{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,4]],"date-time":"2025-10-04T12:07:52Z","timestamp":1759579672971,"version":"3.40.5"},"reference-count":23,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2018,10,29]],"date-time":"2018-10-29T00:00:00Z","timestamp":1540771200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Thoracic Cancer"],"published-print":{"date-parts":[[2019,1]]},"abstract":"<jats:sec><jats:title>Background<\/jats:title><jats:p>The Ki\u201067 labeling index (LI) is a well\u2010known prognostic factor for primary breast cancer, but its clinical significance for metachronous axillary lymph node (ALN) recurrence has not been well documented.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Ki\u201067 expression in primary tumors (PTs) and ALN metastases (ALNMs) was evaluated in 21 patients and quantified to investigate the relationship between Ki\u201067 LIs in PTs and metachronous ALNMs.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The median Ki\u201067 LIs in the PTs and ALNMs were 25.2% (range: 2.3\u201380.2%) and 70% (range: 10.4\u201397.4%), respectively. A majority of patients had higher Ki\u201067 LIs in ALNMs than in PTs (76.2%, 16\/21). Disease\u2010specific survival was significantly better in patients with a lower\u2010than\u2010median ALNM Ki\u201067 LI (<jats:italic>P<\/jats:italic>\u2009=\u20090.019, log\u2010rank test). Receiver operating characteristic curves showed a PT Ki\u201067 LI of 62.8% as the optimal cutoff value and an ALNM Ki\u201067 LI of 65.1%. Accordingly, we divided the patients into four groups: PT Ki\u201067 LI lower than 62.8%\/ALNM Ki\u201067 LI lower than 65.1%, PT Ki\u201067 LI lower\/ALNM Ki\u201067 LI higher, PT Ki\u201067 LI higher\/ALNM Ki\u201067 LI higher, and PT Ki\u201067 LI higher\/ALNM Ki\u201067 LI lower. Disease\u2010specific survival was significantly better in patients with Ki\u201067 LI lower\/ALNM Ki\u201067 LI lower than in the other groups.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>This is the first study to show that the Ki\u201067 LI in metachronous ALNM is a prognostic factor for patients with metachronous ALN recurrence of breast cancer.<\/jats:p><\/jats:sec>","DOI":"10.1111\/1759-7714.12907","type":"journal-article","created":{"date-parts":[[2018,10,30]],"date-time":"2018-10-30T02:27:44Z","timestamp":1540866464000},"page":"96-102","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Changes in the Ki\u201067 labeling index between primary breast cancer and metachronous metastatic axillary lymph node: A retrospective observational study"],"prefix":"10.1111","volume":"10","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1359-8588","authenticated-orcid":false,"given":"Naoya","family":"Ishibashi","sequence":"first","affiliation":[{"name":"Department of Radiology Nihon University School of Medicine  Tokyo Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Haruna","family":"Nishimaki","sequence":"additional","affiliation":[{"name":"Department of Pathology Nihon University School of Medicine  Tokyo Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Toshiya","family":"Maebayashi","sequence":"additional","affiliation":[{"name":"Department of Radiology Nihon University School of Medicine  Tokyo Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Masaharu","family":"Hata","sequence":"additional","affiliation":[{"name":"Department of Radiation Oncology Yokohama City University Graduate School of Medicine  Kanagawa Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Keita","family":"Adachi","sequence":"additional","affiliation":[{"name":"Division of Breast and Endocrine Surgery, Department of Surgery Nihon University School of Medicine  Tokyo Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kenichi","family":"Sakurai","sequence":"additional","affiliation":[{"name":"Division of Breast and Endocrine Surgery, Department of Surgery Nihon University School of Medicine  Tokyo Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shinobu","family":"Masuda","sequence":"additional","affiliation":[{"name":"Department of Pathology Nihon University School of Medicine  Tokyo Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Masahiro","family":"Okada","sequence":"additional","affiliation":[{"name":"Department of Radiology Nihon University School of Medicine  Tokyo 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