{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,11]],"date-time":"2026-09-11T18:55:13Z","timestamp":1789152913102,"version":"build-2803163510"},"reference-count":17,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2017,2,21]],"date-time":"2017-02-21T00:00:00Z","timestamp":1487635200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Thoracic Cancer"],"published-print":{"date-parts":[[2017,5]]},"abstract":"Background<\/jats:title>Visceral pleural invasion (VPI<\/jats:styled-content>) is generally considered a poor prognostic factor in non\u2010small cell lung cancer (NSCLC<\/jats:styled-content>). VPI<\/jats:styled-content> is defined as penetration beyond the elastic layer of visceral pleura (PL<\/jats:styled-content>1), including the visceral pleural surface without the involvement of adjacent structures (PL<\/jats:styled-content>2) by cancer cells. The aim of this study was to evaluate the influence of the extent of VPI<\/jats:styled-content> on NSCLC<\/jats:styled-content> prognosis.<\/jats:p><\/jats:sec>Methods<\/jats:title>This was a retrospective study of 90 patients with resected node\u2010negative NSCLC<\/jats:styled-content> with VPI<\/jats:styled-content>. The overall survival (OS<\/jats:styled-content>) and disease\u2010free survival (DFS<\/jats:styled-content>) rates were estimated using the K<\/jats:styled-content>aplan\u2013M<\/jats:styled-content>eier m<\/jats:styled-content>ethod. Multivariate analysis for prognostic factors was performed using a C<\/jats:styled-content>ox proportional hazards regression model. The pattern of recurrence was also compared between PL<\/jats:styled-content>1 and PL<\/jats:styled-content>2 groups.<\/jats:p><\/jats:sec>Results<\/jats:title>Seventy\u2010three patients had PL<\/jats:styled-content>1. The three\u2010year OS<\/jats:styled-content> rates for the PL<\/jats:styled-content>1 and PL<\/jats:styled-content>2 groups were 97.4% and 82.4%, respectively (\nP<\/jats:italic>\n<\/jats:styled-content>\u2009=\u20090.004). The two\u2010year DFS<\/jats:styled-content> rates for PL<\/jats:styled-content>1 and PL<\/jats:styled-content>2 groups were 81.0% and 76.5%, respectively (\nP<\/jats:italic>\n<\/jats:styled-content>\u2009=\u20090.419). According to the multivariate analysis, PL<\/jats:styled-content>2 was not a significant prognostic factor for survival outcome in node\u2010negative NSCLC<\/jats:styled-content> with VPI<\/jats:styled-content> compared to PL<\/jats:styled-content>1 (hazard ratio for DFS<\/jats:styled-content> 1.753, 95% confidence interval 0.582\u20135.284; \nP<\/jats:italic>\n<\/jats:styled-content>\u2009=\u20090.319). In this study, six patients in the PL<\/jats:styled-content>1 and one in PL<\/jats:styled-content>2 group developed ipsilateral pleural recurrence (\nP<\/jats:italic>\n<\/jats:styled-content>\u2009=\u20091.000).<\/jats:p><\/jats:sec>Conclusion<\/jats:title>\nVPI<\/jats:styled-content> extent may not influence survival outcomes in patients with surgically resected node\u2010negative NSCLC<\/jats:styled-content> with VPI<\/jats:styled-content>.<\/jats:p><\/jats:sec>","DOI":"10.1111\/1759-7714.12424","type":"journal-article","created":{"date-parts":[[2017,2,21]],"date-time":"2017-02-21T16:38:35Z","timestamp":1487695115000},"page":"197-202","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":20,"title":["Extent of visceral pleural invasion and the prognosis of surgically resected node\u2010negative non\u2010small cell lung cancer"],"prefix":"10.1111","volume":"8","author":[{"given":"Yangki","family":"Seok","sequence":"first","affiliation":[{"name":"Department of Thoracic and Cardiovascular Surgery Kyungpook National University Medical Center Daegu South Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ji Yun","family":"Jeong","sequence":"additional","affiliation":[{"name":"Department of Pathology Kyungpook National University Medical Center Daegu South Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eungbae","family":"Lee","sequence":"additional","affiliation":[{"name":"Department of Thoracic and Cardiovascular Surgery Kyungpook National University Medical Center Daegu South Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2017,2,21]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1093\/ejcts\/ezs429"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1097\/JTO.0b013e31818e0d9f"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1378\/chest.11-2552"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.lungcan.2012.08.004"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1165\/rcmb.2005-0158OE"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0003-4975(00)02649-7"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jtcvs.2004.11.021"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1093\/ejcts\/ezu515"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1010-7940(03)00119-2"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12253-009-9201-x"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.1055\/s\u20100036\u20101586757"},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.1378\/chest.71.5.644"},{"key":"e_1_2_7_14_1","doi-asserted-by":"crossref","first-page":"1092","DOI":"10.1016\/S0022-5223(19)33983-2","article-title":"Prognostic significance of pleural lavage cytology immediately after thoracotomy in patients with lung cancer","volume":"106","author":"Kondo H","year":"1993","journal-title":"J Thorac Cardiovasc Surg"},{"key":"e_1_2_7_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0003-4975(02)04403-X"},{"key":"e_1_2_7_16_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00428-012-1317-9"},{"key":"e_1_2_7_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.athoracsur.2003.10.058"},{"key":"e_1_2_7_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jtcvs.2003.11.017"}],"container-title":["Thoracic 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