{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,10]],"date-time":"2025-10-10T18:52:42Z","timestamp":1760122362033,"version":"3.40.4"},"reference-count":17,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2015,3,2]],"date-time":"2015-03-02T00:00:00Z","timestamp":1425254400000},"content-version":"vor","delay-in-days":1,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Thoracic Cancer"],"published-print":{"date-parts":[[2015,3]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>The standard of care for patients with small cell lung cancer (<jats:styled-content style=\"fixed-case\">SCLC<\/jats:styled-content>) is chemotherapy and radiotherapy, even for patients with limited disease. To define the role of surgical resection in patients with limited<jats:styled-content style=\"fixed-case\">SCLC<\/jats:styled-content>, we investigated the outcomes of patients diagnosed with limited\u2010stage disease (<jats:styled-content style=\"fixed-case\">LD<\/jats:styled-content>)<jats:styled-content style=\"fixed-case\">SCLC<\/jats:styled-content>.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>The records of 57<jats:styled-content style=\"fixed-case\">LD SCLC<\/jats:styled-content>patients who underwent surgical resection from<jats:styled-content style=\"fixed-case\">A<\/jats:styled-content>pril 1974 to<jats:styled-content style=\"fixed-case\">M<\/jats:styled-content>arch 2012 were retrospectively analyzed.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>There were six women and 51 men, with a median age of 63.5 years. The overall five\u2010year survival rate was 28.6% (median, 18.2 months). The p\u2010stage<jats:styled-content style=\"fixed-case\">II<\/jats:styled-content>and<jats:styled-content style=\"fixed-case\">III<\/jats:styled-content>patients had a significantly worse survival than the p\u2010stage<jats:styled-content style=\"fixed-case\">I<\/jats:styled-content>patients (13.4% vs. 43.4%,<jats:italic>P<\/jats:italic>= 0.0036). However, the c\u2010stage was not found to correlate with survival. Patients who underwent pneumonectomy had a significantly worse outcome than those who underwent other surgical procedures (0.0% vs. 32.0%,<jats:italic>P<\/jats:italic>= 0.0002). In a multivariate Cox proportional hazards analysis, p\u2010stage<jats:styled-content style=\"fixed-case\">II<\/jats:styled-content>or<jats:styled-content style=\"fixed-case\">III<\/jats:styled-content>(hazard ratio [HR] 3.040<jats:italic>P<\/jats:italic>= 0.0017) and pneumonectomy (HR 6.177,<jats:italic>P<\/jats:italic>= 0.00159) were significant independent predictors of an adverse survival outcome.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Surgical treatment can be considered in<jats:styled-content style=\"fixed-case\">SCLC<\/jats:styled-content>patients with pathologically proven N0 status, although pneumonectomy should be avoided.<\/jats:p><\/jats:sec>","DOI":"10.1111\/1759-7714.12154","type":"journal-article","created":{"date-parts":[[2014,7,23]],"date-time":"2014-07-23T08:03:50Z","timestamp":1406102630000},"page":"141-145","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Surgical results of resectable small cell lung cancer"],"prefix":"10.1111","volume":"6","author":[{"given":"Daigo","family":"Kawano","sequence":"first","affiliation":[{"name":"Department of Surgery and Science Graduate School of Medical Sciences Kyushu University Fukuoka Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tatsuro","family":"Okamoto","sequence":"additional","affiliation":[{"name":"Department of Surgery and Science Graduate School of Medical Sciences Kyushu University Fukuoka 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