{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,21]],"date-time":"2026-04-21T05:56:11Z","timestamp":1776750971898,"version":"3.51.2"},"reference-count":15,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2017,9,23]],"date-time":"2017-09-23T00:00:00Z","timestamp":1506124800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100008837","name":"Shanghai Chest Hospital","doi-asserted-by":"publisher","award":["YZ2015\u2010ZX14"],"award-info":[{"award-number":["YZ2015\u2010ZX14"]}],"id":[{"id":"10.13039\/501100008837","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Thoracic Cancer"],"published-print":{"date-parts":[[2017,11]]},"abstract":"Background<\/jats:title>The aim of this study was to investigate the patterns and influencing factors of local\u2010regional recurrence of lower thoracic esophageal squamous cell carcinoma (TESCC) after curative resection and to delineate the clinical target volume (CTV) of postoperative radiotherapy (PORT).<\/jats:p><\/jats:sec>Methods<\/jats:title>From January 2009 to December 2013, the clinical data of patients who experienced local\u2010regional recurrence after curative esophagectomy were collected and analyzed to determine local\u2010regional recurrence patterns and to evaluate whether a proposed T\u2010shaped PORT CTV could cover regions of local\u2010regional failure.<\/jats:p><\/jats:sec>Results<\/jats:title>A total of 108 patients were eligible for this study. All patients experienced postoperative recurrence of lower TESCC. The time to local\u2010regional failure varied from one to 52\u2009months (average 13.4\u2009\u00b1\u200911.0). Among the 108 patients, 127 recurrence sites were detected as the first recurrence event: 37 cases in the bilateral supraclavicular region, 56 in the upper mediastinum, 14 in the middle mediastinum, 15 in the upper abdominal lymph nodes, and five cases of anastomotic recurrence. The proposed PORT CTV could successfully cover 89 (82.4%) out of the 108 recurrences and 84.2% of the sites (107\/127) of recurrence in our sample.<\/jats:p><\/jats:sec>Conclusion<\/jats:title>Local\u2010regional recurrence of lower TESCC is mainly distributed in the supraclavicular, upper\u2010middle mediastinum, anastomotic stoma, and upper abdominal lymph node regions. The proposed T\u2010shaped PORT CTV field could cover over 80% of local\u2010regional failure in our sample; therefore, we suggest that PORT should focus on this area.<\/jats:p><\/jats:sec>","DOI":"10.1111\/1759-7714.12499","type":"journal-article","created":{"date-parts":[[2017,9,23]],"date-time":"2017-09-23T12:42:46Z","timestamp":1506170566000},"page":"630-633","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":16,"title":["Characteristics of the local recurrence pattern after curative resection and values in target region delineation in postoperative radiotherapy for lower thoracic esophageal squamous cell cancer"],"prefix":"10.1111","volume":"8","author":[{"given":"Jun","family":"Liu","sequence":"first","affiliation":[{"name":"Department of Radiation Oncology Shanghai Chest Hospital, Shanghai Jiaotong University Shanghai China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xuwei","family":"Cai","sequence":"additional","affiliation":[{"name":"Department of Radiation Oncology Shanghai Chest Hospital, Shanghai Jiaotong University Shanghai China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Qi","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Radiation Oncology Fudan University Shanghai Cancer Center Shanghai China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hongxuan","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Radiation Oncology Shanghai Chest Hospital, Shanghai Jiaotong University Shanghai China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yan","family":"Cheng","sequence":"additional","affiliation":[{"name":"Department of Radiation Oncology Shanghai Chest Hospital, Shanghai Jiaotong University Shanghai 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