{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2023,10,2]],"date-time":"2023-10-02T08:11:07Z","timestamp":1696234267741},"reference-count":19,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2017,8,3]],"date-time":"2017-08-03T00:00:00Z","timestamp":1501718400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Thoracic Cancer"],"published-print":{"date-parts":[[2017,11]]},"abstract":"<jats:sec><jats:title>Background<\/jats:title><jats:p>Chemoradiotherapy is the standard treatment for locally advanced non\u2010small cell lung cancer (<jats:styled-content style=\"fixed-case\">NSCLC<\/jats:styled-content>); however, it is disputed whether this treatment is suitable for patients aged \u226575. This study was conducted to determine the maximum tolerated dose (<jats:styled-content style=\"fixed-case\">MTD<\/jats:styled-content>) of pemetrexed for use in concurrent radiotherapy for elderly patients with locally advanced non\u2010squamous <jats:styled-content style=\"fixed-case\">NSCLC<\/jats:styled-content>.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>The eligibility criteria were as follows: aged \u226575 with inoperable stage <jats:styled-content style=\"fixed-case\">IIIA<\/jats:styled-content> or <jats:styled-content style=\"fixed-case\">IIIB<\/jats:styled-content> non\u2010squamous <jats:styled-content style=\"fixed-case\">NSCLC<\/jats:styled-content>, no history of chemotherapy or radiotherapy, a performance status of 0 or 1, and adequate organ function. The patients were scheduled to receive pemetrexed on days 1, 22, 43, and 64 with concurrent once daily thoracic radiotherapy (60\u2009Gy). The initial pemetrexed dose was 400 (level 1), and it was planned to increase the dose to 500\u2009mg\/m<jats:sup>2<\/jats:sup> (level 2).<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Two patients were enrolled in this trial. In the first case, the patient suffered prolonged leukocytopenia, and treatment was discontinued on day 35. In the second case, febrile neutropenia occurred on day 32, and the patient developed drug\u2010induced pneumonitis and acute respiratory distress syndrome. Both patients experienced dose\u2010limiting toxicities; therefore, the level 1 dose was considered to be the <jats:styled-content style=\"fixed-case\">MTD<\/jats:styled-content>.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>During combined treatment with pemetrexed and concurrent radiotherapy, a pemetrexed dose of 400\u2009mg\/m<jats:sup>2<\/jats:sup> was the <jats:styled-content style=\"fixed-case\">MTD<\/jats:styled-content>; we did not set up a phase <jats:styled-content style=\"fixed-case\">II<\/jats:styled-content> study. Concurrent chemoradiotherapy might be too toxic for elderly patients aged \u226575 with locally advanced <jats:styled-content style=\"fixed-case\">NSCLC<\/jats:styled-content>.<\/jats:p><\/jats:sec>","DOI":"10.1111\/1759-7714.12483","type":"journal-article","created":{"date-parts":[[2017,8,3]],"date-time":"2017-08-03T20:27:24Z","timestamp":1501792044000},"page":"577-581","update-policy":"http:\/\/dx.doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Phase <scp>I<\/scp> study of pemetrexed and concurrent radiotherapy for previously untreated elderly patients with locally advanced non\u2010squamous non\u2010small cell lung cancer"],"prefix":"10.1111","volume":"8","author":[{"given":"Shinnosuke","family":"Takemoto","sequence":"first","affiliation":[{"name":"Department of Respiratory Medicine Nagasaki University Graduate School of Biomedical Sciences  Nagasaki Japan"},{"name":"Department of Respiratory Medicine National Hospital Nagasaki Medical Center  Omura Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yoichi","family":"Nakamura","sequence":"additional","affiliation":[{"name":"Division of Thoracic Oncology, Department of Medical Oncology Tochigi Cancer Center  Tochigi Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Minoru","family":"Fukuda","sequence":"additional","affiliation":[{"name":"Department of Respiratory Medicine Nagasaki University Graduate School of Biomedical Sciences  Nagasaki Japan"},{"name":"Clinical Oncology Center Nagasaki University Hospital  Nagasaki Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hiroaki","family":"Senju","sequence":"additional","affiliation":[{"name":"Department of Respiratory Medicine Nagasaki University Graduate School of Biomedical Sciences  Nagasaki Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hiroshi","family":"Gyotoku","sequence":"additional","affiliation":[{"name":"Department of Respiratory Medicine Nagasaki University Graduate School of Biomedical Sciences  Nagasaki Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hirokazu","family":"Taniguchi","sequence":"additional","affiliation":[{"name":"Department of Respiratory Medicine Nagasaki University Graduate School of Biomedical Sciences  Nagasaki Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Midori","family":"Shimada","sequence":"additional","affiliation":[{"name":"Department of Respiratory Medicine Nagasaki University Graduate School of Biomedical Sciences  Nagasaki Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Takaya","family":"Ikeda","sequence":"additional","affiliation":[{"name":"Department of Respiratory Medicine Nagasaki University Graduate School of Biomedical Sciences  Nagasaki Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hiroyuki","family":"Yamaguchi","sequence":"additional","affiliation":[{"name":"Department of Respiratory Medicine Nagasaki University Graduate School of Biomedical Sciences  Nagasaki Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Katsumi","family":"Nakatomi","sequence":"additional","affiliation":[{"name":"Department of Respiratory Medicine Nagasaki University Graduate School of Biomedical Sciences  Nagasaki Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nobuyuki","family":"Hayashi","sequence":"additional","affiliation":[{"name":"Department of Radiotherapy Japanese Red Cross Nagasaki Genbaku Hospital  Nagasaki Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hiroshi","family":"Soda","sequence":"additional","affiliation":[{"name":"Department of Respiratory Medicine Sasebo City General Hospital  Sasebo Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hiroshi","family":"Mukae","sequence":"additional","affiliation":[{"name":"Department of Respiratory Medicine Nagasaki University Graduate School of Biomedical Sciences  Nagasaki Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2017,8,3]]},"reference":[{"key":"e_1_2_7_2_1","unstructured":"Ministry of Health Labour and Welfare.Current Population Survey. 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