{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,9]],"date-time":"2026-05-09T09:54:23Z","timestamp":1778320463912,"version":"3.51.4"},"reference-count":32,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2018,11,9]],"date-time":"2018-11-09T00:00:00Z","timestamp":1541721600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Thoracic Cancer"],"published-print":{"date-parts":[[2019,1]]},"abstract":"<jats:sec><jats:title>Background<\/jats:title><jats:p>Thymoma and thymic carcinoma are rare thymic epithelial tumors. We investigated the efficacy of first\u2010line gemcitabine and cisplatin (GP) chemotherapy versus gemcitabine and cisplatin chemotherapy combined with the anti\u2010angiogenic drug endostar (GP + E) in advanced thymoma and thymic carcinoma.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>The records of 45 patients with invasive metastatic thymomas or thymic carcinomas treated with GP as first\u2010line therapy between August 2008 and July 2017 at the Department of Respiratory Medicine, Peking University Cancer Hospital and Institute were retrospectively reviewed.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Eighteen patients (75%) in the GP + E group achieved a partial response and six (25%) had stable disease. In GP only group, nine (42.8%) patients achieved a partial response, 11 (52.4%) had stable disease, and one (4.8%) had progressive disease. The GP + E group had a significantly higher overall response rate (75% vs. 42.9%; <jats:italic>P<\/jats:italic> = 0.028), and median progression\u2010free survival (PFS) and overall survival (OS) of 19 and 76 months, respectively. In the GP only group, median PFS and OS were 16 and 29 months, respectively. PFS and OS were not significantly different between the groups.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>GP has moderate efficacy and could represent a suitable first\u2010line therapy for thymic carcinoma and thymoma. Chemotherapy combined with endostar could improve the overall response rate, but did not prolong PFS or OS.<\/jats:p><\/jats:sec>","DOI":"10.1111\/1759-7714.12891","type":"journal-article","created":{"date-parts":[[2018,11,9]],"date-time":"2018-11-09T11:30:12Z","timestamp":1541763012000},"page":"17-23","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":10,"title":["Efficacy and toxicities of gemcitabine and cisplatin combined with endostar in advanced thymoma and thymic carcinoma"],"prefix":"10.1111","volume":"10","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0379-3301","authenticated-orcid":false,"given":"Yang","family":"Wang","sequence":"first","affiliation":[{"name":"Department of Thoracic Oncology II Key Laboratory of Carcinogenesis and Translational Research (Ministry of Education\/Beijing), Peking University Cancer Hospital and Institute  Beijing China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jun","family":"Nie","sequence":"additional","affiliation":[{"name":"Department of Thoracic Oncology II Key Laboratory of Carcinogenesis and Translational Research (Ministry of Education\/Beijing), Peking University Cancer Hospital and Institute  Beijing China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ling","family":"Dai","sequence":"additional","affiliation":[{"name":"Department of Thoracic Oncology II Key Laboratory of Carcinogenesis and Translational Research (Ministry of Education\/Beijing), Peking University Cancer Hospital and Institute  Beijing China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Weiheng","family":"Hu","sequence":"additional","affiliation":[{"name":"Department of Thoracic Oncology II Key Laboratory of Carcinogenesis and Translational Research (Ministry of Education\/Beijing), Peking University Cancer Hospital and Institute  Beijing China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiaoling","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of Thoracic Oncology II Key Laboratory of Carcinogenesis and Translational Research (Ministry of Education\/Beijing), Peking University Cancer Hospital and Institute  Beijing China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jindi","family":"Han","sequence":"additional","affiliation":[{"name":"Department of Thoracic Oncology II Key Laboratory of Carcinogenesis and Translational Research (Ministry of Education\/Beijing), Peking University Cancer Hospital and Institute  Beijing China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiangjuan","family":"Ma","sequence":"additional","affiliation":[{"name":"Department of Thoracic Oncology II Key Laboratory of Carcinogenesis and Translational Research (Ministry of Education\/Beijing), Peking University Cancer Hospital and Institute  Beijing China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Guangming","family":"Tian","sequence":"additional","affiliation":[{"name":"Department of Thoracic Oncology II Key Laboratory of Carcinogenesis and Translational Research (Ministry of Education\/Beijing), Peking University Cancer Hospital and Institute  Beijing China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sen","family":"Han","sequence":"additional","affiliation":[{"name":"Department