{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,26]],"date-time":"2026-08-26T19:01:10Z","timestamp":1787770870520,"version":"build-2784847793"},"reference-count":35,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2015,7,2]],"date-time":"2015-07-02T00:00:00Z","timestamp":1435795200000},"content-version":"vor","delay-in-days":1,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Thoracic Cancer"],"published-print":{"date-parts":[[2015,7]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>The aim of this study was to investigate the clinical characteristics and outcomes of patients with primary malignant mediastinal non\u2010seminomatous germ cell tumor (<jats:styled-content style=\"fixed-case\">MMNSGCT<\/jats:styled-content>) by comparing the efficacies of different treatment modalities.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>The charts of 62 consecutive patients with <jats:styled-content style=\"fixed-case\">MMNSGCT<\/jats:styled-content> between 1990 and 2010 were reviewed. Analyses included <jats:styled-content style=\"fixed-case\">K<\/jats:styled-content>aplan\u2010<jats:styled-content style=\"fixed-case\">M<\/jats:styled-content>eier survival and Cox multivariate regression.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>There was sufficient data of 61 patients for inclusion in the study. The median age was 25 years. At diagnosis, 35 patients had tumors located in the mediastinum, 26 had lung and\/or distant metastases. At a median follow\u2010up of 47.2 months, 32 patients had died and 43 had developed progressive disease. The one, three, and five\u2010year overall survival (<jats:styled-content style=\"fixed-case\">OS<\/jats:styled-content>) and progression\u2010free survival (<jats:styled-content style=\"fixed-case\">PFS<\/jats:styled-content>) rates were 72.1%, 50.8%, 49.2% and 47.5%, 32.8%, 32.8%, respectively. Patients who received radiotherapy in the primary treatment regimen showed improved five\u2010year <jats:styled-content style=\"fixed-case\">OS<\/jats:styled-content> (68.2% vs. 38.5%, <jats:italic>P<\/jats:italic>\u2009=\u2009<jats:italic>0.043<\/jats:italic>), <jats:styled-content style=\"fixed-case\">PFS<\/jats:styled-content> (45.5% vs. 20.5%, <jats:italic>P<\/jats:italic>\u2009=\u2009<jats:italic>0.023<\/jats:italic>), and local recurrence\u2010free survival (<jats:styled-content style=\"fixed-case\">LRFS<\/jats:styled-content>) (77.3% vs. 38.5%, <jats:italic>P<\/jats:italic>\u2009=\u2009<jats:italic>0.003<\/jats:italic>) compared with those who did not receive radiotherapy. Multivariate analysis revealed that radiotherapy was an independent prognostic factor of five\u2010year <jats:styled-content style=\"fixed-case\">OS<\/jats:styled-content> (hazard ratio [<jats:styled-content style=\"fixed-case\">HR]<\/jats:styled-content> 0.39, <jats:italic>P<\/jats:italic>\u2009=\u2009<jats:italic>0.037<\/jats:italic>), <jats:styled-content style=\"fixed-case\">PFS<\/jats:styled-content> (<jats:styled-content style=\"fixed-case\">HR<\/jats:styled-content> 0.42, <jats:italic>P<\/jats:italic>\u2009=\u2009<jats:italic>0.017<\/jats:italic>), and <jats:styled-content style=\"fixed-case\">LRFS<\/jats:styled-content> (<jats:styled-content style=\"fixed-case\">HR<\/jats:styled-content> 0.31, <jats:italic>P<\/jats:italic>\u2009=\u2009<jats:italic>0.019<\/jats:italic>).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Radiotherapy in a chemotherapy\u2010based treatment regimen could significantly reduce local recurrence and improve survival of <jats:styled-content style=\"fixed-case\">MMNGCT<\/jats:styled-content> patients.<\/jats:p><\/jats:sec>","DOI":"10.1111\/1759-7714.12190","type":"journal-article","created":{"date-parts":[[2014,10,15]],"date-time":"2014-10-15T06:53:39Z","timestamp":1413356019000},"page":"399-406","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":20,"title":["Role of radiotherapy in treating patients with primary malignant mediastinal non\u2010seminomatous germ cell tumor: A 21\u2010year experience at a single institution"],"prefix":"10.1111","volume":"6","author":[{"given":"Jianyang","family":"Wang","sequence":"first","affiliation":[{"name":"Cancer Hospital and Institute Chinese Academy of Medical Sciences and Peking Union Medical College Department of Radiation Oncology  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nan","family":"Bi","sequence":"additional","affiliation":[{"name":"Cancer Hospital and Institute 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