{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,24]],"date-time":"2026-01-24T06:36:38Z","timestamp":1769236598846,"version":"3.49.0"},"reference-count":28,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2015,11,1]],"date-time":"2015-11-01T00:00:00Z","timestamp":1446336000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Thoracic Cancer"],"published-print":{"date-parts":[[2016,3]]},"abstract":"Abstract<\/jats:title>Background<\/jats:title>To investigate the efficacy, safety, and tolerability of weekly docetaxel treatment in advanced non\u2010small cell lung cancer (NSCLC<\/jats:styled-content>) patients in K<\/jats:styled-content>orea.<\/jats:p><\/jats:sec>Methods<\/jats:title>This prospective observational study included K<\/jats:styled-content>orean advanced NSCLC<\/jats:styled-content> patients with E<\/jats:styled-content>astern C<\/jats:styled-content>ooperative O<\/jats:styled-content>ncology G<\/jats:styled-content>roup performance status <2 who received weekly monotherapy of docetaxel at a dose determined by the physician. Efficacy measurements included tumor response rate, overall survival (OS<\/jats:styled-content>), progression\u2010free survival, and one\u2010year survival rate. Safety was analyzed through recorded incidences of adverse events (AEs<\/jats:styled-content>), serious adverse events (SAEs<\/jats:styled-content>), deaths, and other related safety parameters, along with their toxicity grades.<\/jats:p><\/jats:sec>Results:\u2002<\/jats:title>Of 274 patients analyzed, one patient achieved a complete response and 42 partial responses; thus, the overall response rate was 15.7%. The OS<\/jats:styled-content> rate at baseline and at one\u2010year follow\u2010up was 38.3% and 33.8%, respectively. AEs<\/jats:styled-content> were reported in 229 (83.6%) patients. The most frequently reported hematologic AE<\/jats:styled-content> of grade \u22653 was a decrease in neutrophils, with 6.6% of the patients developing neutropenia. In non\u2010hematologic AEs<\/jats:styled-content> of grade \u22653, the most common were infection with unknown absolute neutrophil count and death not associated with C<\/jats:styled-content>ommon T<\/jats:styled-content>erminology C<\/jats:styled-content>riteria for A<\/jats:styled-content>dverse E<\/jats:styled-content>vents (CTCAE<\/jats:styled-content>) (4.7% each). The most common SAE<\/jats:styled-content> reported was death, not associated with CTCAE<\/jats:styled-content> (7.3%).<\/jats:p><\/jats:sec>Conclusions<\/jats:title>In K<\/jats:styled-content>orean patients, the weekly regimen of docetaxel monotherapy was safe and efficacious against advanced NSCLC<\/jats:styled-content>.<\/jats:p><\/jats:sec>","DOI":"10.1111\/1759-7714.12315","type":"journal-article","created":{"date-parts":[[2015,11,2]],"date-time":"2015-11-02T02:54:40Z","timestamp":1446432880000},"page":"207-214","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Safety and efficacy of single\u2010agent docetaxel (T<\/scp>axotere) administered weekly in non\u2010small cell lung carcinoma patients in K<\/scp>orea: An observational study"],"prefix":"10.1111","volume":"7","author":[{"given":"Sun Min","family":"Lim","sequence":"first","affiliation":[{"name":"Division of Medical Oncology Department of Internal Medicine Yonsei Cancer Center Seoul Korea"},{"name":"Division of Medical Oncology Department of Internal Medicine CHA University Bundang Medical Center Seongnam Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Byeong Bae","family":"Park","sequence":"additional","affiliation":[{"name":"Hanyang University College of Medicine Division of Hematology\u2010Oncology Department of Internal Medicine Seoul Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Keun\u2010Chil","family":"Park","sequence":"additional","affiliation":[{"name":"Samsung Medical Center Department of Hematology\u2010Oncology Seoul Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hoon\u2010Kyo","family":"Kim","sequence":"additional","affiliation":[{"name":"St. Vincent Hospital Department of Oncology Gyeonggi\u2010do Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jong Seok","family":"Lee","sequence":"additional","affiliation":[{"name":"Seoul National University Bundang Hospital Gyeonggi\u2010do Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sung Hwa","family":"Bae","sequence":"additional","affiliation":[{"name":"Daegu Catholic University Hospital Daegu Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Seung\u2010Sei","family":"Lee","sequence":"additional","affiliation":[{"name":"Kangbuk Samsung Medical Center Seoul Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jin\u2010Hyoung","family":"Kang","sequence":"additional","affiliation":[{"name":"The Catholic University of Korea Seoul St. Mary's Hospital Seoul Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Se\u2010Hoon","family":"Park","sequence":"additional","affiliation":[{"name":"Samsung Medical Center Department of Hematology\u2010Oncology