{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,31]],"date-time":"2026-03-31T20:11:19Z","timestamp":1774987879718,"version":"3.50.1"},"reference-count":25,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2017,2,3]],"date-time":"2017-02-03T00:00:00Z","timestamp":1486080000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100007937","name":"Peking University","doi-asserted-by":"publisher","award":["2013\u20105\u201005"],"award-info":[{"award-number":["2013\u20105\u201005"]}],"id":[{"id":"10.13039\/501100007937","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Thoracic Cancer"],"published-print":{"date-parts":[[2017,3]]},"abstract":"<jats:sec><jats:title>Background<\/jats:title><jats:p>Visceral pleural invasion (<jats:styled-content style=\"fixed-case\">VPI<\/jats:styled-content>) is an adverse prognostic factor in non\u2010small cell lung cancer (<jats:styled-content style=\"fixed-case\">NSCLC<\/jats:styled-content>); however, its effect in relation to tumor size remains under debate. To better understand the prognostic impact and potential consequences for staging, we examined correlations between <jats:styled-content style=\"fixed-case\">VPI<\/jats:styled-content> and clinicopathologic characteristics in patients with <jats:styled-content style=\"fixed-case\">NSCLC<\/jats:styled-content>, particularly those with lymph node negative <jats:styled-content style=\"fixed-case\">NSCLC<\/jats:styled-content>.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We retrospectively analyzed 813 cases of radically resected <jats:styled-content style=\"fixed-case\">NSCLC<\/jats:styled-content> treated in our institution between <jats:styled-content style=\"fixed-case\">D<\/jats:styled-content>ecember 2005 and <jats:styled-content style=\"fixed-case\">D<\/jats:styled-content>ecember 2011. Patients were divided into two groups according to <jats:styled-content style=\"fixed-case\">VPI<\/jats:styled-content> status to compare their clinicopathologic characteristics. Survival analysis was performed in 521 cases with p<jats:styled-content style=\"fixed-case\">N<\/jats:styled-content>0 <jats:styled-content style=\"fixed-case\">NSCLC<\/jats:styled-content>.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>\n<jats:styled-content style=\"fixed-case\">VPI<\/jats:styled-content> was diagnosed in 379 (46.6%) cases. It was more common in women, patients with non\u2010squamous cell carcinoma, elevated preoperative serum carcinoembryonic antigen levels, moderately or poorly differentiated tumors, and larger\u2010sized tumors. The incidence of mediastinal lymph node metastasis, particularly multi\u2010station metastasis, was higher in patients with <jats:styled-content style=\"fixed-case\">VPI<\/jats:styled-content>. Patients with p<jats:styled-content style=\"fixed-case\">N<\/jats:styled-content>0 <jats:styled-content style=\"fixed-case\">NSCLC<\/jats:styled-content>, 2\u20133\u2009cm tumors, and <jats:styled-content style=\"fixed-case\">VPI<\/jats:styled-content> had a significantly poorer prognosis (<jats:styled-content style=\"fixed-case\">VPI<\/jats:styled-content> vs. non\u2010<jats:styled-content style=\"fixed-case\">VPI<\/jats:styled-content>: five\u2010year overall survival 78.3% vs. 84.5%, <jats:italic>P<\/jats:italic>\u2009=\u20090.039; five\u2010year disease\u2010free survival 69.2% vs. 80.0%, <jats:italic>P<\/jats:italic>\u2009=\u20090.046, respectively); however, no significant effect was observed for tumors \u22642, 3\u20135, and 5\u20137\u2009cm. <jats:styled-content style=\"fixed-case\">P<\/jats:styled-content>\u2010<jats:styled-content style=\"fixed-case\">N<\/jats:styled-content>0 patients with <jats:styled-content style=\"fixed-case\">VPI<\/jats:styled-content> had a significantly higher incidence of postoperative local recurrence and distant metastasis than those without <jats:styled-content style=\"fixed-case\">VPI<\/jats:styled-content> (<jats:italic>P<\/jats:italic>\u2009=\u20090.01), especially ipsilateral pleural recurrence.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>\n<jats:styled-content style=\"fixed-case\">VPI<\/jats:styled-content> was an adverse prognostic factor in radically resected p<jats:styled-content style=\"fixed-case\">N<\/jats:styled-content>0 <jats:styled-content style=\"fixed-case\">NSCLC<\/jats:styled-content>, especially for tumors 2\u20133\u2009cm in size.<\/jats:p><\/jats:sec>","DOI":"10.1111\/1759-7714.12412","type":"journal-article","created":{"date-parts":[[2017,2,3]],"date-time":"2017-02-03T13:24:30Z","timestamp":1486128270000},"page":"97-105","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":20,"title":["Effect of visceral pleural invasion on the prognosis of patients with lymph node negative non\u2010small cell lung cancer"],"prefix":"10.1111","volume":"8","author":[{"given":"Dan","family":"Tian","sequence":"first","affiliation":[{"name":"Department of Thoracic Surgery, Guangdong General Hospital Guangdong Academy of Medical Sciences  Guangzhou China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yuquan","family":"Pei","sequence":"additional","affiliation":[{"name":"Department of Thoracic Surgery II, Key Laboratory of Carcinogenesis and Translational Research (Ministry of Education) Peking University School of Oncology, Beijing Cancer Hospital and Institute  Beijing China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Qingfeng","family":"Zheng","sequence":"additional","affiliation":[{"name":"Department of Thoracic Surgery II, Key Laboratory of Carcinogenesis and Translational Research (Ministry of Education) Peking University School of Oncology, Beijing Cancer Hospital and Institute  Beijing China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jianzhi","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Thoracic Surgery II, Key Laboratory of Carcinogenesis and Translational Research (Ministry of Education) Peking University School of Oncology, Beijing Cancer Hospital and Institute  Beijing China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shaolei","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Thoracic Surgery II, Key Laboratory of Carcinogenesis and Translational Research (Ministry of Education) Peking University School of Oncology, Beijing Cancer Hospital and Institute  Beijing China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xing","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Thoracic Surgery II, Key Laboratory of Carcinogenesis and Translational Research (Ministry of Education) Peking University School of Oncology, Beijing Cancer Hospital and Institute  Beijing China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dongmei","family":"Lin","sequence":"additional","affiliation":[{"name":"Department of Pathology Peking University School of Oncology, Beijing Cancer Hospital and Institute  Beijing China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yue","family":"Yang","sequence":"additional","affiliation":[{"name":"Department of Thoracic Surgery II, Key Laboratory of Carcinogenesis and Translational Research (Ministry of Education) Peking University School of Oncology, Beijing Cancer Hospital and Institute  Beijing 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