\/jats:italic> = 0.000; P<\/jats:italic> = 0.001). However, no significant difference was observed in OS<\/jats:styled-content> between patients with PR<\/jats:styled-content> and SD<\/jats:styled-content> (P<\/jats:italic> = 0.174). Cox regression analysis found treatment response was an independent prognostic factor (hazard ratio = 1.615, 95% confidence interval: 1.121\u20132.327). Two independent non\u2010parametric sample tests showed that patients with a good response to first\u2010line treatment had received further treatment cycles and treatment lines (P<\/jats:italic> = 0.000; P<\/jats:italic> = 0.000).<\/jats:p><\/jats:sec>Conclusions<\/jats:title>Our study demonstrated that the response to docetaxel in combination with platinum as a first\u2010line chemotherapy was an independent prognostic factor for patients with NSCLC<\/jats:styled-content>. In addition, patients with a good response to first\u2010line treatment had received further treatment cycles and treatment lines.<\/jats:p><\/jats:sec>","DOI":"10.1111\/1759-7714.12099","type":"journal-article","created":{"date-parts":[[2014,2,19]],"date-time":"2014-02-19T02:16:33Z","timestamp":1392776193000},"page":"337-342","update-policy":"http:\/\/dx.doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Response to first\u2010line chemotherapy of docetaxel combined with platinum predicting the prognosis and subsequent treatment of patients with non\u2010small cell lung cancer"],"prefix":"10.1111","volume":"5","author":[{"given":"Hongbing","family":"Liu","sequence":"first","affiliation":[{"name":"Department of Respiratory Medicine Jinling Hospital, Nanjing University School of Medicine Nanjing China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ying","family":"Wu","sequence":"additional","affiliation":[{"name":"Department of Respiratory Medicine Jinling Hospital, Nanjing University School of Medicine Nanjing China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zhaofeng","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Respiratory Medicine Jinling Hospital, Nanjing University School of Medicine Nanjing China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yong","family":"Song","sequence":"additional","affiliation":[{"name":"Department of Respiratory Medicine Jinling Hospital, Nanjing University School of Medicine Nanjing China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2014,7,3]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.3322\/caac.20138"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0025-6196(11)60735-0"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1002\/cncr.21869"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1634\/theoncologist.13-S1-5"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.semtcvs.2008.09.002"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa011954"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.JTO.0000268673.95119.c7"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0169-5002(02)00444-0"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2004.10.576"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2003.12.038"},{"key":"e_1_2_7_12_1","volume-title":"TNM Classification of Malignant Tumors (UICC International Union Against Cancer)","author":"Sobin LH","year":"2009"},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejca.2008.10.026"},{"key":"e_1_2_7_14_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2000.18.10.2095"},{"key":"e_1_2_7_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0959-8049(02)00529-4"},{"key":"e_1_2_7_16_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF02850042"},{"key":"e_1_2_7_17_1","doi-asserted-by":"publisher","DOI":"10.1093\/annonc\/mdl174"},{"key":"e_1_2_7_18_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2007.10.8134"}],"container-title":["Thoracic Cancer"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2F1759-7714.12099","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/1759-7714.12099","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,1]],"date-time":"2023-10-01T23:57:57Z","timestamp":1696204677000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/1759-7714.12099"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014,7]]},"references-count":17,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2014,7]]}},"alternative-id":["10.1111\/1759-7714.12099"],"URL":"https:\/\/doi.org\/10.1111\/1759-7714.12099","archive":["Portico"],"relation":{},"ISSN":["1759-7706","1759-7714"],"issn-type":[{"value":"1759-7706","type":"print"},{"value":"1759-7714","type":"electronic"}],"subject":[],"published":{"date-parts":[[2014,7]]},"assertion":[{"value":"2013-11-24","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2014-02-09","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2014-07-03","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}