{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2024,8,31]],"date-time":"2024-08-31T15:42:10Z","timestamp":1725118930913},"reference-count":12,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2015,1,26]],"date-time":"2015-01-26T00:00:00Z","timestamp":1422230400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Thoracic Cancer"],"published-print":{"date-parts":[[2015,9]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Pulmonary metastasectomies are performed for a variety of cancers, though few reports have examined their merit for head and neck cancers. This study examined the relationship between clinical and pathological characteristics and survival after resection of lung metastases of these cancers.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Between 1986 and 2013, 34 patients presenting with pulmonary metastases of primary head or neck cancers underwent surgical resections at our institution. We retrospectively analyzed their clinical and pathological characteristics and the patients' survival after metastasectomy in search of adverse prognostic factors.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The primary sites of cancer were: the tongue in eight patients, the pharynx and salivary glands each in seven, the larynx in five, and miscellaneous sites in seven patients. Squamous cell carcinoma (<jats:styled-content style=\"fixed-case\">SCC<\/jats:styled-content>) was present in 19, adenoid cystic carcinomas in 10, and other diagnoses in five patients. The median disease\u2010free interval (<jats:styled-content style=\"fixed-case\">DFI<\/jats:styled-content>) between the initial surgery and the metastasectomies was 40 months. The overall five\u2010year survival rate was 57.9%, and median survival time was 77 months. By single variable analysis, a <jats:styled-content style=\"fixed-case\">DFI<\/jats:styled-content> of \u226426 months, age \u226560 years, and histology of <jats:styled-content style=\"fixed-case\">SCC<\/jats:styled-content> were predictors; by multiple variable analysis, a short <jats:styled-content style=\"fixed-case\">DFI<\/jats:styled-content> (<jats:italic>P<\/jats:italic> = 0.018) and older age (<jats:italic>P<\/jats:italic> = 0.046) remained independent predictors of poor clinical outcomes.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Young age and a long <jats:styled-content style=\"fixed-case\">DFI<\/jats:styled-content> are factors in favor of pulmonary metastasectomy after surgical treatment of primary head or neck cancers.<\/jats:p><\/jats:sec>","DOI":"10.1111\/1759-7714.12225","type":"journal-article","created":{"date-parts":[[2015,1,26]],"date-time":"2015-01-26T09:26:55Z","timestamp":1422264415000},"page":"579-583","update-policy":"http:\/\/dx.doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":19,"title":["Survival predictors after resection of lung metastases of head or neck cancers"],"prefix":"10.1111","volume":"6","author":[{"given":"Masaya","family":"Yotsukura","sequence":"first","affiliation":[{"name":"Division of General Thoracic Surgery Department of Surgery Keio University School of Medicine  Tokyo Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tomonari","family":"Kinoshita","sequence":"additional","affiliation":[{"name":"Division of General Thoracic Surgery Department of Surgery Keio University School of Medicine  Tokyo Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mitsutomo","family":"Kohno","sequence":"additional","affiliation":[{"name":"Division of General Thoracic Surgery Department of Surgery Keio University School of Medicine  Tokyo Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Keisuke","family":"Asakura","sequence":"additional","affiliation":[{"name":"Division of General Thoracic Surgery Department of Surgery Keio University School of Medicine  Tokyo Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ikuo","family":"Kamiyama","sequence":"additional","affiliation":[{"name":"Division of General Thoracic Surgery Department of Surgery Keio University School of Medicine  Tokyo Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Katsura","family":"Emoto","sequence":"additional","affiliation":[{"name":"Department of Pathology Keio University Hospital  Tokyo 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