Seoul Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gyeong\u2010Won","family":"Lee","sequence":"additional","affiliation":[{"name":"Gyeongsang National University Hospital Gyeongsang National University School of Medicine Gyeongnam Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hyo\u2010Rac","family":"Lee","sequence":"additional","affiliation":[{"name":"NHIC Ilsan Hospital Gyeonggi\u2010do Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jae Hong","family":"Seo","sequence":"additional","affiliation":[{"name":"Korea University Guro Hospital Seoul Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yong Tae","family":"Kim","sequence":"additional","affiliation":[{"name":"NHIC Ilsan Hospital Gyeonggi\u2010do Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sung Hyun","family":"Yang","sequence":"additional","affiliation":[{"name":"Korea Cancer Center Hospital Seoul Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Joo\u2010Hang","family":"Kim","sequence":"additional","affiliation":[{"name":"Division of Medical Oncology Department of Internal Medicine Yonsei Cancer Center Seoul Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2015,11]]},"reference":[{"key":"e_1_2_7_2_1","unstructured":"International Agency for Research on Cancer.Lung cancer incidence and mortality worldwide in 2008. GLOBOCAN 2008 Fact Sheet2008. [Cited 24 Mar 2011.] Available from URL:http:\/\/globocan.iarc.fr\/factsheets\/cancers\/lung.asp."},{"key":"e_1_2_7_3_1","unstructured":"Amercian Cancer Society.Global cancer facts and figures. ACS;2015. [Cited 5 Aug 2015.] Available from URL:http:\/\/www.cancer.org\/research\/cancerfactsstatistics\/cancerfactsfigures2015\/."},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0025-6196(11)60735-0"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1513\/pats.200809-110LC"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMra035536"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2001.19.13.3210"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa011954"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2009.23.5622"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2000.18.12.2354"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2000.18.10.2095"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.1634\/theoncologist.9-5-538"},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.1378\/chest.129.4.1031"},{"key":"e_1_2_7_14_1","doi-asserted-by":"publisher","DOI":"10.1093\/annonc\/mdi018"},{"key":"e_1_2_7_15_1","doi-asserted-by":"publisher","DOI":"10.1093\/jjco\/hyi191"},{"key":"e_1_2_7_16_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2005.02.3739"},{"key":"e_1_2_7_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ctrv.2006.07.003"},{"key":"e_1_2_7_18_1","doi-asserted-by":"publisher","DOI":"10.1093\/annonc\/mdj115"},{"key":"e_1_2_7_19_1","doi-asserted-by":"publisher","DOI":"10.1093\/annonc\/mdh349"},{"key":"e_1_2_7_20_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.bjc.6602241"},{"key":"e_1_2_7_21_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2014.55.8627"},{"key":"e_1_2_7_22_1","doi-asserted-by":"publisher","DOI":"10.1634\/theoncologist.2013-0411"},{"key":"e_1_2_7_23_1","doi-asserted-by":"publisher","DOI":"10.1002\/cncr.24563"},{"key":"e_1_2_7_24_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.lungcan.2007.10.008"},{"key":"e_1_2_7_25_1","doi-asserted-by":"publisher","DOI":"10.1185\/03007995.2010.525489"},{"key":"e_1_2_7_26_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2008.17.1405"},{"key":"e_1_2_7_27_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0959-8049(97)10050-8"},{"key":"e_1_2_7_28_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejca.2010.02.022"},{"key":"e_1_2_7_29_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2006.06.1044"}],"container-title":["Thoracic Cancer"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2F1759-7714.12315","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/1759-7714.12315","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/1759-7714.12315","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/1759-7714.12315","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,29]],"date-time":"2023-09-29T11:15:16Z","timestamp":1695986116000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/1759-7714.12315"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015,11]]},"references-count":28,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2016,3]]}},"alternative-id":["10.1111\/1759-7714.12315"],"URL":"https:\/\/doi.org\/10.1111\/1759-7714.12315","archive":["Portico"],"relation":{},"ISSN":["1759-7706","1759-7714"],"issn-type":[{"value":"1759-7706","type":"print"},{"value":"1759-7714","type":"electronic"}],"subject":[],"published":{"date-parts":[[2015,11]]},"assertion":[{"value":"2015-06-16","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2015-08-20","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2015-11-01","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}