{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2023,10,2]],"date-time":"2023-10-02T07:15:59Z","timestamp":1696230959849},"reference-count":17,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2016,1,4]],"date-time":"2016-01-04T00:00:00Z","timestamp":1451865600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Thoracic Cancer"],"published-print":{"date-parts":[[2016,5]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>To evaluate the pattern of lymph node metastasis (<jats:styled-content style=\"fixed-case\">LNM<\/jats:styled-content>) according to primary tumor location in <jats:styled-content style=\"fixed-case\">T<\/jats:styled-content>1 and <jats:styled-content style=\"fixed-case\">T<\/jats:styled-content>2 stage non\u2010small cell lung cancer (<jats:styled-content style=\"fixed-case\">NSCLC<\/jats:styled-content>) patients.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>The data of 1916 <jats:styled-content style=\"fixed-case\">NSCLC<\/jats:styled-content> patients with <jats:styled-content style=\"fixed-case\">LNM<\/jats:styled-content> who underwent surgery with systematic nodal resection between <jats:styled-content style=\"fixed-case\">N<\/jats:styled-content>ovember 2008 to <jats:styled-content style=\"fixed-case\">D<\/jats:styled-content>ecember 2014 were included in the study. Analyses of tumor location, pathological <jats:styled-content style=\"fixed-case\">T<\/jats:styled-content> stage, and nodal metastasis were performed.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>In <jats:styled-content style=\"fixed-case\">T<\/jats:styled-content>1a stage patients, superior mediastinum, aortopulmonary, and inferior mediastinum lymph node metastases were observed in primary tumors present in the right upper lobe (<jats:styled-content style=\"fixed-case\">RUL<\/jats:styled-content>), left upper lobe (<jats:styled-content style=\"fixed-case\">LUL<\/jats:styled-content>) and right middle lobe (<jats:styled-content style=\"fixed-case\">RML<\/jats:styled-content>), respectively. In <jats:styled-content style=\"fixed-case\">T<\/jats:styled-content>1b\u2010stage patients, superior mediastinum, aortopulmonary, and inferior mediastinum lymph node metastases were observed in the <jats:styled-content style=\"fixed-case\">RML<\/jats:styled-content>, <jats:styled-content style=\"fixed-case\">LUL,<\/jats:styled-content> and right lower lobe (<jats:styled-content style=\"fixed-case\">RLL<\/jats:styled-content>), respectively. In patients with <jats:styled-content style=\"fixed-case\">T<\/jats:styled-content>2a\u2010stage, superior mediastinum, aortopulmonary and inferior mediastinum lymph node metastases were observed in the <jats:styled-content style=\"fixed-case\">RUL<\/jats:styled-content>, <jats:styled-content style=\"fixed-case\">LUL,<\/jats:styled-content> and <jats:styled-content style=\"fixed-case\">RLL,<\/jats:styled-content> respectively. However, in T2b\u2010stage patients, <jats:styled-content style=\"fixed-case\">RUL<\/jats:styled-content>, <jats:styled-content style=\"fixed-case\">LUL<\/jats:styled-content> and <jats:styled-content style=\"fixed-case\">RML<\/jats:styled-content> locations were associated with superior mediastinum, aortopulmonary, and inferior mediastinum lymph node metastases, respectively. Multivariable logistic regression showed that <jats:styled-content style=\"fixed-case\">T<\/jats:styled-content> stage was significantly associated with mediastinal and intrapulmonary lymph node metastases. In addition, tumor location was significantly associated with <jats:styled-content style=\"fixed-case\">N<\/jats:styled-content>2 station <jats:styled-content style=\"fixed-case\">LNM<\/jats:styled-content>.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p><jats:styled-content style=\"fixed-case\">LNM<\/jats:styled-content> varied according to tumor location and <jats:styled-content style=\"fixed-case\">T<\/jats:styled-content>\u2010stage, which are independent factors influencing <jats:styled-content style=\"fixed-case\">N<\/jats:styled-content>2 station <jats:styled-content style=\"fixed-case\">LNM<\/jats:styled-content>.<\/jats:p><\/jats:sec>","DOI":"10.1111\/1759-7714.12328","type":"journal-article","created":{"date-parts":[[2016,1,5]],"date-time":"2016-01-05T03:14:32Z","timestamp":1451963672000},"page":"304-309","update-policy":"http:\/\/dx.doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Lymph node metastasis according to primary tumor location in <scp>T<\/scp>1 and <scp>T<\/scp>2 stage non\u2010small cell lung cancer patients"],"prefix":"10.1111","volume":"7","author":[{"given":"Jian","family":"Xiong","sequence":"first","affiliation":[{"name":"Department of Thoracic Surgery Fudan University Shanghai Cancer Center  Shanghai China"},{"name":"Department of Oncology Shanghai Medical College Fudan University  Shanghai China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rui","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Thoracic Surgery Fudan University Shanghai Cancer Center  Shanghai China"},{"name":"Department of Oncology Shanghai Medical College Fudan University  Shanghai China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yihua","family":"Sun","sequence":"additional","affiliation":[{"name":"Department of Thoracic Surgery Fudan University Shanghai Cancer Center  Shanghai China"},{"name":"Department of Oncology Shanghai 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