{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,11]],"date-time":"2026-04-11T00:53:26Z","timestamp":1775868806378,"version":"3.50.1"},"reference-count":20,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2017,10,31]],"date-time":"2017-10-31T00:00:00Z","timestamp":1509408000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Thoracic Cancer"],"published-print":{"date-parts":[[2018,1]]},"abstract":"<jats:sec><jats:title>Background<\/jats:title><jats:p>Thymic complete resection is considered the standard treatment for all thymic tumors; however, the ideal resection for non\u2010myasthenic early stage thymic tumors has not yet been determined. We conducted a retrospective study to examine this unique scenario.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We retrospectively analyzed the data of 118 early stage thymoma patients who underwent thymectomy (<jats:styled-content style=\"fixed-case\">TM<\/jats:styled-content>) or thymomectomy (<jats:styled-content style=\"fixed-case\">TMM<\/jats:styled-content>) with curative intent between January 2003 and December 2013 at our institution. Patients with myasthenia, thymic carcinomas, tumors with undetermined histology, and more advanced stage thymoma patients were excluded. We compared overall survival (<jats:styled-content style=\"fixed-case\">OS<\/jats:styled-content>) and disease\u2010free survival (<jats:styled-content style=\"fixed-case\">DFS<\/jats:styled-content>) according to the extent of thymic resection, tumor staging, and size.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>One hundred and eighteen patients were staged as early thymoma.<jats:styled-content style=\"fixed-case\">TM<\/jats:styled-content>was performed in 43 (35.6%) patients and<jats:styled-content style=\"fixed-case\">TMM<\/jats:styled-content>in 75 (64.4%). Forty\u2010nine (65.3%) patients with a tumor \u2264 3\u2009cm underwent<jats:styled-content style=\"fixed-case\">TMM<\/jats:styled-content>, and 9 (20.9%)<jats:styled-content style=\"fixed-case\">TM<\/jats:styled-content>. Twenty\u2010six (34.7%) patients with a tumor &gt; 3\u2009cm underwent<jats:styled-content style=\"fixed-case\">TMM<\/jats:styled-content>, and 34 (79.1%)<jats:styled-content style=\"fixed-case\">TM<\/jats:styled-content>. Seventy\u2010four patients were categorized as stage<jats:styled-content style=\"fixed-case\">I<\/jats:styled-content>: 57 (76%) underwent<jats:styled-content style=\"fixed-case\">TMM<\/jats:styled-content>and 17 (39.5%)<jats:styled-content style=\"fixed-case\">TM<\/jats:styled-content>. Forty\u2010four patients were categorized as stage<jats:styled-content style=\"fixed-case\">II<\/jats:styled-content>: 18 (24%) underwent<jats:styled-content style=\"fixed-case\">TMM<\/jats:styled-content>and 26 (60.5%)<jats:styled-content style=\"fixed-case\">TM<\/jats:styled-content>. There was no statistically significant difference in recurrence between the groups (<jats:italic>P<\/jats:italic>=\u20090.250).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>No difference in the rate of recurrence was observed in early stage non\u2010myasthenic patients following thymic resection and<jats:styled-content style=\"fixed-case\">M<\/jats:styled-content>asaoka\u2013<jats:styled-content style=\"fixed-case\">K<\/jats:styled-content>oga staging. However, TM is considered a better option for early stage thymoma patients with tumors &gt; 3\u2009cm.<\/jats:p><\/jats:sec>","DOI":"10.1111\/1759-7714.12542","type":"journal-article","created":{"date-parts":[[2017,10,31]],"date-time":"2017-10-31T09:22:39Z","timestamp":1509441759000},"page":"88-93","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":16,"title":["Is thymomectomy sufficient for non\u2010myasthenic early stage thymoma patients? 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