{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,3]],"date-time":"2026-07-03T00:02:55Z","timestamp":1783036975420,"version":"3.54.6"},"reference-count":16,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2016,3,24]],"date-time":"2016-03-24T00:00:00Z","timestamp":1458777600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"DOI":"10.13039\/100007452","name":"Wu Jieping Medical Foundation","doi-asserted-by":"publisher","award":["320.6799.1136"],"award-info":[{"award-number":["320.6799.1136"]}],"id":[{"id":"10.13039\/100007452","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Thoracic Cancer"],"published-print":{"date-parts":[[2016,7]]},"abstract":"<jats:sec><jats:title>Background<\/jats:title><jats:p>Non\u2010small\u2010cell lung cancer (<jats:styled-content style=\"fixed-case\">NSCLC<\/jats:styled-content>) is the leading cause of death from cancer in China. Gefitinib is effective for patients with positive epidermal growth factor receptor gene mutation; however, acquired drug resistance counteracts the duration response. Hyperthermia is widely clinically applied in the treatment of solid tumors. This pilot study was designed to evaluate the feasibility of the combination of gefitinib and hyperthermia.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Patients newly diagnosed with advanced <jats:styled-content style=\"fixed-case\">NSCLC<\/jats:styled-content> were screened. Eleven patients who responded to first\u2010line gefitinib treatment were enrolled in the study. Along with 250 mg gefitinib daily, local radiofrequency hyperthermia was administered twice a week until tumor progression was observed. The serum, heat shock protein (<jats:styled-content style=\"fixed-case\">HSP<\/jats:styled-content>)70, was also frequently detected during the course.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The most common toxicity included skin rash (81.8%) and abnormal liver function (45.5%) when treated with gefitinib, and fatty scleroma (36.4%) was observed when combined with hyperthermia. Grade 3 side effects (skin rash) occurred in only one patient. Median progression\u2010free survival was 22 months (95% confidence interval [<jats:styled-content style=\"fixed-case\">CI]<\/jats:styled-content>: 12.95\u201331.05 months) and median overall survival was 26 months (95% <jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content>: 22.81\u201329.19 months). Serum <jats:styled-content style=\"fixed-case\">HSP70<\/jats:styled-content> concentration increased and maintained a significantly high level compared with the baseline before hyperthermia administration.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>The novel therapy of gefitinib combined with radiofrequency hyperthermia is safe and effective for advanced <jats:styled-content style=\"fixed-case\">NSCLC<\/jats:styled-content> patients. Whether an improvement in therapeutic efficacy is associated with the elevation of serum <jats:styled-content style=\"fixed-case\">HSP70<\/jats:styled-content> concentration requires further study.<\/jats:p><\/jats:sec>","DOI":"10.1111\/1759-7714.12346","type":"journal-article","created":{"date-parts":[[2016,3,24]],"date-time":"2016-03-24T09:10:12Z","timestamp":1458810612000},"page":"422-427","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["Pilot study of radiofrequency hyperthermia in combination with gefitinib in gefitinib\u2010effective patients with advanced <scp>NSCLC<\/scp>"],"prefix":"10.1111","volume":"7","author":[{"given":"Yijia","family":"Qin","sequence":"first","affiliation":[{"name":"West China School of Medicine Sichuan University  Chengdu China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yu","family":"Sun","sequence":"additional","affiliation":[{"name":"Department of Radiation Oncology West China Hospital, Sichuan University  Chengdu China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yongmei","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Thoracic Oncology West China Hospital, Sichuan University  Chengdu China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yiqiao","family":"Luo","sequence":"additional","affiliation":[{"name":"West China School of Medicine Sichuan University  Chengdu China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiang","family":"Zhu","sequence":"additional","affiliation":[{"name":"Department of Thoracic Oncology West China Hospital, Sichuan University  Chengdu China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2016,3,24]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa0909530"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1470-2045(02)00818-5"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10147-006-0647-5"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0163-7258(98)00028-X"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1186\/1471-2407-7-189"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejca.2008.10.026"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.1099314"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.3346\/jkms.2013.28.11.1595"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1158\/1078-0432.CCR-12-2246"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.3109\/02656739509022453"},{"key":"e_1_2_7_12_1","first-page":"151","article-title":"Clinical 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