{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,10]],"date-time":"2026-10-10T02:09:34Z","timestamp":1791598174546,"version":"4.3.4"},"reference-count":17,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2015,8,20]],"date-time":"2015-08-20T00:00:00Z","timestamp":1440028800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Thoracic Cancer"],"published-print":{"date-parts":[[2016,5]]},"abstract":"Abstract<\/jats:title>A woman in her 60s was evaluated for anterior chest pain. Computed tomography (CT<\/jats:styled-content>) revealed a 50 mm mass with irregular contrast enhancement in the anterior mediastinum. \u03b1\u2010fetoprotein (AFP<\/jats:styled-content>) level was elevated to 1188\u2009ng\/mL. A germ cell tumor was diagnosed, mostly comprising of a yolk sac tumor (YST<\/jats:styled-content>). Two courses of chemotherapy with cisplatin (CDDP<\/jats:styled-content>) and etoposide (VP16<\/jats:styled-content>) were administered and surgical tumor resection was then performed. The final diagnosis was YST<\/jats:styled-content>. CDDP<\/jats:styled-content> and VP16<\/jats:styled-content> were continued postoperatively; however, because the AFP<\/jats:styled-content> level increased about six months after surgery, the chemotherapy regimen was altered to bleomycin and CPT<\/jats:styled-content>\u201011. As the AFP<\/jats:styled-content> again increased and a CT<\/jats:styled-content> scan revealed tumor re\u2010enlargement, recurrent YST<\/jats:styled-content> was diagnosed and radiotherapy was administered. The patient received a total of 60 Gy (2 Gy per fraction). The tumor started to shrink during radiotherapy and AFP<\/jats:styled-content> levels decreased. By one month post\u2010radiotherapy, AFP<\/jats:styled-content> levels had normalized and the tumor had disappeared. As of six years after radiotherapy, the patient remains alive without recurrence. Mediastinal YSTs<\/jats:styled-content> are rare, and treatment usually includes surgery and preoperative and postoperative chemotherapy with cisplatin\u2010based regimens. Successful treatment with radiotherapy has occasionally been reported. Our patient showed recurrence of a YST<\/jats:styled-content> after surgery and chemotherapy, but achieved long\u2010term survival after radiotherapy. Few patients with YST<\/jats:styled-content> have undergone radiotherapy, but this approach was successful in our patient. In cases of postoperative recurrent YST<\/jats:styled-content> resistant to chemotherapy, radiotherapy, together with salvage surgery, may offer a valuable option.<\/jats:p>","DOI":"10.1111\/1759-7714.12302","type":"journal-article","created":{"date-parts":[[2015,8,20]],"date-time":"2015-08-20T10:43:52Z","timestamp":1440067432000},"page":"358-362","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":9,"title":["Successful radiotherapy in postoperative recurrence of a primary mediastinal yolk sac tumor: A case report"],"prefix":"10.1111","volume":"7","author":[{"given":"Masakuni","family":"Sakaguchi","sequence":"first","affiliation":[{"name":"Department of Radiology Nihon University School of Medicine Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Toshiya","family":"Maebayashi","sequence":"additional","affiliation":[{"name":"Department of Radiology Nihon University School of Medicine Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Takuya","family":"Aizawa","sequence":"additional","affiliation":[{"name":"Department of Radiology Nihon University School of Medicine Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Naoya","family":"Ishibashi","sequence":"additional","affiliation":[{"name":"Department of Radiology Nihon University School of Medicine Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shoko","family":"Fukushima","sequence":"additional","affiliation":[{"name":"Department of Radiology Nihon University School of Medicine Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tsutomu","family":"Saito","sequence":"additional","affiliation":[{"name":"Sonodakai Radiation Oncology Clinic Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2015,8,20]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1002\/1097-0142(195911\/12)12:6<1092::AID-CNCR2820120606>3.0.CO;2-V"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1699-0463.1967.tb01290.x"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajog.2010.12.014"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-3468(96)90264-X"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00292-014-1900-8"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0003-4975(10)63500-X"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0003-4975(10)66116-4"},{"key":"e_1_2_6_9_1","doi-asserted-by":"crossref","first-page":"826","DOI":"10.1016\/S0022-5223(19)38688-X","article-title":"Mediastinal germ cell tumors in childhood. 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