{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,22]],"date-time":"2026-10-22T13:42:26Z","timestamp":1792676546598,"version":"4.5.0"},"reference-count":32,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2018,5,14]],"date-time":"2018-05-14T00:00:00Z","timestamp":1526256000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100002456","name":"Chonnam National University","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100002456","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Thoracic Cancer"],"published-print":{"date-parts":[[2018,7]]},"abstract":"<jats:sec><jats:title>Background<\/jats:title><jats:p>In cases of EGFR\u2010tyrosine kinase inhibitor (TKI) failure, re\u2010biopsy may be useful to understand resistance mechanisms and guide further treatment decisions. However, performing re\u2010biopsy is challenging because of several hurdles. We assessed the feasibility of re\u2010biopsy in advanced non\u2010small cell lung cancer (NSCLC) patients in real\u2010world clinical practice.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We retrospectively reviewed the clinical and pathologic data of advanced NSCLC patients who experienced disease progression after previous treatment with EGFR\u2010TKIs at a single tertiary hospital in Korea between January 2014 and December 2016. Re\u2010biopsy specimens included small biopsy, surgical tissue, or liquid\u2010based cytology. <jats:italic>EGFR<\/jats:italic> mutation was tested using peptide nucleic acid\u2010mediated clamping PCR.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Of the 230 NSCLC patients that experienced progression after EGFR\u2010TKI therapy, 105 (45.7%) underwent re\u2010biopsy. Re\u2010biopsy was successfully performed in 94 (89.5%) patients, and 11 patients were diagnosed with no malignancy. The complication rate was 8.6%, including seven cases of pneumothorax. <jats:italic>EGFR<\/jats:italic> mutation testing was performed on 75 patients using re\u2010biopsy specimens. Of the 57 patients who had sensitizing mutations at diagnosis, T790M mutations were found in 19 (33.3%), while 38 (66.7%) had no T790M mutation. Multivariate analysis showed that the re\u2010biopsy group was younger (<jats:italic>P<\/jats:italic>\u2009=\u20090.002) and exhibited a previous response to EGFR\u2010TKIs (<jats:italic>P<\/jats:italic>\u2009&lt;\u20090.001).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Re\u2010biopsy in advanced NSCLC is feasible in real world clinical practice, particularly in younger patients and those who achieved a previous response to EGFR\u2010TKIs.<\/jats:p><\/jats:sec>","DOI":"10.1111\/1759-7714.12762","type":"journal-article","created":{"date-parts":[[2018,5,15]],"date-time":"2018-05-15T06:54:47Z","timestamp":1526367287000},"page":"856-864","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":22,"title":["Feasibility of re\u2010biopsy and <i>EGFR<\/i> mutation analysis in patients with non\u2010small cell lung cancer"],"prefix":"10.1111","volume":"9","author":[{"given":"Tae\u2010Ok","family":"Kim","sequence":"first","affiliation":[{"name":"Department of Internal Medicine Chonnam National University Medical School  Gwangju South Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4837-1321","authenticated-orcid":false,"given":"In\u2010Jae","family":"Oh","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine Chonnam National University Medical School  Gwangju South Korea"},{"name":"Lung and Esophageal Cancer Clinic Chonnam National University Hwasun Hospital  Jeonnam South Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bo Gun","family":"Kho","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine Chonnam National University Medical School  Gwangju South Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ha Young","family":"Park","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine Chonnam National University Medical School  Gwangju South Korea"},{"name":"Lung and Esophageal Cancer Clinic Chonnam National University Hwasun Hospital  Jeonnam South Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jin Sun","family":"Chang","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine Chonnam National University Medical School  Gwangju South Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cheol\u2010Kyu","family":"Park","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine Chonnam National University Medical School  Gwangju South Korea"},{"name":"Lung and Esophageal Cancer Clinic Chonnam National University Hwasun Hospital  Jeonnam South Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hong\u2010Joon","family":"Shin","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine Chonnam National University Medical School  Gwangju South Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jung\u2010Hwan","family":"Lim","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine Chonnam National University Medical School  Gwangju South Korea"},{"name":"Lung and Esophageal Cancer Clinic Chonnam National University Hwasun Hospital  Jeonnam South Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yong\u2010Soo","family":"Kwon","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine Chonnam National University Medical School  Gwangju South Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yu\u2010Il","family":"Kim","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine Chonnam National University Medical School  Gwangju South Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sung\u2010Chul","family":"Lim","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine Chonnam National University Medical School  Gwangju South Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Young\u2010Chul","family":"Kim","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine Chonnam National University Medical School  Gwangju South Korea"},{"name":"Lung and Esophageal Cancer Clinic Chonnam National University Hwasun Hospital  Jeonnam South Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yoo\u2010Duk","family":"Choi","sequence":"additional","affiliation":[{"name":"Lung and Esophageal Cancer Clinic Chonnam National University Hwasun Hospital  Jeonnam South Korea"},{"name":"Department of Pathology Chonnam National University Medical School  Gwangju South 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