{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,2,21]],"date-time":"2025-02-21T17:33:55Z","timestamp":1740159235258,"version":"3.37.3"},"reference-count":19,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2018,1,17]],"date-time":"2018-01-17T00:00:00Z","timestamp":1516147200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100004608","name":"Natural Science Foundation of Jiangsu Province","doi-asserted-by":"publisher","award":["BK20140736","BK20161386","BL2013026"],"award-info":[{"award-number":["BK20140736","BK20161386","BL2013026"]}],"id":[{"id":"10.13039\/501100004608","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81401903","81572273","81572937"],"award-info":[{"award-number":["81401903","81572273","81572937"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Thoracic Cancer"],"published-print":{"date-parts":[[2018,3]]},"abstract":"<jats:sec><jats:title>Background<\/jats:title><jats:p>Jiangsu Province, China, is highly developed economically and culturally, and has a high prevalence of lung cancer. We aimed to evaluate the diagnostic procedures, genetic aberration analysis status, and first\u2010line treatment models of lung cancer in Jiangsu Province.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Lung cancer patients diagnosed in 2016 at 22 tertiary care hospitals were evaluated. Demographic characteristics, tumor histology, staging, family history of lung cancer, auxiliary examinations, genetic testing, and first\u2010line treatment were collected on discharge. Diagnostic and treatment data were analyzed by descriptive statistics.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>A total of 928 patients were enrolled. Chest computed tomography was the most frequently used diagnostic method; pathology diagnosis was carried out by transbronchial lung biopsy and transthoracic needle aspiration. Stage\u2009T1\u20102N0M0 small\u2010cell lung cancer patients experienced surgical resection, and others received cisplatin and etoposide chemotherapy. Stage\u2009I and stage\u2009II non\u2010small cell lung cancer patients experienced surgical resection; stage\u2009III and stage\u2009IV patients received cisplatin and pemetrexed chemotherapy as first\u2010line treatment. Detection of epidermal growth factor receptor (<jats:italic>EGFR)<\/jats:italic> mutations occurred in 29.9% of non\u2010selective, 36.5% of locally advanced or metastatic, and 42.1% of advanced non\u2010squamous non\u2010small cell lung cancer. The overall <jats:italic>EGFR<\/jats:italic>\u2010positive rates were 49.0%, 52.5%, and 53.9%. A total 72.0% of patients with <jats:italic>EGFR<\/jats:italic> mutations were treated with tyrosine kinase inhibitors.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Chest computed tomography was the most commonly performed diagnostic method for lung cancer. First\u2010line treatment was primarily determined by disease stages and <jats:italic>EGFR<\/jats:italic> mutation status, with few expectations.<\/jats:p><\/jats:sec>","DOI":"10.1111\/1759-7714.12588","type":"journal-article","created":{"date-parts":[[2018,1,17]],"date-time":"2018-01-17T13:02:36Z","timestamp":1516194156000},"page":"376-383","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Multicenter study of diagnostic procedures, genetic aberration analysis, and first\u2010line treatment of lung cancer in Jiangsu Province, China"],"prefix":"10.1111","volume":"9","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0774-2379","authenticated-orcid":false,"given":"YangBo","family":"Hu","sequence":"first","affiliation":[{"name":"Department of Respiratory Medicine, Jinling Hospital Medical School of Southeast University  Nanjing 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