{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,26]],"date-time":"2026-09-26T12:16:25Z","timestamp":1790424985890,"version":"4.1.0"},"reference-count":36,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2018,1,13]],"date-time":"2018-01-13T00:00:00Z","timestamp":1515801600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["510575"],"award-info":[{"award-number":["510575"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81372186"],"award-info":[{"award-number":["81372186"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81272218"],"award-info":[{"award-number":["81272218"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Thoracic Cancer"],"published-print":{"date-parts":[[2018,3]]},"abstract":"<jats:sec><jats:title>Background<\/jats:title><jats:p>Background: Bisphenol\u2009A (BPA) is an estrogen\u2010like chemical widely contained in daily supplies. There is evidence that environmental exposure to BPA could contribute to the development of hormone\u2010related cancers. As is reported in numerous studies, melatonin, an endogenous hormone secreted by the pineal gland, could markedly inhibit estrogen\u2010induced proliferation of breast cancer (BC) cells. In this study, we intended to reveal the effects of melatonin on BPA\u2010induced proliferation of estrogen receptor\u2010positive BC cells.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Methods: We used methyl thiazolyl tetrazolium, luciferase reporter gene and western blotting assays to testify the effect of melatonin on BPA\u2010mediated proliferation of MCF\u20107 and T47D cells.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Methyl thiazolyl tetrazolium and colony formation assays showed that melatonin could significantly abolish BPA\u2010elevated cell proliferation. Meanwhile, BPA\u2010upregulated phosphorylation of ERK and AKT was decreased by melatonin treatment. Mechanistically, we found that BPA was capable of upregulating the protein levels of steroid receptor coactivators (SRC\u20101, SRC\u20103), as well as promoting the estrogen response element activity. However, the addition of melatonin could remarkably block the elevation of steroid receptor coactivators expression and estrogen response element activity triggered by BPA.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Conclusions: Therefore, these results demonstrated that melatonin could abrogate BPA\u2010induced proliferation of BC cells. Therapeutically, melatonin could be regarded as a potential medication for BPA\u2010associated BC.<\/jats:p><\/jats:sec>","DOI":"10.1111\/1759-7714.12587","type":"journal-article","created":{"date-parts":[[2018,1,13]],"date-time":"2018-01-13T13:45:06Z","timestamp":1515851106000},"page":"368-375","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":36,"title":["Melatonin inhibits the proliferation of breast cancer cells induced by bisphenol A via targeting estrogen receptor\u2010related pathways"],"prefix":"10.1111","volume":"9","author":[{"given":"Tianjiao","family":"Wang","sequence":"first","affiliation":[{"name":"State Key Laboratory of Medicinal Chemical Biology, Department of Biochemistry, College of Life Sciences Nankai University  Tianjin China"},{"name":"Department of General Surgery, The Second Affiliated Hospital Institute of Cancer Stem Cell, Dalian Medical University Cancer Center  Dalian 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Laboratory of Medicinal Chemical Biology, Department of Biochemistry, College of Life Sciences Nankai University  Tianjin China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jinjin","family":"Pan","sequence":"additional","affiliation":[{"name":"Department of General Surgery, The Second Affiliated Hospital Institute of Cancer Stem Cell, Dalian Medical University Cancer Center  Dalian China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yanan","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of General Surgery, The Second Affiliated Hospital Institute of Cancer Stem Cell, Dalian Medical University Cancer Center  Dalian China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rui","family":"Liang","sequence":"additional","affiliation":[{"name":"Department of General Surgery, The Second Affiliated Hospital Institute of Cancer Stem Cell, Dalian Medical University Cancer Center  Dalian 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