{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,18]],"date-time":"2026-03-18T12:39:39Z","timestamp":1773837579489,"version":"3.50.1"},"reference-count":19,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2017,4,25]],"date-time":"2017-04-25T00:00:00Z","timestamp":1493078400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"name":"Key Medical Research Subjects in Hebei Province","award":["2056"],"award-info":[{"award-number":["2056"]}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Thoracic Cancer"],"published-print":{"date-parts":[[2017,7]]},"abstract":"Background<\/jats:title>The study was conducted to examine esophageal and gastric cardia precursor progression.<\/jats:p><\/jats:sec>Methods<\/jats:title>After population\u2010based baseline screening, 145 precursor and 335 chronic inflammation cases were endoscopically surveyed for six\u2009years.<\/jats:p><\/jats:sec>Results<\/jats:title>Surveillance of interval and baseline diagnoses for 18 severe dysplasia (SD<\/jats:styled-content>) cases later detected were: 13, 23, 39, and 44\u2009months since a diagnosis of chronic inflammation in four cases; 6, 6, 6, 11, 13, 16, 16, and 23\u2009months since mild dysplasia (mD<\/jats:styled-content>) diagnoses in eight; and 6, 9, 10, 13, 18, and 48\u2009months since moderate dysplasia (MD<\/jats:styled-content>) diagnoses in six. Rates for 11 carcinoma in situ (C<\/jats:styled-content>is) cases later detected were: 7 and 18\u2009months since basal cell hyperplasia (B<\/jats:styled-content>ch) diagnoses in two; and 6, 6, 9, 13, 13, 18, 35, 44, and 50\u2009months since MD<\/jats:styled-content> diagnoses in nine. In 10 cancer cases later detected, rates were: 6, 6, 7, 18, 19, 34, 36, and 48\u2009months since SD<\/jats:styled-content> diagnoses in eight cases with submucosal carcinoma; 46\u2009months since MD<\/jats:styled-content> diagnosis in a T<\/jats:styled-content>\n2<\/jats:sub>\nN<\/jats:styled-content>\n0<\/jats:sub>\nM<\/jats:styled-content>\n0<\/jats:sub> carcinoma case; and 52\u2009months since B<\/jats:styled-content>ch diagnosis in another T<\/jats:styled-content>\n2<\/jats:sub>\nN<\/jats:styled-content>\n0<\/jats:sub>\nM<\/jats:styled-content>\n0<\/jats:sub> case.<\/jats:p><\/jats:sec>Conclusion<\/jats:title>Esophageal and gastric cardia precursors are heterogeneous. Male gender, advanced age, family history of upper gastrointestinal cancer, and multifocal dysplasia are significant independent predictors for progression, and B<\/jats:styled-content>ch\/mD<\/jats:styled-content>, MD<\/jats:styled-content>, and SD<\/jats:styled-content> constitute three distinctive entities regarding the risk of cancer.<\/jats:p><\/jats:sec>","DOI":"10.1111\/1759-7714.12446","type":"journal-article","created":{"date-parts":[[2017,4,25]],"date-time":"2017-04-25T16:55:37Z","timestamp":1493139337000},"page":"328-336","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Heterogeneity in esophageal and gastric cardia precursor progression during six\u2010year endoscopic surveillance after population\u2010based screening in a C<\/scp>hinese high\u2010risk region"],"prefix":"10.1111","volume":"8","author":[{"given":"Denggui","family":"Wen","sequence":"first","affiliation":[{"name":"Cancer Center Fourth Hospital of Hebei Medical University Shijiazhuang China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Liwei","family":"Zhang","sequence":"additional","affiliation":[{"name":"Cancer Center Fourth Hospital of Hebei Medical University Shijiazhuang China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiaoling","family":"Wang","sequence":"additional","affiliation":[{"name":"Cancer Center Fourth Hospital of Hebei Medical University Shijiazhuang China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiaoduo","family":"Wen","sequence":"additional","affiliation":[{"name":"Cancer Center Fourth Hospital of Hebei Medical University Shijiazhuang China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yi","family":"Yang","sequence":"additional","affiliation":[{"name":"Cancer Center Fourth Hospital of Hebei Medical University Shijiazhuang China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yuetong","family":"Chen","sequence":"additional","affiliation":[{"name":"Cancer Center Fourth Hospital of Hebei Medical University Shijiazhuang China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Guiying","family":"Wang","sequence":"additional","affiliation":[{"name":"Cancer Center Fourth Hospital of Hebei Medical University Shijiazhuang China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kohei","family":"Akazawa","sequence":"additional","affiliation":[{"name":"Medical Information, Affiliated Hospital Niigata University Niigata Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shijie","family":"Wang","sequence":"additional","affiliation":[{"name":"Cancer Center Fourth Hospital of Hebei Medical University Shijiazhuang China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Baoen","family":"Shan","sequence":"additional","affiliation":[{"name":"Cancer Center Fourth Hospital of Hebei Medical University Shijiazhuang China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2017,4,25]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.3322\/caac.21262"},{"key":"e_1_2_7_3_1","first-page":"47","volume-title":"Direction for the Screening and Early Treatment of Cancer in China","author":"Wang GQ","year":"2005"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.canep.2009.06.002"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1002\/1097-0142(19940415)73:8<2027::AID-CNCR2820730803>3.0.CO;2-3"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1523-5378.2010.00790.x"},{"issue":"1","key":"e_1_2_7_7_1","first-page":"159","article-title":"Intervention and follow\u2010up on human esophageal precancerous lesions in Henan, northern China, a high\u2010incidence area for esophageal cancer","volume":"29","author":"Wang LD","year":"2002","journal-title":"Gan To Kagaku Ryoho"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1079-2104(05)80226-4"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0714.2011.01054.x"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1097-0142(19960401)77:7<1244::AID-CNCR3>3.0.CO;2-I"},{"key":"e_1_2_7_11_1","first-page":"42","volume-title":"Pathology and Prevention of Esophageal Cancer","author":"Song SQ","year":"1994"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.1067\/mge.2001.116877"},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbcan.2005.07.003"},{"key":"e_1_2_7_14_1","doi-asserted-by":"publisher","DOI":"10.1093\/ije\/21.5.877"},{"key":"e_1_2_7_15_1","doi-asserted-by":"publisher","DOI":"10.1093\/ije\/26.6.1159"},{"key":"e_1_2_7_16_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10689-006-0004-x"},{"key":"e_1_2_7_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejmg.2009.07.003"},{"key":"e_1_2_7_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejmg.2010.06.011"},{"key":"e_1_2_7_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1383-5742(00)00019-3"},{"key":"e_1_2_7_20_1","doi-asserted-by":"publisher","DOI":"10.1002\/ijc.20616"}],"container-title":["Thoracic Cancer"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2F1759-7714.12446","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/1759-7714.12446","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,1]],"date-time":"2023-10-01T12:26:11Z","timestamp":1696163171000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/1759-7714.12446"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,4,25]]},"references-count":19,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2017,7]]}},"alternative-id":["10.1111\/1759-7714.12446"],"URL":"https:\/\/doi.org\/10.1111\/1759-7714.12446","archive":["Portico"],"relation":{},"ISSN":["1759-7706","1759-7714"],"issn-type":[{"value":"1759-7706","type":"print"},{"value":"1759-7714","type":"electronic"}],"subject":[],"published":{"date-parts":[[2017,4,25]]},"assertion":[{"value":"2017-01-22","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2017-03-19","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2017-04-25","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}