{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,15]],"date-time":"2026-01-15T02:37:54Z","timestamp":1768444674739,"version":"3.49.0"},"reference-count":14,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2015,3,19]],"date-time":"2015-03-19T00:00:00Z","timestamp":1426723200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Thoracic Cancer"],"published-print":{"date-parts":[[2016,1]]},"abstract":"Abstract<\/jats:title>Primary pulmonary non\u2010H<\/jats:styled-content>odgkin's lymphoma (NHL<\/jats:styled-content>) is very rare. It represents less than 1% of all NHL<\/jats:styled-content>, and 0.5\u20131% of all primary pulmonary malignancies. Almost all cases of primary pulmonary NHL<\/jats:styled-content> originate from B<\/jats:styled-content>\u2010cell lineage. We present a case of a 53\u2010year\u2010old man with primary extranodal NK<\/jats:styled-content>\/T<\/jats:styled-content>\u2010cell lymphoma of the bronchus and lung, presented progressive dyspnea caused by right lower lung consolidation, and pleural effusion. Initial chest computed tomography suggested advanced lung cancer. Bronchofiberscopy showed a polypoid tumor on which a biopsy was performed. Histologically, the diffusely infiltrative atypical cells were positive for cytoplasmic CD<\/jats:styled-content>3, CD<\/jats:styled-content>56, granzyme B<\/jats:styled-content>, and negative for cytokeratin, CD<\/jats:styled-content>20 immunostains, suggesting NK<\/jats:styled-content>\/T<\/jats:styled-content> cell lineages. In situ<\/jats:italic> hybridization for E<\/jats:styled-content>pstein\u2010B<\/jats:styled-content>arr virus encoded ribonucleic acid (EBER<\/jats:styled-content>) was positive. Herein, we discuss the clinicopathological features of this case and review the literature on primary extranodal NK<\/jats:styled-content>\/T<\/jats:styled-content>\u2010cell lymphoma of the lung. Compared with other patients, who died after the first cycle of chemotherapy and\/or within three months, our patient had longer survival under aggressive chemotherapy and auto\u2010peripheral blood stem cell transplantation.<\/jats:p>","DOI":"10.1111\/1759-7714.12254","type":"journal-article","created":{"date-parts":[[2015,3,20]],"date-time":"2015-03-20T16:13:17Z","timestamp":1426867997000},"page":"140-144","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":18,"title":["Primary extranodal natural killer\/T<\/scp>\u2010cell lymphoma of bronchus and lung: A case report and review of literature"],"prefix":"10.1111","volume":"7","author":[{"given":"Chu\u2010Chun","family":"Chien","sequence":"first","affiliation":[{"name":"Department of Pathology and Laboratory Medicine Veterans General Hospital\u2010 Kaohsiung Kaohsiung Taiwan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Herng\u2010Sheng","family":"Lee","sequence":"additional","affiliation":[{"name":"Department of Pathology and Laboratory Medicine Veterans General Hospital\u2010 Kaohsiung Kaohsiung Taiwan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Min\u2010Hsi","family":"Lin","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, Chest Division Veterans General Hospital\u2010 Kaohsiung Kaohsiung Taiwan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Pin\u2010Pen","family":"Hsieh","sequence":"additional","affiliation":[{"name":"Department of Pathology and Laboratory Medicine Veterans General Hospital\u2010 Kaohsiung Kaohsiung Taiwan"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2015,3,19]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1183\/09031936.02.00404102"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1097\/00000478-200108000-00003"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2559.1990.tb01157.x"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1096-8652(199812)59:4<309::AID-AJH7>3.0.CO;2-B"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1183\/09031936.00123911"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.rti.0000179472.46877.28"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.1136\/thx.2004.025767"},{"key":"e_1_2_6_9_1","first-page":"988","article-title":"Primary pulmonary involvement of NK\/T cell lymphoma: Report of two cases with literature review","volume":"46","author":"Xiao 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