{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,2]],"date-time":"2026-08-02T16:15:05Z","timestamp":1785687305029,"version":"3.56.0"},"reference-count":21,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2017,7,31]],"date-time":"2017-07-31T00:00:00Z","timestamp":1501459200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81101610"],"award-info":[{"award-number":["81101610"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Thoracic Cancer"],"published-print":{"date-parts":[[2017,9]]},"abstract":"<jats:sec><jats:title>Background<\/jats:title><jats:p>Our objective was to investigate the efficacy and safety of oral prednisone for the prevention of esophageal stricture formation after endoscopic submucosal dissection (<jats:styled-content style=\"fixed-case\">ESD<\/jats:styled-content>) in an optimal administration program.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Patients who underwent circumferential or semi\u2010circumferential (more than three quarters but not a complete circular) <jats:styled-content style=\"fixed-case\">ESD<\/jats:styled-content> for esophageal squamous cell carcinoma were eligible for this study. Oral prednisolone was administered to the study group at a dose of 30\u2009mg\/day on the third day post\u2010<jats:styled-content style=\"fixed-case\">ESD<\/jats:styled-content>, and then tapered gradually (30, 25, 20, 15, 10, and 5\u2009mg for 14\u2009days). Serial esophagoscopy with iodine staining was performed to assess stenosis and tumor recurrence at one, three, six, and 12\u2009months after <jats:styled-content style=\"fixed-case\">ESD<\/jats:styled-content>. Endoscopic balloon dilatation was performed whenever patients experienced persistent dysphagia to solids. Data were statistically analyzed.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Twenty\u2010three patients (15 men, mean age 66.6\u2009years) were enrolled in the study. Post\u2010procedural esophageal stricture was significantly lower in the study group (23.1%) compared to the control (80%) (<jats:italic>P<\/jats:italic>\u2009&lt;\u20090.05). A significantly higher number of endoscopic balloon dilatation sessions were performed (<jats:italic>P<\/jats:italic>\u2009&lt;\u20090.05) in the control (13.5) than in the study group (0.69). There were no adverse events related to oral prednisolone or the procedure itself and no treatment\u2010related mortality was observed during the 12 month follow\u2010up.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Our study suggested an optimal administration program of oral prednisone therapy and demonstrated that it is safe and effective for the prevention of esophageal stricture in patients after complete or semi\u2010circular <jats:styled-content style=\"fixed-case\">ESD<\/jats:styled-content> for esophageal squamous cell carcinoma.<\/jats:p><\/jats:sec>","DOI":"10.1111\/1759-7714.12473","type":"journal-article","created":{"date-parts":[[2017,7,31]],"date-time":"2017-07-31T15:12:38Z","timestamp":1501513958000},"page":"489-494","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":42,"title":["Efficacy of prednisone for prevention of esophageal stricture after endoscopic submucosal dissection for superficial esophageal squamous cell carcinoma"],"prefix":"10.1111","volume":"8","author":[{"given":"Gaosu","family":"Zhou","sequence":"first","affiliation":[{"name":"Emergency Medicine Department The Military General Hospital of Beijing PLA  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fangfang","family":"Yuan","sequence":"additional","affiliation":[{"name":"Department of Intensive Care Unit General Hospital of Guangzhou Military Command  Guangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jizhen","family":"Cai","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Ophthalmogy, Zhongshan Ophthalmic Center Sun Yat\u2010Sen University  Guangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaowei","family":"Tang","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology, Guangdong Provincial Key Laboratory of Gastroenterology Nanfang Hospital, Southern Medical 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