of Thoracic Oncology II Key Laboratory of Carcinogenesis and Translational Research (Ministry of Education\/Beijing), Peking University Cancer Hospital and Institute  Beijing China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jieran","family":"Long","sequence":"additional","affiliation":[{"name":"Department of Thoracic Oncology II Key Laboratory of Carcinogenesis and Translational Research (Ministry of Education\/Beijing), Peking University Cancer Hospital and Institute  Beijing China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ziran","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Thoracic Oncology II Key Laboratory of Carcinogenesis and Translational Research (Ministry of Education\/Beijing), Peking University Cancer Hospital and Institute  Beijing China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jian","family":"Fang","sequence":"additional","affiliation":[{"name":"Department of Thoracic Oncology II Peking University Cancer Hospital &amp; Institute  Beijing China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2018,11,9]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1097\/JTO.0b013e3181f1f62d"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejca.2012.02.047"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejca.2011.08.008"},{"key":"e_1_2_6_5_1","first-page":"146","volume-title":"Pathology & Genetics, Tumours of the Lung, Pleura, Thymus and Heart: World Health Organization Classification of Tumors","author":"M\u00fcller\u2010Hermelink HK","year":"2004"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejca.2007.11.004"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.1994.12.6.1164"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.1997.15.9.3093"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.7326\/0003-4819-129-2-199807150-00006"},{"key":"e_1_2_6_10_1","doi-asserted-by":"publisher","DOI":"10.1097\/JTO.0000000000000362"},{"key":"e_1_2_6_11_1","doi-asserted-by":"publisher","DOI":"10.2174\/1568011033353434"},{"key":"e_1_2_6_12_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa011954"},{"key":"e_1_2_6_13_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2005.07.757"},{"key":"e_1_2_6_14_1","doi-asserted-by":"publisher","DOI":"10.1023\/A:1026595525977"},{"key":"e_1_2_6_15_1","doi-asserted-by":"publisher","DOI":"10.1158\/1538-7445.AM2016-2890"},{"key":"e_1_2_6_16_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00432-012-1167-5"},{"key":"e_1_2_6_17_1","doi-asserted-by":"publisher","DOI":"10.1111\/1759-7714.12626"},{"key":"e_1_2_6_18_1","doi-asserted-by":"publisher","DOI":"10.1002\/1097-0142(19910701)68:1<30::AID-CNCR2820680106>3.0.CO;2-4"},{"key":"e_1_2_6_19_1","doi-asserted-by":"publisher","DOI":"10.1097\/00000421-200206000-00012"},{"key":"e_1_2_6_20_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.bjc.6690773"},{"key":"e_1_2_6_21_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00432-014-1800-6"},{"key":"e_1_2_6_22_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.1996.14.3.814"},{"key":"e_1_2_6_23_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2010.32.9607"},{"key":"e_1_2_6_24_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2009.25.9663"},{"key":"e_1_2_6_25_1","doi-asserted-by":"publisher","DOI":"10.2217\/fon.14.144"},{"key":"e_1_2_6_26_1","doi-asserted-by":"publisher","DOI":"10.1111\/1759-7714.12300"},{"key":"e_1_2_6_27_1","doi-asserted-by":"publisher","DOI":"10.1227\/01.NEU.0000097554.14112.55"},{"key":"e_1_2_6_28_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jtho.2015.09.007"},{"key":"e_1_2_6_29_1","doi-asserted-by":"publisher","DOI":"10.1093\/annonc\/mdu541"},{"key":"e_1_2_6_30_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbrc.2007.06.155"},{"key":"e_1_2_6_31_1","doi-asserted-by":"publisher","DOI":"10.1097\/MD.0000000000004183"},{"key":"e_1_2_6_32_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.aanat.2007.05.003"},{"key":"e_1_2_6_33_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1470-2045(14)71181-7"}],"container-title":["Thoracic Cancer"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2F1759-7714.12891","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/1759-7714.12891","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,15]],"date-time":"2023-09-15T07:47:56Z","timestamp":1694764076000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/1759-7714.12891"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,11,9]]},"references-count":32,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2019,1]]}},"alternative-id":["10.1111\/1759-7714.12891"],"URL":"https:\/\/doi.org\/10.1111\/1759-7714.12891","archive":["Portico"],"relation":{},"ISSN":["1759-7706","1759-7714"],"issn-type":[{"value":"1759-7706","type":"print"},{"value":"1759-7714","type":"electronic"}],"subject":[],"published":{"date-parts":[[2018,11,9]]},"assertion":[{"value":"2018-07-01","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2018-09-16","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2018-11-09","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}